In vitro anticandidal activity of methanol extracts of 42 plant species of 29 families used in Iranian folkloric medicine were evaluated at 20 mg/ml concentration against Clotrimazole-resistant Candida albicans. Nineteen plant species in 16 families showed anticandidal activities. The lowest MIC of 0.62 mg/ml belonged to Terminalia chebula and Thymus vulgaris.
Archives Internationales De Pharmacodynamie Et De Thérapie
The interaction of four imidazole antimycotics clotrimazole, econazole, ketoconazole and miconazole with other drugs was studied in in vivo models known to reveal inhibition and induction of microsomal enzymes. In rats the duration of methohexital hypnosis and the prothrombin time prolongation induced by acenocoumarol were changed after oral administration of all four antimycotics. The oral ED50-values of miconazole, econazole and clotrimazole for prolongation of methohexital hypnosis in female rats (acute inhibiton of microsomal enzymes) were 3.55, 3.56 and 10.7 mg/kg.
The American Journal of Tropical Medicine and Hygiene
Currently available artemisinin-based combination therapies (ACTs) for malaria are inadequate. There remains an enormous unmet need for alternate artemisinin-based combination therapies. One of the fastest methods to identify promising artemisinin-based combination therapies is to look for synergistic or additive antimalarial interaction between artemisinin and an alternate drug against P. falciparum in vitro. Amphotericin B and clotrimazole are known drugs for treatment of human fungal infections.