Citric Acid Cycle

Publication Title: 
Nature
Author(s): 
Lee, Siu Sylvia
Ruvkun, Gary
Publication Title: 
The Journal of Biological Chemistry

Caloric restriction (CR) markedly extends life span and improves the health of a broad number of species. Energy metabolism fundamentally contributes to the beneficial effects of CR, but the underlying mechanisms that are responsible for this effect remain enigmatic.

Author(s): 
Yuan, Yiyuan
Kadiyala, Chandra S.
Ching, Tsui-Ting
Hakimi, Parvin
Saha, Sudipto
Xu, Hua
Yuan, Chao
Mullangi, Vennela
Wang, Liwen
Fivenson, Elayne
Hanson, Richard W.
Ewing, Rob
Hsu, Ao-Lin
Miyagi, Masaru
Feng, Zhaoyang
Publication Title: 
Archives of Biochemistry and Biophysics
Author(s): 
Blackburn, E. H.
Hird, F. J.
Publication Title: 
International Journal of Molecular Sciences

Thapsia laciniata Rouy (Apiaceae) produces irregular and regular sesquiterpenoids with thapsane and guaiene carbon skeletons, as found in other Apiaceae species. A transcriptomic analysis utilizing Illumina next-generation sequencing enabled the identification of novel genes involved in the biosynthesis of terpenoids in Thapsia. From 66.78 million HQ paired-end reads obtained from T. laciniata roots, 64.58 million were assembled into 76,565 contigs (N50: 1261 bp). Seventeen contigs were annotated as terpene synthases and five of these were predicted to be sesquiterpene synthases.

Author(s): 
Drew, Damian Paul
Dueholm, Bjørn
Weitzel, Corinna
Zhang, Ye
Sensen, Christoph W.
Simonsen, Henrik Toft
Publication Title: 
The Journal of Pharmacy and Pharmacology

Semecarpus anacardium Linn. of the family Anacardiaceae has many applications in the Ayurvedic and Siddha systems of medicine. We have evaluated the effect of S. anacardium nut milk extract on carbohydrate metabolizing enzymes and mitochondrial tricarboxylic acid cycle and respiratory enzymes in liver and kidney mitochondria of dimethyl benzanthracene-induced mammary carcinoma in Sprague-Dawley rats.

Author(s): 
Arathi, G.
Sachdanandam, P.
Publication Title: 
The Biochemical Journal

Indy is a gene in Drosophila melanogaster which, when made dysfunctional, leads to an extension of the average adult life span of the organism. The present study was undertaken to clone the Indy gene-product and to establish its functional identity. We isolated a full-length Indy cDNA from a D. melanogaster cDNA library. The cDNA codes for a protein of 572 amino acids [( Drosophila Indy (drIndy)]. In its amino acid sequence, drIndy exhibits comparable similarity to the two known Na(+)-coupled dicarboxylate transporters in mammals; namely, NaDC1 (35% identity) and NaDC3 (34% identity).

Author(s): 
Inoue, Katsuhisa
Fei, You-Jun
Huang, Wei
Zhuang, Lina
Chen, Zhong
Ganapathy, Vadivel
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

Caloric restriction extends life span in a variety of species, highlighting the importance of energy balance in aging. A new longevity gene, Indy (for I'm not dead yet), which doubles the average life span of flies without a loss of fertility or physical activity, was postulated to extend life by affecting intermediary metabolism.

Author(s): 
Knauf, Felix
Rogina, Blanka
Jiang, Zhirong
Aronson, Peter S.
Helfand, Stephen L.
Publication Title: 
Aging Cell

Caloric restriction, leanness and decreased activity of insulin/insulin-like growth factor 1 (IGF-1) receptor signaling are associated with increased longevity in a wide range of organisms from Caenorhabditis elegans to humans. Fat-specific insulin receptor knock-out (FIRKO) mice represent an interesting dichotomy, with leanness and increased lifespan, despite normal or increased food intake.

Author(s): 
Katic, Masa
Kennedy, Adam R.
Leykin, Igor
Norris, Andrew
McGettrick, Aileen
Gesta, Stephane
Russell, Steven J.
Bluher, Matthias
Maratos-Flier, Eleftheria
Kahn, C. Ronald
Publication Title: 
The Journal of Biological Chemistry

Caloric restriction (CR) markedly extends life span and improves the health of a broad number of species. Energy metabolism fundamentally contributes to the beneficial effects of CR, but the underlying mechanisms that are responsible for this effect remain enigmatic.

Author(s): 
Yuan, Yiyuan
Kadiyala, Chandra S.
Ching, Tsui-Ting
Hakimi, Parvin
Saha, Sudipto
Xu, Hua
Yuan, Chao
Mullangi, Vennela
Wang, Liwen
Fivenson, Elayne
Hanson, Richard W.
Ewing, Rob
Hsu, Ao-Lin
Miyagi, Masaru
Feng, Zhaoyang
Publication Title: 
PloS One

In the heart, lysine acetylation has been implicated in processes ranging from transcriptional control of pathological remodeling, to cardioprotection arising from caloric restriction. Given the emerging importance of this post-translational modification, we used a proteomic approach to investigate the broader role of lysine acetylation in the heart using a guinea pig model. Briefly, hearts were fractionated into myofilament-, mitochondrial- and cytosol-enriched fractions prior to proteolysis and affinity-enrichment of acetylated peptides.

Author(s): 
Foster, D. Brian
Liu, Ting
Rucker, Jasma
O'Meally, Robert N.
Devine, Lauren R.
Cole, Robert N.
O'Rourke, Brian
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