Publication Title: 
Current Opinion in Investigational Drugs (London, England: 2000)

SIRT1 (sirtuin 1) is the human ortholog of the yeast Sir2 (silent information regulator 2) protein, which is implicated in lifespan extension in model organisms, such as yeast, worms and flies. It is an NAD+-dependent protein deacetylase with over two dozen known substrates that affect a wide variety of cellular processes, ranging from metabolism, cell cycle, growth and differentiation, inflammation, senescence, apoptosis, stress response and aging.

Ghosh, Hiyaa Singhee
Publication Title: 
Human Molecular Genetics

Niemann-Pick type C (NPC) disease, an autosomal recessive disorder caused primarily by loss-of-function mutations in NPC1 gene, is characterized neuropathologically by intracellular cholesterol accumulation, gliosis and neuronal loss in selected brain regions. Recent studies have shown that NPC disease exhibits intriguing parallels with Alzheimer's disease (AD), including the presence of tau-positive neurofibrillary tangles (NFTs) and ?-amyloid (A?)-related peptides in vulnerable brain regions. Since enhanced cholesterol level, which acts as a risk factor for AD, can increase A?

Maulik, Mahua
Ghoshal, Bibaswan
Kim, John
Wang, Yanlin
Yang, Jing
Westaway, David
Kar, Satyabrata
Publication Title: 
Aging Cell

Biomarkers of aging are essential to predict mortality and aging-related diseases. Paradoxically, age itself imposes a limitation on the use of known biomarkers of aging because their associations with mortality generally diminish with age. How this pattern arises is, however, not understood. With meta-analysis we show that human leucocyte telomere length (TL) predicts mortality, and that this mortality association diminishes with age, as found for other biomarkers of aging.

Boonekamp, Jelle J.
Simons, Mirre J. P.
Hemerik, Lia
Verhulst, Simon
Publication Title: 
Psychiatric Research Reports
Shock, N. W.
Publication Title: 
Journal of the American Geriatrics Society
Berman, B. H.
Leon, D. F.
Publication Title: 
Dental Clinics of North America

In the late 1960's, preventive health care began to gain in popularity in the United States and the movement carried over into the 1970's. During this time, sizable decreases in deaths from heart disease, strokes, and accidents have been noted. As a result, the lowest death rate in the history of this country (8.9 per 1000) occurred in both 1975 and 1976. Since 1970, an increase in longevity has been documented and it can be said that Americans are living longer--not just longer but hopefully better!

Cooper, K. H.
Christen, A. G.
Publication Title: 
The Journal of Nutrition

A freeze-dried human diet, based on linoleic acid-enriched food stuffs derived from ruminants, was evaluated and compared with a similarly-prepared diet based on conventional ruminant-derived foodstuffs, using Porton rats in a whole-of-life study. A cereal-based stock diet was used for comparison. Serum biochemical and histopathological examinations were carried out at 0.25, 1.1 and 2.1 years of age and other rats were left until they died of natural causes.

Horn, P. L.
Laver, J. J.
Fogerty, A. C.
Johnson, A. R.
Publication Title: 
Kent, S.
Publication Title: 
Journal of Epidemiology and Community Health

An epidemiological study was carried out among a random sample of women aged 18 to 69 years to examine possible determinants of plasma high density lipoprotein and total cholesterol (HDL-C and T-C). In a multiple regression analysis consumption of alcohol, fatty fish, and parental longevity showed positive associations with HDL-C, which were statistically significant. Smoking habit, sucrose consumption, and a family history of ischaemic heart disease showed significantly negative associations.

Yarnell, J. W.
Milbank, J.
Walker, C. L.
Fehily, A. M.
Hayes, T. M.
Publication Title: 
Journal of Gerontology

Data were obtained from 70 individuals (M age = 78.7, SE = 4.1 years) who attended the Pritikin Longevity Center's 26-day residential program where they were exposed to a high-complex-carbohydrate, low-fat diet, and daily exercise. During the 26-day program, serum cholesterol was reduced from 222 (SE = 5) to 179 (SE = 5) mg/dl, and triglycerides were reduced from 156 (SE = 10) to 141 (SE = 7) mg/dl. Body weight was reduced an average of 2.2 kg. Treadmill performance increased from 3.7 (SE = .1) to 5.5 (SE = .2) METs.

Weber, F.
Barnard, R. J.
Roy, D.


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