Chromatography, Liquid

Publication Title: 
Se Pu = Chinese Journal of Chromatography

The extracts from Chinese herbs are complex compounds with uncertain mechanism, which affects the target with all ingredients. Therefore, it is of great importance to evaluate the bioactivity of these extracts. In this study, 29 samples which had continuous variation of constituents were obtained from the alcohol extract of Terminalia chebula Retz. by a Sephadex LH-20 size exclusion chromatographic column.

Author(s): 
Wang, Dingying
Zhu, Jingbo
Ding, Yan
Kou, Zinong
Yang, Lanping
Publication Title: 
PloS One

The aging phenotype in humans has been thoroughly studied but a detailed metabolic profiling capable of shading light on the underpinning biological processes of longevity is still missing. Here using a combined metabonomics approach compromising holistic (1)H-NMR profiling and targeted MS approaches, we report for the first time the metabolic phenotype of longevity in a well characterized human aging cohort compromising mostly female centenarians, elderly, and young individuals.

Author(s): 
Collino, Sebastiano
Montoliu, Ivan
Martin, FranÁois-Pierre J.
Scherer, Max
Mari, Daniela
Salvioli, Stefano
Bucci, Laura
Ostan, Rita
Monti, Daniela
Biagi, Elena
Brigidi, Patrizia
Franceschi, Claudio
Rezzi, Serge
Publication Title: 
PloS One

The aging phenotype in humans has been thoroughly studied but a detailed metabolic profiling capable of shading light on the underpinning biological processes of longevity is still missing. Here using a combined metabonomics approach compromising holistic (1)H-NMR profiling and targeted MS approaches, we report for the first time the metabolic phenotype of longevity in a well characterized human aging cohort compromising mostly female centenarians, elderly, and young individuals.

Author(s): 
Collino, Sebastiano
Montoliu, Ivan
Martin, FranÁois-Pierre J.
Scherer, Max
Mari, Daniela
Salvioli, Stefano
Bucci, Laura
Ostan, Rita
Monti, Daniela
Biagi, Elena
Brigidi, Patrizia
Franceschi, Claudio
Rezzi, Serge
Publication Title: 
Molecular & cellular proteomics: MCP

Calorie restriction (CR) promotes longevity. A prevalent mechanistic hypothesis explaining this effect suggests that protein degradation, including mitochondrial autophagy, is increased with CR, removing damaged proteins and improving cellular fitness. At steady state, increased catabolism must be balanced by increasing mitochondrial biogenesis and protein synthesis, resulting in faster protein replacement rates.

Author(s): 
Price, John C.
Khambatta, Cyrus F.
Li, Kelvin W.
Bruss, Matthew D.
Shankaran, Mahalakshmi
Dalidd, Marcy
Floreani, Nicholas A.
Roberts, Lindsay S.
Turner, Scott M.
Holmes, William E.
Hellerstein, Marc K.
Publication Title: 
Molecular Psychiatry

Autism affects males more than females, giving rise to the idea that the influence of steroid hormones on early fetal brain development may be one important early biological risk factor.

Author(s): 
Baron-Cohen, S.
Auyeung, B.
N¯rgaard-Pedersen, B.
Hougaard, D. M.
Abdallah, M. W.
Melgaard, L.
Cohen, A. S.
Chakrabarti, B.
Ruta, L.
Lombardo, M. V.
Publication Title: 
Die Pharmazie

Propofol whole blood and plasma concentrations at offset of hypnosis in eighteen patients were inversely related to patient age and body fat. The relationship between propofol concentrations and body fat is derived from the relationship between age and body fat and age was the single independent predictor of concentrations at offset of propofol hypnosis.

Author(s): 
O'Halloran, P. L.
Hosseini-Yeganeh, M.
McBride, L. J.
Ramzan, I.
Publication Title: 
Journal of Pharmaceutical and Biomedical Analysis

Spinosin, a major bioactive herbal ingredient isolated from Semen Ziziphi Spinosae, plays an important role in sedation and hypnosis. However, the pharmacokinetic behavior of spinosin in special sites has not been reported. Microdialysis (MD) technique, as a continuous, realtime monitoring sampling technique, is very suitable for the evaluation of the disposition of diverse drugs.

Author(s): 
Ma, Rong-Hua
Yang, Jie
Qi, Lian-Wen
Xin, Gui-Zhong
Wang, Chong-Zhi
Yuan, Chun-Su
Wen, Xiao-Dong
Li, Ping
Publication Title: 
Drug Metabolism and Disposition: The Biological Fate of Chemicals

Five metabolites of the antimalarial piperaquine (PQ) (1,3-bis-[4-(7-chloroquinolyl-4)-piperazinyl-1]-propane) have been identified and their molecular structures characterized. After a p.o. dose of dihydroartemisinin-piperaquine, urine collected over 16 h from two healthy subjects was analyzed using liquid chromatography (LC)/UV, LC/tandem mass spectrometry (MS/MS), Fourier transform ion cyclotron resonance (FTICR)/MS, and H NMR.

Author(s): 
Tarning, J.
Bergqvist, Y.
Day, N. P.
Bergquist, J.
Arvidsson, B.
White, N. J.
Ashton, M.
Lindegardh, N.
Publication Title: 
Antimicrobial Agents and Chemotherapy

The in vivo alkylation of heme by the antimalarial trioxaquine DU1301 afforded covalent heme-drug adducts that were detected in the spleens of Plasmodium sp.-infected mice. This result indicates that the alkylation capacities of trioxaquines in mammals infected with Plasmodium strains are similar to that of artemisinin, a natural antimalarial trioxane-containing drug.

Author(s): 
Bousejra-El Garah, Fatima
Claparols, Catherine
Benoit-Vical, Françoise
Meunier, Bernard
Robert, Anne
Publication Title: 
Antimicrobial Agents and Chemotherapy

The two fixed-dose combinations of dihydroartemisinin and piperaquine (Artekin and Arterakine) were found to be bioinequivalent in healthy Vietnamese subjects. However, because the peak plasma concentrations and areas under the concentration-time curves of dihydroartemisinin and piperaquine were only marginally different between the two formulations, similar therapeutic efficacies are expected in the treatment of malaria infections.

Author(s): 
Chinh, Nguyen Trong
Quang, Nguyen Ngoc
Thanh, Nguyen Xuan
Dai, Bui
Geue, Jason P.
Addison, Russell S.
Travers, Thomas
Edstein, Michael D.

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