Co-Repressor Proteins

Publication Title: 
Nature

Rett syndrome (RTT) is an X-linked human neurodevelopmental disorder with features of autism and severe neurological dysfunction in females. RTT is caused by mutations in methyl-CpG-binding protein 2 (MeCP2), a nuclear protein that, in neurons, regulates transcription, is expressed at high levels similar to that of histones, and binds to methylated cytosines broadly across the genome. By phosphotryptic mapping, we identify three sites (S86, S274 and T308) of activity-dependent MeCP2 phosphorylation.

Author(s): 
Ebert, Daniel H.
Gabel, Harrison W.
Robinson, Nathaniel D.
Kastan, Nathaniel R.
Hu, Linda S.
Cohen, Sonia
Navarro, Adrija J.
Lyst, Matthew J.
Ekiert, Robert
Bird, Adrian P.
Greenberg, Michael E.
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