Complex Mixtures

Publication Title: 
Annali dell'Istituto Superiore Di Sanita

The use of a complementary medicine approach, and specifically of the popular medicine Oscillococcinum, for the treatment of influenza-like syndromes remains controversial. This brief paper analyses the currently available literature on this homeopathic preparation and the Cochrane Collaboration's 2006 systematic review, along with other recent studies, in order to clarify certain fundamental aspects of its use in the treatment of influenza.

Author(s): 
Marrari, Luigi Alberto
Terzan, Laurence
Chaufferin, Gilles
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Shilajit is a multi-component natural occurring mineral substance used in Ayurveda and Siddha systems of medicine which originated in India. Its source can be traced to the mountainous regions, where the hilly tribes first identified its beneficial use. Shilajit is aptly referred to as 'rasayana'/'rasayanam' in Ayurveda and Siddha literature which means rejuvenator because it prevents ailment and enhances the quality of life.

Author(s): 
Wilson, Eugene
Rajamanickam, G. Victor
Dubey, G. Prasad
Klose, Petra
Musial, Frauke
Saha, F. Joyonto
Rampp, Thomas
Michalsen, Andreas
Dobos, Gustav J.
Publication Title: 
Immunopharmacology and Immunotoxicology

The present study was aimed to establish the efficacy of Jeevaneeya Rasayana (JR), an ayurvedic polyherbal formulation, in adjuvant-induced arthritic (AIA) rat model with reference to mediators of inflammation. The methanolic (MJR), ethanolic (EJR), and water extracts (WJR) of JR were prepared and their anti-inflammatory activity in carrageenan-induced acute model was evaluated. MJR at a dose of 25 mg/kg showed significantly higher anti-inflammatory effect than EJR, WJR, and standard drug diclofenac. MJR also significantly decreased the paw edema in AIA rats.

Author(s): 
Shyni, G. L.
Ratheesh, M.
Sindhu, G.
Helen, A.
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Shilajit is a multi-component natural occurring mineral substance used in Ayurveda and Siddha systems of medicine which originated in India. Its source can be traced to the mountainous regions, where the hilly tribes first identified its beneficial use. Shilajit is aptly referred to as 'rasayana'/'rasayanam' in Ayurveda and Siddha literature which means rejuvenator because it prevents ailment and enhances the quality of life.

Author(s): 
Wilson, Eugene
Rajamanickam, G. Victor
Dubey, G. Prasad
Klose, Petra
Musial, Frauke
Saha, F. Joyonto
Rampp, Thomas
Michalsen, Andreas
Dobos, Gustav J.
Publication Title: 
In Vivo (Athens, Greece)

Cancer prevention studies were conducted with VPS, a hot water extract of the Coriolus versicolor (CV) mushroom, in female Swiss mice. The extract was administered in the diet for life to the animals. Three groups of mice received the following treatments: a). 1,2-dimethylhydrazine dihydrochloride (1,2-DMH) was administered as 10 weekly subcutaneous injections of 20 microg/g body weight, starting at 9 weeks of age; b). VPS was given at a 2% dose level starting at 7 weeks of age followed by 1,2-DMH, as described in group a; c).

Author(s): 
Coles, Melissa
Toth, Bela
Publication Title: 
Fitoterapia

The majority of bioactive principles in a complex matrix such as natural products and botanical medicines are secondary rather than primary metabolites. In addition to being chemically diverse, the bioactivity of an ethnobotanical can comprise from one to several bioactive compounds, present in a complex mixture. Conventional discovery efforts utilize bioassay-guided fractionation (BGF) to isolate individual active compounds. When applied to complex natural products, BGF is often challenged by an apparent loss of activity during fractionation, resulting in weakly active isolated compounds.

Author(s): 
Inui, Taichi
Wang, Yuehong
Pro, Samuel M.
Franzblau, Scott G.
Pauli, Guido F.
Publication Title: 
Voprosy Kurortologii, Fizioterapii, I Lechebnoĭ Fizicheskoĭ Kultury

We have developed the method for the treatment of the patients presenting with arterial hypertension and concomitant chronic psychoemothional overtension. The method consists of the application of the baths containing the Siberian Stag velvet antler extracts in combination with exercise therapy and massage. A total of 35 patients with arterial hypertension and concomitant chronic psychoemothional overtension were enrolled in the study.

Author(s): 
Antipova, I. I.
Smirnova, I. N.
Barabash, L. V.
Naumov, A. O.
Dostovalova, O. V.
Kuleshova, N. I.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The efficacy of homeopathy is controversial. Homeopathic remedies are made via iterated shaking and dilution, in ethanol or in water, from a starting substance. Remedies of potency 12 C or higher are ultra-dilute (UD), i.e. contain zero molecules of the starting material. Various hypotheses have been advanced to explain how a UD remedy might be different from unprepared solvent. One such hypothesis posits that a remedy contains stable clusters, i.e. localized regions where one or more hydrogen bonds remain fixed on a long time scale.

Author(s): 
Anick, David J.
Publication Title: 
Homeopathy: The Journal of the Faculty of Homeopathy

The 'silica hypothesis' is one of several frameworks that have been put forward to explain how homeopathic remedies, which often are diluted beyond the point where any of the original substance remains, might still be clinically effective. We describe here what the silica hypothesis says.

Author(s): 
Anick, David J.
Ives, John A.
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: The pharmacological activity of geopropolis collected by stingless bees (important and threatened pollinators), a product widely used in folk medicine by several communities in Brazil, especially in the Northeast Region, needs to be studied. OBJECTIVE: The aim of this study was to evaluate the antinociceptive activity of Melipona scutellaris geopropolis (stingless bee) using different models of nociception.

Author(s): 
Franchin, Marcelo
da Cunha, Marcos Guilherme
Denny, Carina
Napimoga, Marcelo Henrique
Cunha, Thiago Mattar
Koo, Hyun
de Alencar, Severino Matias
Ikegaki, Masaharu
Rosalen, Pedro Luiz

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