Coumarins

Publication Title: 
Chemical & Pharmaceutical Bulletin

Notopterol was identified as the analgesic component of Notopterygium incisum TING by using the acetic acid-induced writhing method. Notopterol also indicated an anti-inflammatory activity by its inhibitory effect in the vascular permeability test. The intensive prolongation of pentobarbital-induced hypnosis was possibly caused by its inhibitory effect on the drug metabolism in liver. Pharmacological differences between the analgesic components of N. incisum, Aralia cordata and Angelica pubescens were also discussed.

Author(s): 
Okuyama, E.
Nishimura, S.
Ohmori, S.
Ozaki, Y.
Satake, M.
Yamazaki, M.
Publication Title: 
Pharmacological reports: PR

BACKGROUND: In addition to recognized antimalarial effects, Artemisia annua L. (Qinghao) possesses anticancer properties. The underlying mechanisms of this activity are unknown. The aim of our experiments was to investigate the effects of distinct types of compounds isolated from A. annua on the immune-activated production of major mediators of angiogenesis playing a crucial role in growth of tumors and formation of metastasis. METHODS: Included in the study were the sesquiterpene lactones artemisinin and its biogenetic precursors arteannuin B and artemisinic acid.

Author(s): 
Zhu, Xiaoxin X.
Yang, Lan
Li, Yujie J.
Zhang, Dong
Chen, Ying
Kostecká, Petra
Kmoní?ková, Eva
Zídek, Zden?k
Publication Title: 
European journal of cancer prevention: the official journal of the European Cancer Prevention Organisation (ECP)

The essential oil, emulsion or paste of sandalwood (Santalum album L) has been used in India as an ayurvedic medicinal agent for the treatment of inflammatory and eruptive skin diseases. In this investigation, the chemopreventive effects of sandalwood oil (5% in acetone, w/v) on 7,12-dimethylbenz(a)anthracene-(DMBA)-initiated and 12-O-tetradecanoyl phorbol-13-acetate(TPA)-promoted skin papillomas, and TPA-induced ornithine decarboxylase (ODC) activity in CD1 mice were studied.

Author(s): 
Dwivedi, C.
Abu-Ghazaleh, A.
Publication Title: 
Archives of Dermatological Research

Alopecia is a dermatological disorder with psychosocial implications on patients with hair loss. Eclipta alba Hassk. is a well-known Ayurvedic herb with purported claims of hair growth promotion. In the reported work attempts were undertaken to evaluate petroleum ether and ethanol extract of E. alba Hassk. for their effect on promoting hair growth in albino rats. The extracts were incorporated into oleaginous cream (water in oil cream base) and applied topically on shaved denuded skin of albino rats.

Author(s): 
Roy, R. K.
Thakur, Mayank
Dixit, V. K.
Publication Title: 
International Immunopharmacology

Mesua ferrea L. (Nagkesar) is traditionally being used for antiseptic, anti-inflammatory, antiasthmatic and antiallergic activities. It is an ingredient of ayurvedic formulations like Brahma Rasayana and Chyavanprash which are being used to improve immunity. The present study was performed to evaluate immunomodulatory activity of mesuol isolated from M. ferrea seed oil in experimental animals.

Author(s): 
Chahar, Manoj Kumar
Sanjaya Kumar, D. S.
Lokesh, T.
Manohara, K. P.
Publication Title: 
The Journal of Nutrition

Ellagitannins (ETs) from pomegranate juice (PJ) are reported to have numerous biological properties, but their absorption and metabolism in humans are poorly understood. To investigate the pharmacokinetics of pomegranate ETs, 18 healthy volunteers were given 180 mL of PJ concentrate, and blood samples were obtained for 6 h afterwards. Twenty-four-hour urine collections were obtained on the day before (-1), the day of (0), and the day after (+1) the study.

Author(s): 
Seeram, Navindra P.
Henning, Susanne M.
Zhang, Yanjun
Suchard, Marc
Li, Zhaoping
Heber, David
Publication Title: 
Bioorganic & Medicinal Chemistry

Bioactivity-guided fractionation of Notopterygium forbesii has resulted in the isolation of one new coumarin glycoside and one new phenethyl vanillate, together with seventeen known compounds. The structures of these compounds were characterized by spectroscopic methods. These compounds were evaluated for their binding affinities to the opioid and dopamine receptors, and falcarindiol showed weak binding affinities to opioid receptors and moderate affinity for D1 receptor (K(i)=192+/-6 nM).

Author(s): 
Ma, Zhongze
Xu, Wei
Liu-Chen, Lee-Yuan
Lee, David Y. W.
Publication Title: 
Journal of Medicinal Food

Pomegranate juice (PJ), a rich source of polyphenols including ellagitannins, has attracted much attention due to its reported health benefits. This has resulted in the consumption of liquid and powder pomegranate extracts as alternatives to PJ. Therefore establishing the bioavailability of polyphenols from these extract preparations is necessary.

Author(s): 
Seeram, Navindra P.
Zhang, Yanjun
McKeever, Rodney
Henning, Susanne M.
Lee, Ru-po
Suchard, Marc A.
Li, Zhaoping
Chen, Steve
Thames, Gail
Zerlin, Alona
Nguyen, Martha
Wang, David
Dreher, Mark
Heber, David
Publication Title: 
Cancer Prevention Research (Philadelphia, Pa.)

The protein kinase Akt plays an important role in cell proliferation and survival in many cancers, including prostate cancer. Due to its kinase activity, it serves as a molecular conduit for inhibiting apoptosis and promoting angiogenesis in most cell types. In most of the prostate tumors, Akt signaling is constitutively activated due to the deletion or mutation of the tumor suppressor PTEN, which negatively regulates phosphatidylinositol 3-kinase through lipid phosphatase activity.

Author(s): 
Kumar, Raj
Srinivasan, Sowmyalakshmi
Koduru, Srinivas
Pahari, Pallab
Rohr, Jürgen
Kyprianou, Natasha
Damodaran, Chendil
Publication Title: 
The Journal of Organic Chemistry

A base-catalyzed condensation of phenyl acetate with acid chloride, followed by intramolecular cyclization and microwave-assisted cross-metathesis reaction, leads to the first total synthesis of psoralidin, a natural product with a broad range of biological activities, in a highly convergent and regioselective manner.

Author(s): 
Pahari, Pallab
Rohr, Jürgen

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