Cholesterol 7-alpha-Hydroxylase

Publication Title: 
Molecular Endocrinology (Baltimore, Md.)

Ayurveda, the ancient Indian system of health care and medicine, has a well-organized materia medica in which plants form a dominant part. A key illustration of the exploitation of this knowledge toward the development of a modern drug is the isolation and characterization of two antihyperlipidemic compounds, Z-, and E-guggulsterone from the tree Commiphora mukul, the exudate of which has been traditionally used for mitigating lipid disorders.

Wu, Jun
Xia, Chunsheng
Meier, Jannika
Li, Suzhen
Hu, Xiao
Lala, Deepak S.
Publication Title: 
Journal of Lipid Research

Z-Guggulsterone is a major ingredient in the Indian traditional hypolipidemic remedy guggul. A study in mice has established that its hypolipidemic effect involves the farnesoid X receptor (FXR), presumably by acting as an antagonist of this receptor. It is generally assumed that the antagonism leads to induction of cytochrome P450 7A1 (CYP7A1), the rate-limiting enzyme converting free cholesterol to bile acids. In this study, we tested whether Z-guggulsterone indeed induces human CYP7A1.

Yang, Dongfang
Yang, Jian
Shi, Deshi
Xiao, Da
Chen, Yi-Tzai
Black, Chris
Deng, Ruitang
Yan, Bingfang
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To investigate the effects of Fufang Jiangzhi No. 3, a compound traditional Chinese herbal medicine, on cholesterol-bile acid metabolism in rabbits with hypercholesterolemia and to explore the mechanism. METHODS: Twenty-four male New Zealand white rabbits were randomly assigned into normal control group, untreated group and Fufang Jiangzhi No. 3 group, with 8 rabbits in each group. Rabbits in the untreated group and Fufang Jiangzhi No. 3 group were fed high cholesterol diet to induce hypercholesterolemia.

Mao, Qi-qi
Sun, Xu
Qiu, Dong-ni
Fu, Xiao-dong
Liu, Yi
Wang, Wen-jian
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