CREB-Binding Protein

Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

Longevity regulatory genes include the Forkhead transcription factor FOXO and the NAD-dependent histone deacetylase silent information regulator 2 (Sir2). Genetic studies demonstrate that Sir2 acts to extend lifespan in Caenorhabditis elegans upstream of DAF-16, a member of the FOXO family, in the insulin-like signaling pathway. However, the molecular mechanisms underlying the requirement of DAF-16 activity in Sir2-mediated longevity remain unknown. Here we show that reversible acetylation of Foxo1 (also known as FKHR), the mouse DAF-16 ortholog, modulates its transactivation function.

Daitoku, Hiroaki
Hatta, Mitsutoki
Matsuzaki, Hitomi
Aratani, Satoko
Ohshima, Takayuki
Miyagishi, Makoto
Nakajima, Toshihiro
Fukamizu, Akiyoshi
Publication Title: 
Statistics in Medicine

Epigenetics is the study of changes to the genome that can switch genes on or off and determine which proteins are transcribed without altering the DNA sequence. Recently, epigenetic changes have been linked to the development and progression of disease such as psychiatric disorders. High-throughput epigenetic experiments have enabled researchers to measure genome-wide epigenetic profiles and yield data consisting of intensity ratios of immunoprecipitation versus reference samples.

Wang, Xinlei
Zang, Miao
Xiao, Guanghua
Publication Title: 
Journal of Genetics and Genomics = Yi Chuan Xue Bao

The most remarkable feature of the nervous system is that the development and functions of the brain are largely reshaped by postnatal experiences, in joint with genetic landscapes. The nature vs. nurture argument reminds us that both genetic and epigenetic information is indispensable for the normal function of the brain. The epigenetic regulatory mechanisms in the central nervous system have been revealed over last a decade. Moreover, the mutations of epigenetic modulator genes have been shown to be implicated in neuropsychiatric disorders, such as autism spectrum disorders.

Lv, Jingwen
Xin, Yongjuan
Zhou, Wenhao
Qiu, Zilong
Publication Title: 
International Journal of Molecular Sciences

Rubinstein-Taybi syndrome (RSTS) is a rare condition with a prevalence of 1 in 125,000-720,000 births and characterized by clinical features that include facial, dental, and limb dysmorphology and growth retardation. Most cases of RSTS occur sporadically and are caused by de novo mutations. Cytogenetic or molecular abnormalities are detected in only 55% of RSTS cases. Previous genetic studies have yielded inconsistent results due to the variety of methods used for genetic analysis.

Yoo, Hee Jeong
Kim, Kyung
Kim, In Hyang
Rho, Seong-Hwan
Park, Jong-Eun
Lee, Ki Young
Kim, Soon Ae
Choi, Byung Yoon
Kim, Namshin
Publication Title: 

One of the exceptional properties of the brain is its ability to acquire new knowledge through learning and to store that information through memory. The epigenetic mechanisms linking changes in neuronal transcriptional programs to behavioral plasticity remain largely unknown. Here, we identify the epigenetic signature of the neuronal enhancers required for transcriptional regulation of synaptic plasticity genes during memory formation, linking this to Reelin signaling.

Telese, Francesca
Ma, Qi
Perez, Patricia Montilla
Notani, Dimple
Oh, Soohwan
Li, Wenbo
Comoletti, Davide
Ohgi, Kenneth A.
Taylor, Havilah
Rosenfeld, Michael G.
Publication Title: 

RATIONALE: The transcription factor cAMP responsive element-binding protein 1 (CREB1) has a complex influence on behavioural responses to drugs of abuse which varies depending on the brain region in which it is expressed. In response to drug exposure, CREB1 is phosphorylated in the striatum, a structure that is critically involved in reward-related learning. OBJECTIVE: The present study assessed the role of striatal CREB1 and its coactivator CREB-binding protein (CBP) in behavioural responses to psychostimulants.

Madsen, Heather B.
Navaratnarajah, Srigala
Farrugia, Jessica
Djouma, Elvan
Ehrlich, Michelle
Mantamadiotis, Theo
Van Deursen, Jan
Lawrence, Andrew J.
Publication Title: 
Arteriosclerosis, Thrombosis, and Vascular Biology

OBJECTIVE: C-Reactive protein (CRP), a cardiovascular risk marker, could also participate in atherosclerosis. Atherosclerotic plaques express CRP and interleukin (IL)-10, a major antiinflammatory cytokine. IL-10 deficiency results in increased lesion formation, whereas IL-10 delivery attenuates lesions. We tested the effect of CRP on lipopolysaccharide (LPS)-induced IL-10 secretion in human monocyte-derived macrophages (HMDMs).

Singh, Uma
Devaraj, Sridevi
Dasu, Mohan R.
Ciobanu, Dana
Reusch, Jane
Jialal, Ishwarlal
Publication Title: 
International Journal of Molecular Sciences

We investigated whether δ-opioid receptor (DOR)-induced neuroprotection involves the brain-derived neurotrophic factor (BDNF) pathway. We studied the effect of DOR activation on the expression of BDNF and other proteins in the cortex of C57BL/6 mice exposed to hypoxia (10% of oxygen) for 1-10 days.

Tian, Xuesong
Hua, Fei
Sandhu, Harleen K.
Chao, Dongman
Balboni, Gianfranco
Salvadori, Severo
He, Xiaozhou
Xia, Ying
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Tabebuia avellanedae Lorentz ex Griseb is a plant employed in tropical America folk medicine for the treatment of several diseases, including depressive disorders.

Freitas, Andiara E.
Machado, Daniele G.
Budni, Josiane
Neis, Vivian B.
Balen, Grasiela O.
Lopes, Mark W.
de Souza, Luiz F.
Veronezi, Patricia O.
Heller, Melina
Micke, Gustavo A.
Pizzolatti, Moacir G.
Dafre, Alcir L.
Leal, Rodrigo B.
Rodrigues, Ana Lúcia S.
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