Cinnamates

Publication Title: 
The Journal of Biological Chemistry

We have determined the complete sequence of the nuclear gene encoding the small subunit (17 S) rRNA of the ciliated protozoan Tetrahymena thermophila. The gene encodes an RNA molecule which is 1753 nucleotides in length. The sequence of the Tetrahymena small subunit rRNA is homologous to those of other eukaryotes, and the predicted secondary structure for the molecule includes features which are characteristic of eukaryotic small subunit rRNAs.

Author(s): 
Spangler, E. A.
Blackburn, E. H.
Publication Title: 
The Journal of Biological Chemistry

We have determined the complete sequence of the nuclear gene encoding the small subunit (17 S) rRNA of the ciliated protozoan Tetrahymena thermophila. The gene encodes an RNA molecule which is 1753 nucleotides in length. The sequence of the Tetrahymena small subunit rRNA is homologous to those of other eukaryotes, and the predicted secondary structure for the molecule includes features which are characteristic of eukaryotic small subunit rRNAs.

Author(s): 
Spangler, E. A.
Blackburn, E. H.
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: It is well known that fragrance impacts behaviors and autonomic functions, and is increasingly used as relaxant, carminative, as well as sedative in aromatherapy. Kaempferia galanga L. is one of the popular traditional aromatic medicinal plants used in tropics and subtropics of Asia including China, Japan and Indochina.

Author(s): 
Huang, Linfang
Yagura, Toru
Chen, Shilin
Publication Title: 
Alternative Medicine Review: A Journal of Clinical Therapeutic

Picrorhiza kurroa is a well-known herb in the Ayurvedic system of medicine and has traditionally been used to treat disorders of the liver and upper respiratory tract, reduce fevers, and to treat dyspepsia, chronic diarrhea, and scorpion sting. It is a small perennial herb from the Scrophulariaceae family, found in the Himalayan region growing at elevations of 3,000 - 5,000 meters. Picrorhiza kurroa has a long, creeping rootstock that is bitter in taste, and grows in rock crevices and moist, sandy soil. The leaves of the plant are flat, oval, and sharply serrated.

Publication Title: 
Alternative Medicine Review: A Journal of Clinical Therapeutic

Picrorhiza kurroa is a well-known herb in the Ayurvedic system of medicine and has traditionally been used to treat disorders of the liver and upper respiratory tract, reduce fevers, and to treat dyspepsia, chronic diarrhea, and scorpion sting. It is a small perennial herb from the Scrophulariaceae family, found in the Himalayan region growing at elevations of 3,000 - 5,000 meters. Picrorhiza kurroa has a long, creeping rootstock that is bitter in taste, and grows in rock crevices and moist, sandy soil. The leaves of the plant are flat, oval, and sharply serrated.

Publication Title: 
Journal of Diabetes

BACKGROUND: Cinnamomum cassia (Family: Lauraceae) is an Ayurvedic medicinal plant used traditionally for the treatment of a number of diseases, including diabetes. The hypoglycemic effect of this plant has been established in vivo. However, the effects of cinnamic acid, isolated from C. cassia, on the insulin signaling cascade in an in vitro model have not been elucidated. Hence, the aim of the present study was to evaluate the anti-diabetic effect of cinnamic acid on glucose transport by L6 myotubes.

Author(s): 
Lakshmi, Baddireddi Subhadra
Sujatha, Sundaresan
Anand, Singaravelu
Sangeetha, Kadapakkam Nandhabalan
Narayanan, Rangarajan Badri
Katiyar, Chandrakanth
Kanaujia, Anil
Duggar, Rajeev
Singh, Yogendra
Srinivas, Konasubrahmanya
Bansal, Vinay
Sarin, Simi
Tandon, Ruchi
Sharma, Suchitra
Singh, Suchita
Publication Title: 
Journal of Natural Medicines

Picrorhiza kurrooa Royle ex Benth (Scrophulariaceae), commonly known as Kutki, is a major ingredient of many ayurvedic preparations prescribed in the treatment of various diseases. Picrosides I and II are the active agents responsible for the medicinal effects of Kutki, and the variation in content of these compounds in plants at different altitudes is a major question to be addressed. The picroside I and II content in various plant parts of P. kurrooa collected from different altitudes, viz.

Author(s): 
Katoch, Meenu
Fazli, I. S.
Suri, K. A.
Ahuja, A.
Qazi, G. N.
Publication Title: 
Fitoterapia

Many plants are used in Ayurveda for the treatment of tuberculosis. Our aim was to examine if these plants possess any specific molecule that inhibits Mycobacterium tuberculosis. One of them, Kaempferia galanga, yielded an anti-TB molecule, ethyl p-methoxycinnamate (EPMC). By resazurin microtitre assay (REMA), EPMC was shown to inhibit M. tuberculosis H37Ra, H37Rv, drug susceptible and multidrug resistant (MDR) clinical isolates (MIC 0.242-0.485mM). No cross resistance was observed to any standard anti-TB drugs in the MDR strains. The compound did not inhibit any prototype bacteria tested.

Author(s): 
Lakshmanan, Divya
Werngren, Jim
Jose, Leny
Suja, K. P.
Nair, Mangalam S.
Varma, R. Luxmi
Mundayoor, Sathish
Hoffner, Sven
Kumar, R. Ajay
Publication Title: 
Chemico-Biological Interactions

Cinnamic acid (C9H8O2), is a major constituent of the oriental Ayurvedic plant Cinnamomum cassia (Family: Lauraceae). This phenolic acid has been reported to possess various pharmacological properties of which its antioxidant activity is a prime one. Therefore it is rational to hypothesize that it may ameliorate myelosuppression and oxidative stress induced by cyclophosphamide, a widely used chemotherapeutic agent.

Author(s): 
Patra, Kartick
Bose, Samadrita
Sarkar, Shehnaz
Rakshit, Jyotirmoy
Jana, Samarjit
Mukherjee, Avik
Roy, Abhishek
Mandal, Deba Prasad
Bhattacharjee, Shamee
Publication Title: 
British Journal of Pharmacology

1. We previously reported that four new phenylpropanoid glycosides and six known cinnamate derivatives isolated from roots of Scrophularia buergeriana Miquel (Scrophulariaceae) protected cultured cortical neurons from neurotoxicity induced by glutamate. Here, we have investigated the structure-activity relationships in the phenylpropanoids using our primary culture system. 2. The alpha,beta-unsaturated ester moiety and the para-methoxy group in the phenylpropanoids appeared to play a vital role in neuroprotective activity.

Author(s): 
Kim, So Ra
Sung, Sang Hyun
Jang, Young Pyo
Markelonis, George J.
Oh, Tae H.
Kim, Young Choong

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