Chromosomes, Human, Pair 1

Publication Title: 
Nature Genetics

Osteoarthritis is the most common form of arthritis and is a major cause of pain and disability in the elderly. To search for sequence variants that confer risk of osteoarthritis of the hand, we carried out a genome-wide association study (GWAS) in subjects with severe hand osteoarthritis, using variants identified through the whole-genome sequencing of 2,230 Icelanders.

Author(s): 
Styrkarsdottir, Unnur
Thorleifsson, Gudmar
Helgadottir, Hafdis T.
Bomer, Nils
Metrustry, Sarah
Bierma-Zeinstra, S.
Strijbosch, Annelieke M.
Evangelou, Evangelos
Hart, Deborah
Beekman, Marian
Jonasdottir, Aslaug
Sigurdsson, Asgeir
Eiriksson, Finnur F.
Thorsteinsdottir, Margret
Frigge, Michael L.
Kong, Augustine
Gudjonsson, Sigurjon A.
Magnusson, Olafur T.
Masson, Gisli
TREAT-OA Consortium
arcOGEN Consortium
Hofman, Albert
Arden, Nigel K.
Ingvarsson, Thorvaldur
Lohmander, Stefan
Kloppenburg, Margreet
Rivadeneira, Fernando
Nelissen, Rob G. H. H.
Spector, Tim
Uitterlinden, Andre
Slagboom, P. Eline
Thorsteinsdottir, Unnur
Jonsdottir, Ingileif
Valdes, Ana M.
Meulenbelt, Ingrid
van Meurs, Joyce
Jonsson, Helgi
Stefansson, Kari
Publication Title: 
Journal of Human Genetics

Genetic studies of neuropsychiatric disorders have often produced conflicting results, which might partly result from the involvement of epigenetic modifications. We intended to explore the possible implication of DNA methylation and human endogenous retroviruses (HERVs) in neuropsychiatric disorders. In the present study, we identified two HERV loci that are expected to retain the transcriptional activity in the brain. One was located on chromosome 1q21-q22 and the other on 22q12.

Author(s): 
Nakamura, Akifumi
Okazaki, Yuji
Sugimoto, Jun
Oda, Takaya
Jinno, Yoshihiro
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