Comparative Effectiveness Research

Publication Title: 
The Medical Journal of Australia

OBJECTIVE: To review the literature on the comparative efficacy of psychological, behavioural and medical therapies for acrophobia (fear of heights). DATA SOURCES: Multiple databases were searched through the Cochrane Common Mental Disorders review group on 1 December 2015. DATA SYNTHESIS: The data were extracted independently and were pooled using RevMan version 5.3.5.

Author(s): 
Arroll, Bruce
Wallace, Henry B.
Mount, Vicki
Humm, Stephen P.
Kingsford, Douglas W.
Publication Title: 
The Oncologist

BACKGROUND: In this paper, we provide background and context regarding the potential for a new data-sharing platform, the Project Data Sphere (PDS) initiative, funded by financial and in-kind contributions from the CEO Roundtable on Cancer, to transform cancer research and improve patient outcomes. Given the relatively modest decline in cancer death rates over the past several years, a new research paradigm is needed to accelerate therapeutic approaches for oncologic diseases.

Author(s): 
Green, Angela K.
Reeder-Hayes, Katherine E.
Corty, Robert W.
Basch, Ethan
Milowsky, Mathew I.
Dusetzina, Stacie B.
Bennett, Antonia V.
Wood, William A.
Publication Title: 
Trials

BACKGROUND: Traditional Indian Ayurvedic medicine uses complex treatment approaches, including manual therapies, lifestyle and nutritional advice, dietary supplements, medication, yoga, and purification techniques. Ayurvedic strategies are often used to treat osteoarthritis (OA) of the knee; however, no systematic data are available on their effectiveness in comparison with standard care. The aim of this study is to evaluate the effectiveness of complex Ayurvedic treatment in comparison with conventional methods of treating OA symptoms in patients with knee osteoarthritis.

Author(s): 
Witt, Claudia M.
Michalsen, Andreas
Roll, Stephanie
Morandi, Antonio
Gupta, Shivnarain
Rosenberg, Mark
Kronpass, Ludwig
Stapelfeldt, Elmar
Hissar, Syed
Müller, Matthias
Kessler, Christian
Publication Title: 
Trials

BACKGROUND: Traditional Indian Ayurvedic medicine uses complex treatment approaches, including manual therapies, lifestyle and nutritional advice, dietary supplements, medication, yoga, and purification techniques. Ayurvedic strategies are often used to treat osteoarthritis (OA) of the knee; however, no systematic data are available on their effectiveness in comparison with standard care. The aim of this study is to evaluate the effectiveness of complex Ayurvedic treatment in comparison with conventional methods of treating OA symptoms in patients with knee osteoarthritis.

Author(s): 
Witt, Claudia M.
Michalsen, Andreas
Roll, Stephanie
Morandi, Antonio
Gupta, Shivnarain
Rosenberg, Mark
Kronpass, Ludwig
Stapelfeldt, Elmar
Hissar, Syed
Müller, Matthias
Kessler, Christian
Publication Title: 
Trials

BACKGROUND: Traditional Indian Ayurvedic medicine uses complex treatment approaches, including manual therapies, lifestyle and nutritional advice, dietary supplements, medication, yoga, and purification techniques. Ayurvedic strategies are often used to treat osteoarthritis (OA) of the knee; however, no systematic data are available on their effectiveness in comparison with standard care. The aim of this study is to evaluate the effectiveness of complex Ayurvedic treatment in comparison with conventional methods of treating OA symptoms in patients with knee osteoarthritis.

Author(s): 
Witt, Claudia M.
Michalsen, Andreas
Roll, Stephanie
Morandi, Antonio
Gupta, Shivnarain
Rosenberg, Mark
Kronpass, Ludwig
Stapelfeldt, Elmar
Hissar, Syed
Müller, Matthias
Kessler, Christian
Publication Title: 
Health and Quality of Life Outcomes

OBJECTIVE: Psoriatic arthritis (PsA) and scleroderma (SSc) are chronic rheumatic disorders with detrimental effects on health-related quality of life. Our objective was to assess health values (utilities) from the general public for health states common to people with PsA and SSc for economic evaluations.

Author(s): 
Khanna, Dinesh
Frech, Tracy
Khanna, Puja P.
Kaplan, Robert M.
Eckman, Mark H.
Hays, Ron D.
Ginsburg, Shaari S.
Leonard, Anthony C.
Tsevat, Joel
Publication Title: 
PloS One

BACKGROUND: For Comparative Effectiveness Research (CER) there is a need to develop scales for appraisal of available clinical research. Aims were to 1) test the feasibility of applying the pragmatic-explanatory continuum indicator summary tool and the six CER defining characteristics of the Institute of Medicine to RCTs of acupuncture for treatment of low back pain, and 2) evaluate the extent to which the evidence from these RCTs is relevant to clinical and health policy decision making.

Author(s): 
Witt, Claudia M.
Manheimer, Eric
Hammerschlag, Richard
Lüdtke, Rainer
Lao, Lixing
Tunis, Sean R.
Berman, Brian M.
Publication Title: 
North Carolina Medical Journal

The current clinical research system does not produce high-quality evidence quickly enough to support health care decision making. The Patient-Centered Outcomes Research Network (PCORnet) embodies a novel strategy for creating a national "network of networks" that is capable of significantly accelerating evidence generation to support a learning health system.

Author(s): 
Califf, Robert M.
Publication Title: 
Journal of Manipulative and Physiological Therapeutics

The purpose of this article is to discuss comparative effectiveness research (CER) as it relates to the chiropractic profession. This article reviews CER priorities as determined by the Institute of Medicine and suggests actions for the chiropractic profession to become more involved in CER.

Author(s): 
Johnson, Claire
Publication Title: 
BMC medical research methodology

BACKGROUND: Several methodological issues with non-randomized comparative clinical studies have been raised, one of which is whether the methods used can adequately identify uncertainties that evolve dynamically with time in real-world systems. The objective of this study is to compare the effectiveness of different combinations of Traditional Chinese Medicine (TCM) treatments and combinations of TCM and Western medicine interventions in patients with acute ischemic stroke (AIS) by using Markov decision process (MDP) theory.

Author(s): 
Wu, Darong
Cai, Yefeng
Cai, Jianxiong
Liu, Qiuli
Zhao, Yuanqi
Cai, Jingheng
Zhao, Min
Huang, Yonghui
Ye, Liuer
Lu, Yubo
Guo, Xianping

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