Cholesterol

Publication Title: 
The Journal of the Association of Physicians of India

OBJECTIVES: Yoga based lifestyle modifications have been earlier shown to be beneficial in coronary artery disease in a small number of patients. We evaluated the role of lifestyle modification based on Yoga techniques, stress management and dietary modifications in retardation of coronary artery disease. METHODS: This prospective, controlled, open trial included angiographically proven coronary artery disease patients (71 patients in study group and 42 patients in control group).

Author(s): 
Yogendra, J.
Yogendra, Hansaji J.
Ambardekar, S.
Lele, R. D.
Shetty, S.
Dave, M.
Husein, Naaznin
Publication Title: 
Menopause (New York, N.Y.)

OBJECTIVE: Regular and continuous yoga exercise is one of the most important nonpharmacological methods of improving serum lipid concentrations, adipose tissue, and metabolic syndrome factors. The purpose of this study was to analyze the effects of yoga exercise on serum adiponectin and metabolic syndrome factors in obese postmenopausal Korean women. METHODS: Sixteen healthy postmenopausal women aged 54.50 ± 2.75 years with more than 36% body fat were randomly assigned to either a yoga exercise group (n = 8) or to a "no exercise" control group (n = 8).

Author(s): 
Lee, Jeong-Ah
Kim, Jong-Won
Kim, Do-Yeon
Publication Title: 
Clinical Chemistry

BACKGROUND: Lipid abnormalities contribute significantly to the increased risk of cardiovascular disease in diabetic and end-stage renal disease (ESRD) patients. Accumulating evidence supports a proatherogenic role for remnant lipoproteins. Thus, the aim of the present study was to compare remnant-like particle-cholesterol (RLP-C) in type 2 diabetic and ESRD patients with age- and gender-matched controls.

Author(s): 
Hirany, S.
O'Byrne, D.
Devaraj, S.
Jialal, I.
Publication Title: 
Circulation

BACKGROUND: Prospective studies indicate that baseline levels of C-reactive protein (CRP), the prototypic marker of inflammation, are associated with an increased risk for cardiovascular events. Limited studies have examined therapies that influence high-sensitive CRP (hs-CRP) levels, especially in hyperlipidemic patients.

Author(s): 
Jialal, I.
Stein, D.
Balis, D.
Grundy, S. M.
Adams-Huet, B.
Devaraj, S.
Publication Title: 
Arteriosclerosis, Thrombosis, and Vascular Biology

Clinical trials with statins have demonstrated significant reductions in cardiovascular events. Remnant lipoproteins are independent predictors of cardiovascular events. Because of the paucity of data on the effect of statins on remnant lipoproteins, we tested the effect of pravastatin, simvastatin, and atorvastatin on remnant lipoprotein cholesterol (RLP-C) levels in a randomized crossover study in patients with combined hyperlipidemia.

Author(s): 
Stein, D. T.
Devaraj, S.
Balis, D.
Adams-Huet, B.
Jialal, I.
Publication Title: 
Diabetes

We evaluated antihyperglycemic and anti-obese effects of Panax ginseng berry extract and its major constituent, ginsenoside Re, in obese diabetic C57BL/6J ob/ ob mice and their lean littermates. Animals received daily intraperitoneal injections of Panax ginseng berry extract for 12 days. On day 12, 150 mg/kg extract-treated ob/ob mice became normoglycemic (137 +/- 6.7 mg/dl) and had significantly improved glucose tolerance. The overall glucose excursion during the 2-h intraperitoneal glucose tolerance test decreased by 46% (P < 0.01) compared with vehicle-treated ob/ob mice.

Author(s): 
Attele, Anoja S.
Zhou, Yun-Ping
Xie, Jing-Tian
Wu, Ji An
Zhang, Liu
Dey, Lucy
Pugh, William
Rue, Paul A.
Polonsky, Kenneth S.
Yuan, Chun-Su
Publication Title: 
Arteriosclerosis, Thrombosis, and Vascular Biology

OBJECTIVE: Hypercholesterolemia is a major risk factor for coronary artery disease. Therapeutic lifestyle changes include dietary modifications such as inclusion of phytosterols, which effectively lowers low-density lipoprotein (LDL) cholesterol in margarines and other fats. Their effectiveness in nonfat moieties is not yet established. The aim of this study was to examine if phytosterols alter the plasma lipoprotein profile when incorporated into nonfat orange juice.

Author(s): 
Devaraj, Sridevi
Jialal, Ishwarlal
Vega-López, Sonia
Publication Title: 
The Journal of Nutrition

Soy intake reduces cholesterol levels. However, both the identity of the soy component or components that contribute to this reduction and the cellular mechanism producing this reduction are unknown. Soy consists of protein, lipids, fiber, and phytochemicals including isoflavones. We propose that the isoflavone component of soy mediates this effect, at least in part, by affecting cellular sterol homeostasis.

Author(s): 
Mullen, Eimear
Brown, Rachel M.
Osborne, Timothy F.
Shay, Neil F.
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

OBJECTIVES: It is now accepted that inhibition of cholesterol biosynthesis is effective in the primary and secondary prevention of heart disease. However, the perceived side-effects on muscle and liver reduce the general acceptance of statin drug therapy as well as compliance over the long term, which is necessary for prevention efforts to be successful. Chinese red yeast rice (CRYR) is a supplement containing lovastatin (monacolin K), eight other monacolins, pigments, tannins, and other phytochemicals.

Author(s): 
Li, Zhaoping
Seeram, Navindra P.
Lee, Rupo
Thames, Gail
Minutti, Chayo
Wang, He-Jing
Heber, David
Publication Title: 
Physiological Genomics

Intake of soy protein has been associated with improvements in lipid metabolism, with much attention being focused on the serum cholesterol-lowering property of soy. The component or components of soy that are responsible for improvements in lipid metabolism have been investigated and their specific actions debated. One component, the isoflavones, has been shown to have weak estrogenic activity, and recently, several research groups have suggested that isoflavones are activating peroxisome proliferator-activated receptors (PPARs).

Author(s): 
Mezei, Orsolya
Li, Yilan
Mullen, Eimear
Ross-Viola, Jennifer S.
Shay, Neil F.

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