Corticosterone

Publication Title: 
Biological & Pharmaceutical Bulletin

Immune activation is an effective as well as protective approach against emerging infectious diseases. The immunomodulatory activities of Triphala (Terminalia chebula, Terminalia belerica and Emblica officinalis) were assessed by testing the various neutrophil functions like adherence, phagocytosis (phagocytic index (P.I) and avidity index (A.I)) and nitro blue tetrazolium (NBT) reduction in albino rats. In recent years much attention is being focused on the immunological changes occur during stress. Noise (100 dB) stress for 4 h/d for 15 d, was employed to alter the neutrophil functions.

Author(s): 
Srikumar, Ramasundaram
Jeya Parthasarathy, Narayanaperumal
Sheela Devi, Rathinasamy
Publication Title: 
Molecular and Cellular Biochemistry

Stress is one of the basic factors in the etiology of number of diseases. The present study was aimed to investigate the effect of Triphala (Terminalia chebula, Terminalia belerica and Emblica officinalis) on noise-stress induced alterations in the antioxidant status and on the cell-mediated immune response in Wistar strain male albino rats. Noise-stress employed in this study was 100 dB for 4 h/d/15 days and Triphala was used at a dose of 1 g/kg/b.w/48 days.

Author(s): 
Srikumar, Ramasundaram
Parthasarathy, Narayanaperumal Jeya
Manikandan, Sundaramagalingam
Narayanan, Govindarajulu Sathya
Sheeladevi, Rathinasamy
Publication Title: 
Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan

Stress is one of the basic factors in the etiology of number of diseases. Cold-stress occurs when the surrounding temperature drops below 18 degrees C, the body may not be able to warm itself, and hence serious cold-related illnesses, permanent tissue damage and death may results.

Author(s): 
Dhanalakshmi, Selvakumar
Devi, Rathinasamy Sheela
Srikumar, Ramasundaram
Manikandan, Sundaramahalingam
Thangaraj, Ramasundaram
Publication Title: 
Environmental Health Perspectives

It has been observed that susceptibility to many degenerative diseases increases concurrently with industrialization and rising living standards. Although epidemiologic studies suggest that specific environmental and dietary factors may be important, caloric intake alone (as reflected in body size) may account for much of the differential risk observed among diverse human populations.

Author(s): 
Frame, L. T.
Hart, R. W.
Leakey, J. E.
Publication Title: 
Annals of the New York Academy of Sciences

Hardly an aspect of aging is more important than an organism's ability to withstand stress or to resist both internally and externally imposed insults. We know that as organisms loose their ability to resist these insults, aged organisms suffer more than the young. Therefore, a prime strategy for an organism's survival has been the evolutionarily adapted defense systems that guard against insult. For better survivability, an organism's defense system must be maximized to its full effect through well-coordinated networks of diverse biologically responsive elements.

Author(s): 
Yu, B. P.
Chung, H. Y.
Publication Title: 
Biology Letters

The enzyme telomerase lengthens telomeres-protective structures containing repetitive DNA sequences at chromosome ends. Telomere shortening is associated with diseases of ageing in mammals. Chronic stress has been related to shorter immune-cell telomeres, but telomerase activity under stress may be low, permitting telomere loss, or high, partially attenuating it. We developed an experimental model to examine the impacts of extended unpredictable stress on telomerase activity in male rats.

Author(s): 
Beery, Annaliese K.
Lin, Jue
Biddle, Joshua S.
Francis, Darlene D.
Blackburn, Elizabeth H.
Epel, Elissa S.
Publication Title: 
Biology Letters

The enzyme telomerase lengthens telomeres-protective structures containing repetitive DNA sequences at chromosome ends. Telomere shortening is associated with diseases of ageing in mammals. Chronic stress has been related to shorter immune-cell telomeres, but telomerase activity under stress may be low, permitting telomere loss, or high, partially attenuating it. We developed an experimental model to examine the impacts of extended unpredictable stress on telomerase activity in male rats.

Author(s): 
Beery, Annaliese K.
Lin, Jue
Biddle, Joshua S.
Francis, Darlene D.
Blackburn, Elizabeth H.
Epel, Elissa S.
Publication Title: 
The World Journal of Biological Psychiatry: The Official Journal of the World Federation of Societies of Biological Psychiatry

Stress is commonly associated with a variety of psychiatric conditions, including major depression, and with chronic medical conditions, including diabetes and insulin resistance. Whether stress causes these conditions is uncertain, but plausible mechanisms exist by which such effects might occur. To the extent stress-induced hormonal alterations (e.g., chronically elevated cortisol levels and lowered dehydroepiandrosterone [DHEA] levels) contribute to psychiatric and medical disease states, manipulations that normalize these hormonal aberrations should prove therapeutic.

Author(s): 
Wolkowitz, O. M.
Epel, E. S.
Reus, V. I.
Publication Title: 
Biological Psychiatry

BACKGROUND: There has been recent interest in the possibility that epigenetic mechanisms might contribute to the transgenerational transmission of stress-induced vulnerability. Here, we focused on possible paternal transmission with the social defeat stress paradigm. METHODS: Adult male mice exposed to chronic social defeat stress or control nondefeated mice were bred with normal female mice, and their offspring were assessed behaviorally for depressive- and anxiety-like measures. Plasma levels of corticosterone and vascular endothelial growth factor were also assayed.

Author(s): 
Dietz, David M.
LaPlant, Quincey
Watts, Emily L.
Hodes, Georgia E.
Russo, Scott J.
Feng, Jian
Oosting, Ronald S.
Vialou, Vincent
Nestler, Eric J.
Publication Title: 
Neuroscience Letters

Plasma corticosterone has been correlated with the susceptibility to animal hypnosis in male rabbits. Subjects (Ss) were considered susceptible when mean hypnosis duration was above 30 sec or when initial duration (duration of trial 1) was greater than 0. A positive significant correlation was found between mean and initial duration. A significant difference was found between corticosterone levels in susceptible and unsusceptible Ss: higher values were associated with susceptible SS and with SS with initial duration greater than 0.

Author(s): 
Carli, G.
Farabollini, F.
di Prisco, C. L.

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