Cognitive Reserve

Publication Title: 
Restorative Neurology and Neuroscience

PURPOSE: Cognitive impairment is one of the most disabling symptoms of multiple sclerosis (MS), affecting a large proportion of patients and having a severe impact on their quality of life. Nevertheless, there exists a large variability in the neuropsychological profiles of MS patients and some of them appear to withstand better than others the MS-related brain pathology before showing cognitive decline.

Author(s): 
Crescentini, Cristiano
Urgesi, Cosimo
Fabbro, Franco
Eleopra, Roberto
Publication Title: 
Restorative Neurology and Neuroscience

PURPOSE: Cognitive impairment is one of the most disabling symptoms of multiple sclerosis (MS), affecting a large proportion of patients and having a severe impact on their quality of life. Nevertheless, there exists a large variability in the neuropsychological profiles of MS patients and some of them appear to withstand better than others the MS-related brain pathology before showing cognitive decline.

Author(s): 
Crescentini, Cristiano
Urgesi, Cosimo
Fabbro, Franco
Eleopra, Roberto
Publication Title: 
Neuropsychologia

Cognitive reserve is hypothesized to help people withstand greater brain pathology without manifesting clinical symptoms, and may be regarded as a preventive factor of dementia. It is unclear whether the effect of cognitive reserve is evident only among the older adults or after conversion to dementia, or if it can also be seen earlier in life before the prominent effects of cognitive aging become apparent.

Author(s): 
Vuoksimaa, Eero
Panizzon, Matthew S.
Chen, Chi-Hua
Eyler, Lisa T.
Fennema-Notestine, Christine
Fiecas, Mark Joseph A.
Fischl, Bruce
Franz, Carol E.
Grant, Michael D.
Jak, Amy J.
Lyons, Michael J.
Neale, Michael C.
Thompson, Wesley K.
Tsuang, Ming T.
Xian, Hong
Dale, Anders M.
Kremen, William S.
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