Chromans

Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Cellular damage induced by free-radicals like Reactive Oxygen and Nitrogen Species (ROS and RNS) has been implicated in several disorders and diseases, including ageing. Hence naturally occurring anti-oxidant rich-herbs play a vital role in combating these conditions. The present study was carried out to investigate the in vitro free-radical quenching capacity of a known Ayurvedic poly-herbal formulation called Vayasthapana Rasayana.

Author(s): 
Mukherjee, Sourav
Pawar, Nayana
Kulkarni, Omkar
Nagarkar, Bhagyashri
Thopte, Shrikant
Bhujbal, Akshay
Pawar, Pankaj
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Cellular damage induced by free-radicals like Reactive Oxygen and Nitrogen Species (ROS and RNS) has been implicated in several disorders and diseases, including ageing. Hence naturally occurring anti-oxidant rich-herbs play a vital role in combating these conditions. The present study was carried out to investigate the in vitro free-radical quenching capacity of a known Ayurvedic poly-herbal formulation called Vayasthapana Rasayana.

Author(s): 
Mukherjee, Sourav
Pawar, Nayana
Kulkarni, Omkar
Nagarkar, Bhagyashri
Thopte, Shrikant
Bhujbal, Akshay
Pawar, Pankaj
Publication Title: 
Journal of Lipid Research

The metabolism of vitamin E involves oxidation of the phytyl chain to generate the terminal metabolite 7,8-dimethyl-2-(beta-carboxyethyl)-6-hydroxychroman (CEHC) via intermediate formation of 13'-hydroxychromanol and long-chain carboxychromanols. Conjugated (including sulfated) metabolites were reported previously but were limited to CEHCs.

Author(s): 
Jiang, Qing
Freiser, Helene
Wood, Karl V.
Yin, Xinmin
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

Cyclooxygenase (COX-1/COX-2)-catalyzed eicosanoid formation plays a key role in inflammation-associated diseases. Natural forms of vitamin E are recently shown to be metabolized to long-chain carboxychromanols and their sulfated counterparts. Here we find that vitamin E forms differentially inhibit COX-2-catalyzed prostaglandin E(2) in IL-1beta-stimulated A549 cells without affecting COX-2 expression, showing the relative potency of gamma-tocotrienol approximately delta-tocopherol > gamma-tocopherol > alpha- or beta-tocopherol.

Author(s): 
Jiang, Qing
Yin, Xinmin
Lill, Markus A.
Danielson, Matthew L.
Freiser, Helene
Huang, Jianjie
Publication Title: 
Analytical Biochemistry

Natural forms of vitamin E are metabolized by omega-hydroxylation and beta-oxidation of the hydrophobic side chain to generate urinary-excreted 2-(beta-carboxyethyl)-6-hydroxychroman (CEHC) and CEHC conjugates (sulfate, glucuronide, or glucoside). We recently showed that sulfated long-chain carboxychromanols, the conjugated intermediate beta-oxidation products, are formed from tocopherols and tocotrienols in human cells and in rats. CEHC conjugates have been quantified after being converted to its unconjugated counterpart by sulfatase/glucuronidase.

Author(s): 
Freiser, Helene
Jiang, Qing
Publication Title: 
The Journal of Nutrition

The metabolism of gamma-tocotrienol (gamma-TE) and gamma-tocopherol (gamma-T) was investigated in human A549 cells and in rats. Similar to gamma-T, A549 cells metabolized gamma-TE to sulfated 9'-, 11'-, and 13'-carboxychromanol and their unconjugated counterparts. After 72-h incubation with the cells, 90% of long-chain carboxychromanols in the culture media from gamma-TE, but <45% from gamma-T, were in the sulfated form.

Author(s): 
Freiser, Helene
Jiang, Qing
Publication Title: 
Journal of Chromatography. A

A general approach for discovering novel catabolic metabolites from a parent biocompound was developed and validated on the metabolism of gamma-tocopherol in human A549 cell. The method is based on LC-MS analysis of in vitro stable isotope-labeled metabolites and assumes that a parent compound and its metabolites share a common functional group that can be derivatized by well-documented reagents.

Author(s): 
Yang, Wen-Chu
Regnier, Fred E.
Jiang, Qing
Adamec, Jiri
Publication Title: 
Journal of Immunology (Baltimore, Md.: 1950)

Leukotrienes generated by 5-lipoxygenase (5-LOX)-catalyzed reaction are key regulators of inflammation. In ionophore-stimulated (A23187; 1-2.5 μM) human blood neutrophils or differentiated HL-60 cells, vitamin E forms differentially inhibited leukotriene B(4) (LTB(4)) with an IC(50) of 5-20 μM for γ-tocopherol, δ-tocopherol (δT), and γ-tocotrienol, but a much higher IC(50) for α-tocopherol.

Author(s): 
Jiang, Ziying
Yin, Xinmin
Jiang, Qing
Publication Title: 
Bioorganic & Medicinal Chemistry Letters

Chroman aldehydes bearing an acetyl group plus alkoxyl or hydroxyl groups inhibit HIV infectivity in HeLa37 cells.

Author(s): 
Kraus, George A.
Mengwasser, John
Maury, Wendy
Oh, ChoonSeok
Publication Title: 
International Journal of Cancer. Journal International Du Cancer

Although cell-based studies have shown that γ-tocotrienol (γTE) exhibits stronger anticancer activities than other forms of vitamin E including γ-tocopherol (γT), the molecular bases underlying γTE-exerted effects remains to be elucidated. Here we showed that γTE treatment promoted apoptosis, necrosis and autophagy in human prostate PC-3 and LNCaP cancer cells.

Author(s): 
Jiang, Qing
Rao, Xiayu
Kim, Choon Young
Freiser, Helene
Zhang, Qingbo
Jiang, Ziying
Li, Guilan

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