Clusterin

Publication Title: 
Biochemical and Biophysical Research Communications

Clusterin is a disulfide-linked heterodimeric glycoprotein that has been implicated in a variety of biological processes. Its expression has been shown to be elevated during cellular senescence and normal aging, but it is uncertain whether clusterin protects against aging or whether its expression is a consequence of aging. To investigate the functions of clusterin during organismal aging, we established transgenic Drosophila alleles to induce the expression of the secretory form of human clusterin (hClu(S)) using the Gal4/UAS system.

Author(s): 
Lee, Young-Nam
Shim, Young-Jun
Kang, Byeong-Ho
Park, Joong-Jean
Min, Bon-Hong
Publication Title: 
Journal of Lipid Research

Caloric restriction (CR) has been shown to attenuate age-related oxidative damage and to improve major atherosclerotic risk factors. Paraoxonase 1 (PON1), an enzyme specifically associated with HDL containing apolipoproteins A-I and J, has been reported to prevent the proatherosclerotic effects of oxidized LDL. The aim of this study was to evaluate whether modulation of PON1 activity is part of the underlying CR mechanisms that attenuate the age-associated negative effects.

Author(s): 
Thomàs-Moyà, Elena
Gianotti, Magdalena
Proenza, Ana M.
Lladó, Isabel
Publication Title: 
The Journal of Clinical Endocrinology and Metabolism

OBJECTIVE: Obesity and type 2 diabetes are associated with an increase in the incidence and prevalence of Alzheimer's disease (AD) and an impaired cognitive function. Because peripheral blood mononuclear cells (MNC) express amyloid precursor protein (APP), the precursor of β-amyloid, which forms the pathognomonic plaques in the brain, we hypothesized that APP expression diminishes after the marked caloric restriction and weight loss associated with Roux-en-Y gastric bypass (RYGB) surgery.

Author(s): 
Ghanim, Husam
Monte, Scott V.
Sia, Chang Ling
Abuaysheh, Sanaa
Green, Kelly
Caruana, Joseph A.
Dandona, Paresh
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