Crohn Disease

Publication Title: 
Journal of Crohn's & Colitis

BACKGROUND AND AIMS: Inflammatory bowel diseases (IBDs) are heterogeneous disorders with complex aetiology. Quantitative genetic studies suggest that only a small proportion of the disease variance observed in IBD is accounted for by genetic variation, indicating a potential role for differential epigenetic regulation in disease aetiology. The aim of this study was to assess genome-wide DNA methylation changes specifically associated with ulcerative colitis (UC), Crohn's disease (CD) and IBD activity.

McDermott, Edel
Ryan, Elizabeth J.
Tosetto, Miriam
Gibson, David
Burrage, Joe
Keegan, Denise
Byrne, Kathryn
Crowe, Eimear
Sexton, Gillian
Malone, Kevin
Harris, R. Alan
Kellermayer, Richard
Mill, Jonathan
Cullen, Garret
Doherty, Glen A.
Mulcahy, Hugh
Murphy, Therese M.
Publication Title: 
Journal of Gastroenterology

BACKGROUND: Although psychiatric disturbances and personality features are possibly involved in inflammatory bowel disease, little attention has been given to the potential role of defense mechanisms in the formation, course, or prognosis of the disease. The purpose of the present study was to determine whether certain defense styles and ego mechanisms of defense are associated with inflammatory bowel disease, including both ulcerative colitis and Crohn's disease. METHODS: Seventy-six consecutive unselected outpatients participated in the study.

Hyphantis, Thomas N.
Triantafillidis, John K.
Pappa, Sofia
Mantas, Christos
Kaltsouda, Anna
Cherakakis, Peter
Alamanos, Yannis
Manousos, Orestis N.
Mavreas, Venetsanos G.
Publication Title: 
The American Journal of Clinical Hypnosis

Ulcerative colitis and Crohn's Disease can be cured if they are treated as autoimmune diseases with a special understanding of the personality conflicts in the patient. The author hypothesizes that all autoimmune diseases are characterized by a high normal amount of the aggressive instinctual drives and ambivalence about their realization. Each patient's personality causes the ambivalence to be somaticized into specific autoimmune bodies that aggressively are overproduced and then attack specific tissues.

Schafer, D. W.
Publication Title: 
Seminars in Gastrointestinal Disease

At present, the medical management of inflammatory bowel diseases (IBD) including Crohn's disease and ulcerative colitis, are focused on topical, locally active antiinflammatories and systemic immunosuppressives, which are thought to exert their targeted effects in the gastrointestinal mucosa. There is a paucity of controlled trials assessing the impact of mind, central nervous system (CNS), and neuromodulation on the overly active immune response in the intestinal mucosa.

Anton, P. A.
Publication Title: 
The International Journal of Clinical and Experimental Hypnosis

Fifteen patients with severe or very severe inflammatory bowel disease on corticosteroids but not responding to medication received 12 sessions of "gut-focused hypnotherapy" and were followed up for a mean duration of 5.4 years with disease severity being graded as remission, mild, moderate, severe, or very severe. Two patients (13.4%) failed to respond and required surgery. At follow-up for the remaining 13 patients, 4 (26.6%) were in complete remission, 8 (53.3%) had mild severity, and 1 (6.7%) was moderately severe. Quality of life became good or excellent in 12 (79.9%).

Miller, Vivien
Whorwell, Peter J.
Publication Title: 
The American Journal of Clinical Hypnosis

Idiopathic inflammatory bowel diseases (IBDs) significantly affect the quality of life of sufferers. Improved quality of life and patient symptom management may be achieved through integrating psychological/behavioral interventions with pharmacologic treatments. Here is our experience with hypnotherapy as an adjuvant management for an 18-year-old female with Crohn's Disease (CD) in remission (patient I) and a 24-year-old female with CD in active phase (patient II). The patients participated in 12 weekly one-hour sessions of hypnotherapy.

Emami, Mohammad Hassan
Gholamrezaei, Ali
Daneshgar, Houshang
Publication Title: 
Journal of developmental and behavioral pediatrics: JDBP
Shaoul, Ron
Sukhotnik, Igor
Mogilner, Jorge
Publication Title: 
Child and Adolescent Psychiatric Clinics of North America

This article reviews the etiology, clinical characteristics, and treatment of inflammatory bowel disease (IBD) and associated psychological sequelae in children and adolescents with this lifelong disease. Pediatric-onset IBD, consisting of Crohn's disease and ulcerative colitis, has significant medical morbidity and in many young persons is also associated with psychological and psychosocial challenges.

Szigethy, Eva
McLafferty, Laura
Goyal, Alka
Publication Title: 
Complementary Therapies in Nursing & Midwifery

A diagnosis of polyarthritis and later Chron's disease was initially treated by traditional treatments and medicines, which was later supported by aromatherapy and acupuncture, but the turning point to a full recovery followed from a visit to a naturopath and the commencement of an individual/personal diet regime. Over the months of the acute phase of the illness, a valuable insight was gained to the challenges of a physical disability and the difficulties of immobility, and the loss of independence.

Ballard, A. E.
Publication Title: 
Journal of Crohn's & Colitis

BACKGROUND AND AIM: Complementary and alternative medicines (CAM) are being used increasingly by patients with Crohn's disease (CD) and ulcerative colitis (UC). We aimed to assess the prevalence and usage of CAM in different geographical areas of Italy and possible predictors of their use. METHODS AND MATERIALS: A structured questionnaire, administered to outpatients, attending 8 general hospitals and 9 tertiary referral centres, was completed by 2011 patients (909 CD, 1087 UC and 15 indeterminate colitis). 583 patients lived in the North, 659 in Central Italy and 769 in the South.

Bertomoro, Perla
Renna, Sara
Cottone, Mario
Riegler, Gabriele
Bossa, Fabrizio
Giglio, Licio
Pastorelli, Luca
Papi, Claudio
Castiglione, Fabiana
Angelucci, Erika
Pica, Roberta
Di Paolo, Maria Carla
D'Incà, Renata


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