Contact Inhibition

Publication Title: 
Nature

The naked mole rat (Heterocephalus glaber) displays exceptional longevity, with a maximum lifespan exceeding 30?years. This is the longest reported lifespan for a rodent species and is especially striking considering the small body mass of the naked mole rat. In comparison, a similarly sized house mouse has a maximum lifespan of 4?years. In addition to their longevity, naked mole rats show an unusual resistance to cancer. Multi-year observations of large naked mole-rat colonies did not detect a single incidence of cancer.

Author(s): 
Tian, Xiao
Azpurua, Jorge
Hine, Christopher
Vaidya, Amita
Myakishev-Rempel, Max
Ablaeva, Julia
Mao, Zhiyong
Nevo, Eviatar
Gorbunova, Vera
Seluanov, Andrei
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

Blind mole rats Spalax (BMR) are small subterranean rodents common in the Middle East. BMR is distinguished by its adaptations to life underground, remarkable longevity (with a maximum documented lifespan of 21 y), and resistance to cancer. Spontaneous tumors have never been observed in spalacids. To understand the mechanisms responsible for this resistance, we examined the growth of BMR fibroblasts in vitro of the species Spalax judaei and Spalax golani.

Author(s): 
Gorbunova, Vera
Hine, Christopher
Tian, Xiao
Ablaeva, Julia
Gudkov, Andrei V.
Nevo, Eviatar
Seluanov, Andrei
Publication Title: 
Nature

The naked mole rat (Heterocephalus glaber) displays exceptional longevity, with a maximum lifespan exceeding 30?years. This is the longest reported lifespan for a rodent species and is especially striking considering the small body mass of the naked mole rat. In comparison, a similarly sized house mouse has a maximum lifespan of 4?years. In addition to their longevity, naked mole rats show an unusual resistance to cancer. Multi-year observations of large naked mole-rat colonies did not detect a single incidence of cancer.

Author(s): 
Tian, Xiao
Azpurua, Jorge
Hine, Christopher
Vaidya, Amita
Myakishev-Rempel, Max
Ablaeva, Julia
Mao, Zhiyong
Nevo, Eviatar
Gorbunova, Vera
Seluanov, Andrei
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