Coronary Circulation

Publication Title: 
International Journal of Cardiology

PURPOSE: It has been reported that mental stress is an independent risk factor for cardiovascular events and impairs coronary circulation. Lavender aromatherapy, one of the most popular complementary treatments, is recognized as a beneficial mental relaxation therapy. However, no study has examined the effect of this therapy on coronary circulation. We aimed to assess the effect of lavender aromatherapy on coronary circulation by measuring coronary flow velocity reserve (CFVR) with noninvasive transthoracic Doppler echocardiography (TTDE).

Author(s): 
Shiina, Yumi
Funabashi, Nobusada
Lee, Kwangho
Toyoda, Tomohiko
Sekine, Tai
Honjo, Sachiko
Hasegawa, Rei
Kawata, Takayuki
Wakatsuki, Yu
Hayashi, Shinichiro
Murakami, Shio
Koike, Kazuo
Daimon, Masao
Komuro, Issei
Publication Title: 
American Journal of Physiology. Heart and Circulatory Physiology

Bromelain (Br), a proteolytic enzyme extracted from the stem of the pineapple, is known to possess anti-inflammatory activity and has been shown to reduce blood viscosity, prevent the aggregation of blood platelets, and improve ischemia-reperfusion (I/R) injury in a skeletal muscle model. We investigated the capacity of Br to limit myocardial injury in a global I/R model. Adult male Sprague-Dawley rats were divided into two groups: control (PBS) and Br at 10 mg/kg in PBS administered via intraperitoneal injection (twice/day) for 15 consecutive days.

Author(s): 
Juhasz, Bela
Thirunavukkarasu, Mahesh
Pant, Rima
Zhan, Lijun
Penumathsa, Suresh Varma
Secor, Eric R.
Srivastava, Sapna
Raychaudhuri, Utpal
Menon, Venugopal P.
Otani, Hajime
Thrall, Roger S.
Maulik, Nilanjana
Publication Title: 
Journal of the American College of Cardiology

OBJECTIVES: We examined the effects of the flavanol (-)-epicatechin on short- and long-term infarct size and left ventricular (LV) structure and function after permanent coronary occlusion (PCO) and the potential involvement of the protective protein kinase B (AKT)/extracellular signal-related kinase (ERK) signaling pathways. BACKGROUND: (-)-epicatechin reduces blood pressure in hypertensive patients and limits infarct size in animal models of myocardial ischemia-reperfusion injury. However, nothing is known about its effects on infarction after PCO.

Author(s): 
Yamazaki, Katrina Go
Taub, Pam R.
Barraza-Hidalgo, Maraliz
Rivas, Maria M.
Zambon, Alexander C.
Ceballos, Guillermo
Villarreal, Francisco J.
Publication Title: 
Cardiovascular Diabetology

BACKGROUND: In the general population, peripheral metabolic complications (MC) increase the risk for left ventricular dysfunction. Human immunodeficiency virus infection (HIV) and combination anti-retroviral therapy (cART) are associated with MC, left ventricular dysfunction, and a higher incidence of cardiovascular events than the general population. We examined whether myocardial nutrient metabolism and left ventricular dysfunction are related to one another and worse in HIV infected men treated with cART vs. HIV-negative men with or without MC.

Author(s): 
Cade, W. Todd
Reeds, Dominic N.
Overton, E. Turner
Herrero, Pilar
Waggoner, Alan D.
Davila-Roman, Victor G.
Lassa-Claxton, Sherry
Gropler, Robert J.
Soto, Pablo F.
Krauss, Melissa J.
Yarasheski, Kevin E.
Peterson, Linda R.
Publication Title: 
Critical Care Medicine

OBJECTIVE: To compare the hemodynamics of closed-chest cardiac massage vs. open-chest cardiac massage in patients resuscitated from cardiac arrest that occurred outside of the hospital. DESIGN: Prospective, non-outcome, case series. SETTING: Large urban emergency department. PATIENTS: Ten adult, normothermic, nontraumatic, out-of-hospital, cardiac arrest patients who failed advanced cardiac life support (ACLS) therapy. INTERVENTIONS: Patients presenting to the hospital in cardiac arrest were managed according to the ACLS protocol at the clinician's discretion.

Author(s): 
Boczar, M. E.
Howard, M. A.
Rivers, E. P.
Martin, G. B.
Horst, H. M.
Lewandowski, C.
Tomlanovich, M. C.
Nowak, R. M.
Publication Title: 
Resuscitation

Recent studies have shown the potential adverse effects of venous volume loading on blood flow during closed chest cardiopulmonary resuscitation (CPR). To examine the effect of arterial and venous infusions, we employed a published computer simulation of the circulation during CPR. This model uses computer simulated electrical networks to model the heart and great vessels. CPR was modeled with compressions at a rate of 80/min and a force of 80 mmHg.

Author(s): 
Tomaszewski, C. A.
Meador, S. A.
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

BACKGROUND: The action of homeopathic medicines, in ultra-high dilution, is not directly observable. An attempt was made to explore autonomic response of selective homeopathic medicines, in healthy persons, using Medical Analyzer System (Electronics Division, Bhabha Atomic Research Centre, Mumbai, India). OBJECTIVE: The objective of the study was to observe the action of homeopathic medicines on physiologic variability of heart rate and blood flow.

Author(s): 
Mishra, Nirupama
Muraleedharan, K. Charan
Paranjpe, Akalpita Sriniwas
Munta, Devendra Kumar
Singh, Hari
Nayak, Chaturbhuja
Publication Title: 
American Journal of Physiology. Heart and Circulatory Physiology

Ischemic preconditioning (PC) has been proposed as an endogenous form of protection against-ischemia reperfusion injury. We have shown that PC does not prevent postischemic dysfunction in the aging heart. This phenomenon could be due to the reduction of cardiac norepinephrine release, and it has also been previously demonstrated that age-related decrease of norepinephrine release from cardiac adrenergic nerves may be restored by caloric restriction.

Author(s): 
Abete, Pasquale
Testa, Gianluca
Ferrara, Nicola
de Santis, Domenico
Capaccio, Pina
Viati, Luisa
Calabrese, Claudio
Cacciatore, Francesco
Longobardi, Giancarlo
Condorelli, Mario
Napoli, Claudio
Rengo, Franco
Publication Title: 
American Journal of Physiology. Heart and Circulatory Physiology

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States. Research has shown that the majority of the cardiometabolic alterations associated with an increased risk of CVD (e.g., insulin resistance/type 2 diabetes, abdominal obesity, dyslipidemia, hypertension, and inflammation) can be prevented, and even reversed, with the implementation of healthier diets and regular exercise.

Author(s): 
Weiss, Edward P.
Fontana, Luigi
Publication Title: 
Japanese Journal of Pharmacology

Cardiac effects of drugs used for circulatory disorders in traditional Japanese medicine based on ancient Chinese medicine (Kampo Medicine): Saikoka-ryukotsu-borei-to, Oren-gedoku-to, Toki-shakuyaku-san, Shimbu-to, Moku-boi-to, Ryo-kei-jutsu-kan-to, Sha-kanzo-to, Keishi-ninjin-to, Toki-to and Ryo-kan-kyo-mi-shin-ge-nin-to were investigated using canine isolated, blood-perfused sinoatrial node and papillary muscle preparations.

Author(s): 
Sugiyama, A.
Hashimoto, K.

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