Cimicifuga

Publication Title: 
Menopause (New York, N.Y.)

OBJECTIVE: To systematically review the available data relating to the safety of medicinal extracts of black cohosh (Actaea racemosa). DESIGN: Systematic literature searches were conducted in seven electronic databases, and the reference lists of all papers located were checked for further relevant publications. Information was also sought from the spontaneous reporting programs of the World Health Organization and national drug safety bodies. Sixteen manufacturers of black cohosh preparations were contacted and asked for data held on file.

Author(s): 
Huntley, Alyson
Ernst, Edzard
Publication Title: 
Journal of Chromatography. A

Black cohosh has become one of the most important herbal products in the US dietary supplements market. It is manufactured from roots and rhizomes of Cimicifuga racemosa (Ranunculaceae). Botanical identification of the raw starting material is a key step in the quality control of black cohosh preparations. The present report summarizes a fingerprinting approach based on high performance liquid chromatography-photodiode array/mass spectrometric/evaporative light scattering detection (HPLC-PDA/MS/ELSD) that has been developed and validated using a total of 10 Cimicifuga species.

Author(s): 
He, Kan
Pauli, Guido F.
Zheng, Bolin
Wang, Huikang
Bai, Naisheng
Peng, Tangsheng
Roller, Marc
Zheng, Qunyi
Publication Title: 
Journal of Agricultural and Food Chemistry

Black cohosh (Actaea racemosa L., syn. Cimicifuga racemosa L.) has become increasingly popular as a dietary supplement in the United States for the treatment of symptoms related to menopause, but the botanical authenticity of most products containing black cohosh has not been evaluated, nor is manufacturing highly regulated in the United States.

Author(s): 
Jiang, Bei
Kronenberg, Fredi
Nuntanakorn, Paiboon
Qiu, Ming-Hua
Kennelly, Edward J.
Publication Title: 
Journal of Agricultural and Food Chemistry

Black cohosh is a commonly used botanical dietary supplement for the treatment of climacteric complaints. Because the opiate system in the brain is intimately associated with mood, temperature, and sex hormonal levels, the activity of black cohosh extracts at the human mu opiate receptor (hMOR) expressed in Chinese hamster ovary cells was investigated. The 100% methanol, 75% ethanol, and 40% 2-propanol extracts of black cohosh effectively displaced the specific binding of [3H]DAMGO to hMOR.

Author(s): 
Rhyu, Mee-Ra
Lu, Jian
Webster, Donna E.
Fabricant, Daniel S.
Farnsworth, Norman R.
Wang, Z. Jim
Publication Title: 
Anticancer Research

BACKGROUND: Previous studies indicate that specific extracts and the pure triterpene glycoside actein obtained from black cohosh inhibit growth of human breast cancer cells. Our aim is to identify alterations in gene expression induced by treatment with a methanolic extract (MeOH) of black cohosh. MATERIALS AND METHODS: We treated MDA-MB-453 human breast cancer cells with the MeOH extract at 40 microg/ml and collected RNA at 6 and 24 h; we confirmed the microarray results with real-time RT-PCR for 18 genes.

Author(s): 
Einbond, Linda Saxe
Su, Tao
Wu, Hsan-au
Friedman, Richard
Wang, Xiaomei
Jiang, Bei
Hagan, Timothy
Kennelly, Edward J.
Kronenberg, Fredi
Weinstein, I. Bernard
Publication Title: 
Journal of Natural Products

Extracts from the roots and rhizomes of black cohosh (Cimicifuga racemosa) are widely used as dietary supplements to alleviate menopausal symptoms. State-of-the-art quality control measures involve phytochemical fingerprinting of the triterpene glycosides for species identification and chemical standardization by HPLC. In the course of developing materials and methods for standardization procedures, the major C. racemosa triterpene glycoside (1) was isolated and initially thought to be cimicifugoside (2).

Author(s): 
Chen, Shao-Nong
Lankin, David C.
Nikolic, Dejan
Fabricant, Daniel S.
Lu, Zhi-Zhen
Ramirez, Benjamin
van Breemen, Richard B.
Fong, Harry H. S.
Farnsworth, Norman R.
Pauli, Guido F.
Publication Title: 
Chemistry & Biology

Osteoporosis is a major age-related source of morbidity and mortality. Increased bone resorption mediated by osteoclasts is central to its pathogenesis. Cytokines, particularly RANKL and TNFalpha, are often increased under pathologic conditions, leading to enhanced osteoclastogenesis. Black cohosh (Actaea/Cimicifuga racemosa L), a popular herbal supplement for the treatment of menopausal symptoms, was recently shown to have the beneficial effect of preventing bone loss.

Author(s): 
Qiu, Samuel X.
Dan, Chun
Ding, Li-Sheng
Peng, Shulin
Chen, Shao-Nong
Farnsworth, Norman R.
Nolta, Jan
Gross, Michael L.
Zhou, Ping
Publication Title: 
Phytomedicine: International Journal of Phytotherapy and Phytopharmacology

The purpose of this report is to explore the growth inhibitory effect of extracts and compounds from black cohosh and related Cimicifuga species on human breast cancer cells and to determine the nature of the active components. Black cohosh fractions enriched for triterpene glycosides and purified components from black cohosh and related Asian species were tested for growth inhibition of the ER(-) Her2 overexpressing human breast cancer cell line MDA-MB-453. Growth inhibitory activity was assayed using the Coulter Counter, MTT and colony formation assays.

Author(s): 
Einbond, Linda Saxe
Wen-Cai, Ye
He, Kan
Wu, Hsan-au
Cruz, Erica
Roller, Marc
Kronenberg, Fredi
Publication Title: 
The American Journal of Clinical Nutrition

The University of Illinois at Chicago/National Institutes of Health Center for Botanical Dietary Supplements Research began in 1999 with an emphasis on botanical dietary supplements for women's health. We have concentrated on plants that may improve women's health, especially to reduce hot flashes in menopausal women, alleviate the symptoms of premenstrual syndrome, and reduce persistent urinary tract infections.

Author(s): 
Farnsworth, Norman R.
Krause, Elizabeth C.
Bolton, Judy L.
Pauli, Guido F.
van Breemen, Richard B.
Graham, James G.
Publication Title: 
Menopause (New York, N.Y.)

OBJECTIVE: To test whether black cohosh (BC) exhibits an action on the central endogenous opioid system in postmenopausal women. DESIGN: This was a mechanistic study conducted in the same individuals of luteinizing hormone pulsatility with a saline/naloxone challenge (n = 6) and positron emission tomography with [C]carfentanil, a selective micro-opioid receptor radioligand (n = 5), before and after 12 weeks of unblinded treatment with a popular BC daily supplement.

Author(s): 
Reame, Nancy E.
Lukacs, Jane L.
Padmanabhan, Vasantha
Eyvazzadeh, Aimee D.
Smith, Yolanda R.
Zubieta, Jon-Kar

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