Colonic Neoplasms

Publication Title: 
European Journal of Gastroenterology & Hepatology

In populations in sub-Saharan Africa, transitional changes in patterns of morbidity and mortality are taking place, with decreases in the diseases of poverty and infection, but rises in chronic diseases of prosperity, associated, however, with greater longevity. Remarkably, bowel diseases - appendicitis, diverticular disease, colon cancer - while nearly absent in rural areas, have very low incidences in urban dwellers, despite rises in risk factors, including a decreasing intake of fibre-containing foods.

Walker, A. R.
Segal, I.
Publication Title: 
Health News (Waltham, Mass.)
Blackburn, George L.
Publication Title: 
PloS One

Numerous longevity genes have been discovered in model organisms and altering their function results in prolonged lifespan. In mammals, some have speculated that any health benefits derived from manipulating these same pathways might be offset by increased cancer risk on account of their propensity to boost cell survival. The Sir2/SIRT1 family of NAD(+)-dependent deacetylases is proposed to underlie the health benefits of calorie restriction (CR), a diet that broadly suppresses cancer in mammals.

Firestein, Ron
Blander, Gil
Michan, Shaday
Oberdoerffer, Philipp
Ogino, Shuji
Campbell, Jennifer
Bhimavarapu, Anupama
Luikenhuis, Sandra
de Cabo, Rafael
Fuchs, Charles
Hahn, William C.
Guarente, Leonard P.
Sinclair, David A.
Publication Title: 
Patient Education and Counseling

This study identified participants' reasons for good, marginal or poor adherence, or withdrawing from community-based clinical studies using a dietary and/or drug intervention. Adults aged 48-75 years participated in one of three studies related to decreasing colon polyp recurrence. Qualitative data from progress notes (N = 675) and end-of-study evaluations (N = 87) were coded using constant comparative analysis with 100% content validity panel agreement.

Atwood, J. R.
Haase, J.
Rees-McGee, S.
Blackwell, G.
Giordano, L.
Earnest, D.
Alberts, D.
Sheehan, E.
Benedict, J.
Aickin, M.
Publication Title: 
Molecular Pharmacology

Doxorubicin efficacy in cancer therapy is hampered by the dose-dependent side effects, which may be overcome by reducing the drug's dose and increasing its efficacy. In the present work, we suggest that the activation of the nuclear factor-kappaB (NF-kappaB) pathway and of nitric-oxide (NO) synthase increases the doxorubicin efficacy in human colon cancer HT29 cells.

Riganti, Chiara
Doublier, Sophie
Costamagna, Costanzo
Aldieri, Elisabetta
Pescarmona, Gianpiero
Ghigo, Dario
Bosia, Amalia
Publication Title: 
British Journal of Pharmacology

BACKGROUND AND PURPOSE: Artemisinin is an antimalarial drug exerting pleiotropic effects, such as the inhibition of the transcription factor nuclear factor-kappa B and of the sarcoplasmic/endoplasmic reticulum Ca(++)-ATPase (SERCA) of P. falciparum.

Riganti, C.
Doublier, S.
Viarisio, D.
Miraglia, E.
Pescarmona, G.
Ghigo, D.
Bosia, A.
Publication Title: 
Molecules (Basel, Switzerland)

Development of novel therapy strategies is one of the major pressing topics of clinical oncology to overcome drug resistance of tumors. Artesunate (ART) is an anti-malarial drug, which also exerts profound cytotoxic activity towards cancer cells. We applied a gene-hunting approach using microarray-based transcriptome-wide mRNA expression profiling and COMPARE analyses. We identified a set of genes, whose expression was associated either with high IC50 values or low IC50 values for ART.

Sertel, Serkan
Eichhorn, Tolga
Simon, Christian H.
Plinkert, Peter K.
Johnson, Steven W.
Efferth, Thomas
Publication Title: 
Tumour Biology: The Journal of the International Society for Oncodevelopmental Biology and Medicine

Carcinoembryonic antigen (CEA) was purified from GW-39 human tumor xenografts in hamsters by immunoaffinity chromatography. Binding of the antigen to immobilized monoclonal antibody provided a high degree of purification of CEA in a single step. A recovery of 79% and a 750-fold purification were obtained. The purified CEA has a molecular size of 180 kilodaltons, an isoelectric point of 4.4, and a specific activity of 0.94. About 73% of the radiolabeled GW-39 CEA reacted with goat anti-CEA serum.

Tu, Y. Y.
Primus, F. J.
Shochat, D.
Goldenberg, D. M.
Publication Title: 
Hu Li Za Zhi The Journal of Nursing

Hemodialysis patients usually have a sense of hopelessness. This can affect their physical, mental and spiritual health, and can even be life- threatening. This article discusses a nursing experience involving a dialysis patient who also suffered from cancer had and a sense of hopelessness due to the distress caused by the two severe illnesses. The author assessed the patient by means of Roy's theory during the nursing period (5/7/2005-6/18/2005). Data were collected through physical assessments, interviews, observation of interaction with family members and a medical history review.

Yeh, Shih-Chun
Yeh, Hui-Fang
Publication Title: 
International Journal of Oncology

We previously established a bioassay method to screen for compounds that activate the promoter activity of p21(WAF1/CIP1), a potent inhibitor of cyclin-dependent kinases, in a p53-independent manner. As an activator of p21(WAF1/CIP1) promoter activity, we isolated cryptolepine (CLP: 5-methyl indolo (2,3b)-quiniine), an indoloquinoline alkaloid, from the traditional Ayurvedic medicinal plant Sida cordifolia. We show here that CLP induces the expression of p21(WAF1/CIP1) with growth arrest in p53-mutated human osteosarcoma MG63 cells.

Matsui, Taka-aki
Sowa, Yoshihiro
Murata, Hiroaki
Takagi, Koichi
Nakanishi, Ryoko
Aoki, Shunji
Yoshikawa, Masayuki
Kobayashi, Motomasa
Sakabe, Tomoya
Kubo, Toshikazu
Sakai, Toshiyuki


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