Cholesterol 7-alpha-Hydroxylase

Publication Title: 
Molecular Endocrinology (Baltimore, Md.)

Ayurveda, the ancient Indian system of health care and medicine, has a well-organized materia medica in which plants form a dominant part. A key illustration of the exploitation of this knowledge toward the development of a modern drug is the isolation and characterization of two antihyperlipidemic compounds, Z-, and E-guggulsterone from the tree Commiphora mukul, the exudate of which has been traditionally used for mitigating lipid disorders.

Author(s): 
Wu, Jun
Xia, Chunsheng
Meier, Jannika
Li, Suzhen
Hu, Xiao
Lala, Deepak S.
Publication Title: 
Journal of Lipid Research

Z-Guggulsterone is a major ingredient in the Indian traditional hypolipidemic remedy guggul. A study in mice has established that its hypolipidemic effect involves the farnesoid X receptor (FXR), presumably by acting as an antagonist of this receptor. It is generally assumed that the antagonism leads to induction of cytochrome P450 7A1 (CYP7A1), the rate-limiting enzyme converting free cholesterol to bile acids. In this study, we tested whether Z-guggulsterone indeed induces human CYP7A1.

Author(s): 
Yang, Dongfang
Yang, Jian
Shi, Deshi
Xiao, Da
Chen, Yi-Tzai
Black, Chris
Deng, Ruitang
Yan, Bingfang
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To investigate the effects of Fufang Jiangzhi No. 3, a compound traditional Chinese herbal medicine, on cholesterol-bile acid metabolism in rabbits with hypercholesterolemia and to explore the mechanism. METHODS: Twenty-four male New Zealand white rabbits were randomly assigned into normal control group, untreated group and Fufang Jiangzhi No. 3 group, with 8 rabbits in each group. Rabbits in the untreated group and Fufang Jiangzhi No. 3 group were fed high cholesterol diet to induce hypercholesterolemia.

Author(s): 
Mao, Qi-qi
Sun, Xu
Qiu, Dong-ni
Fu, Xiao-dong
Liu, Yi
Wang, Wen-jian
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