Cornea

Publication Title: 
Ophthalmology

Neuropathic pain is caused by a primary lesion or dysfunction of the nervous system and can occur in the cornea. However, neuropathic corneal pain (NCP) is currently an ill-defined disease. Patients with NCP are extremely challenging to manage, and evidence-based clinical recommendations for the management of patients with NCP are scarce. The objectives of this review are to provide guidelines for diagnosis and treatment of patients with NCP and to summarize current evidence-based literature in this area.

Author(s): 
Dieckmann, Gabriela
Goyal, Sunali
Hamrah, Pedram
Publication Title: 
Journal of Health Communication

This study examined the mediated influence of a celebrated religious hero in South Korea, Cardinal Stephen Kim, through two forms of involvement--parasocial interaction and identification--on intention toward cornea donation and volunteerism, and it investigated how the news media diffused of his death.

Author(s): 
Bae, Hyuhn-Suhck
Brown, William J.
Kang, Seok
Publication Title: 
La Semana Médica
Author(s): 
Paez Allende, F.
Publication Title: 
American Journal of Ophthalmology

To determine the effectiveness of hypnotic suggestion in eliminating unnecessary movement by the patient during surgery and to reduce postoperative discomfort, we assigned 59 patients undergoing radial keratotomy for the first time (32 men and 27 women ranging in age from 20 to 56 years; mean age, 30 years) to one of two groups. The first group (No. = 34) listened to a four-minute script designed to relax them just before undergoing surgery; the control group (No. = 25) received the same medications but did not hear the script.

Author(s): 
John, M. E.
Parrino, J. P.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The polyherbal eye drop (Itone™) is a mixture of aqueous distillates of nineteen traditionally used ingredients that sum up to impart potency to the formulation and make it a useful adjunct in various ocular pathologies. However, as there have been no controlled experimental studies accounting to the above claim, therefore, the present study was designed to evaluate the polyherbal formulation (PHF) for antiangiogenic, anti-inflammatory, anticataract, antioxidant and cytotoxicity in addition to the evaluation of intraocular penetration of PHF in rabbit eyes using LC-MS/MS.

Author(s): 
Velpandian, Thirumurthy
Gupta, Pankaj
Ravi, Alok Kumar
Sharma, Hanuman Prasad
Biswas, Nihar Ranjan
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The polyherbal eye drop (Itone™) is a mixture of aqueous distillates of nineteen traditionally used ingredients that sum up to impart potency to the formulation and make it a useful adjunct in various ocular pathologies. However, as there have been no controlled experimental studies accounting to the above claim, therefore, the present study was designed to evaluate the polyherbal formulation (PHF) for antiangiogenic, anti-inflammatory, anticataract, antioxidant and cytotoxicity in addition to the evaluation of intraocular penetration of PHF in rabbit eyes using LC-MS/MS.

Author(s): 
Velpandian, Thirumurthy
Gupta, Pankaj
Ravi, Alok Kumar
Sharma, Hanuman Prasad
Biswas, Nihar Ranjan
Publication Title: 
Investigative Ophthalmology & Visual Science

PURPOSE: sPLA2-IIa is a biomarker for many inflammatory diseases in humans and is found at high levels in human tears. However, its role in ocular surface inflammation remains unclear. An experimentally induced BALB/c mouse dry eye (DE) model was used to elucidate the role of sPLA2-IIa in ocular surface inflammation. METHODS: BALB/c mice were subcutaneously injected with scopolamine and placed in a daytime air-drying device for 5 to 10 days. Control mice received no treatment. DE status was evaluated with tear production with a phenol-red thread method.

Author(s): 
Wei, Yi
Epstein, Seth P.
Fukuoka, Shima
Birmingham, Neil P.
Li, Xiu-Min
Asbell, Penny A.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The objective of this study was to investigate the effects of the Brazilian Scaptotrigona sp propolis, a widely used folk medicine, in corneal wound healing and inflammation. METHODS: Corneal epithelial defects of 1 mm in diameter were made in the right eyes of Wistar male adult rats by cauterization with silver nitrate sticks. Subsequently, they were divided in two groups (n = 40 rats/group): Brazilian propolis (BP) group was topically treated with a microemulsion containing 1% Brazilian propolis; vehicle (VH) group received the same formulation without propolis.

Author(s): 
Martin, Luiz Fernando Taranta
Rocha, Eduardo Melani
Garcia, Sérgio Britto
Paula, Jayter Silva
Publication Title: 
Investigative Ophthalmology & Visual Science

PURPOSE: Extracts of the herb Tripterygium wilfordii hook f, the major component of which is triptolide, have been used in traditional Chinese medicine for the treatment of rheumatoid arthritis. Triptolide also exerts many other biological actions both in vitro and in vivo. The effect of this agent on collagen degradation by cultured corneal fibroblasts was examined. METHODS: Rabbit corneal fibroblasts were cultured in three-dimensional gels of type I collagen and in the absence or presence of interleukin (IL)-1beta or triptolide.

Author(s): 
Lu, Ying
Fukuda, Ken
Seki, Keisuke
Nakamura, Yoshikuni
Kumagai, Naoki
Nishida, Teruo
Publication Title: 
Molecular Vision

PURPOSE: Triptolide is a major component of the herb Tripterygium wilfordii Hook f, extracts of which are used in traditional Chinese medicine, and it has been found to possess immunosuppressive and anti-inflammatory properties. Viral infection of the cornea can lead to corneal ulceration and perforation as a result of collagen degradation in the corneal stroma.

Author(s): 
Kimura, Kazuhiro
Nomi, Norimasa
Yan, Zhou Hong
Orita, Tomoko
Nishida, Teruo

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