Cyclic AMP-Dependent Protein Kinases

Publication Title: 
Aging

In chronologically aging yeast, longevity can be extended by administering a caloric restriction (CR) diet or some small molecules. These life-extending interventions target the adaptable target of rapamycin (TOR) and cAMP/protein kinase A (cAMP/PKA) signaling pathways that are under the stringent control of calorie availability.

Author(s): 
Goldberg, Alexander A.
Richard, Vincent R.
Kyryakov, Pavlo
Bourque, Simon D.
Beach, Adam
Burstein, Michelle T.
Glebov, Anastasia
Koupaki, Olivia
Boukh-Viner, Tatiana
Gregg, Christopher
Juneau, Mylène
English, Ann M.
Thomas, David Y.
Titorenko, Vladimir I.
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

An extract of the plant Coleus forskohlii has been used for centuries in Ayurvedic medicine to treat various diseases such as hypothyroidism, heart disease, and respiratory disorders. Additionally, complex herbal mixtures containing this extract are gaining popularity in United States for their putative "fat-burning" properties. The active ingredient in C. forskohlii extract is the diterpene compound forskolin.

Author(s): 
Ding, Xunshan
Staudinger, Jeff L.
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

An extract of the plant Coleus forskohlii has been used for centuries in Ayurvedic medicine to treat various diseases such as hypothyroidism, heart disease, and respiratory disorders. Additionally, complex herbal mixtures containing this extract are gaining popularity in United States for their putative "fat-burning" properties. The active ingredient in C. forskohlii extract is the diterpene compound forskolin.

Author(s): 
Ding, Xunshan
Staudinger, Jeff L.
Publication Title: 
Alcohol (Fayetteville, N.Y.)

Andrographis paniculata (AP) is a traditional medicinal plant of Ayurveda. It grows widely in Asia and is prescribed in the treatment of liver diseases. Here we have investigated the beneficial role of 14-deoxyandrographolide (14-DAG), a bioactive diterpenoid from AP, against alcoholic steatosis in rats. 14-DAG was extracted from aerial parts (leaves and stems) of AP. Rats were fed with ethanol for 8 weeks. Animals were treated with 14-DAG during the last 4 weeks of ethanol treatment. In vitro studies were undertaken in a human hepatocellular liver carcinoma cell line culture.

Author(s): 
Mandal, Samir
Mukhopadhyay, Sibabrata
Bandhopadhyay, Sukdeb
Sen, Gargi
Biswas, Tuli
Publication Title: 
European Journal of Pharmacology

We recently found that genistein, a plant-derived natural compound, is a novel cAMP signaling agonist in pancreatic beta-cells. In the present study, we further show that exposure of clonal insulin secreting (INS-1E) cells to genistein for 48 h enhanced glucose-stimulated insulin secretion (GSIS), whereas insulin content was not altered, suggesting that genistein-enhanced GSIS is not due to a modulation of insulin synthesis. This genistein effect is protein tyrosine kinase- and K(ATP) channel-independent.

Author(s): 
Fu, Zhuo
Liu, Dongmin
Publication Title: 
Clinical Nutrition (Edinburgh, Scotland)

BACKGROUND & AIMS: Abscisic acid (ABA) is effective in preventing insulin resistance and obesity-related inflammation through a PPAR γ-dependent mechanism. The objective of this study was to assess the efficacy ABA in improving glucose homeostasis and suppress inflammation when administered in combination with rosiglitazone (Ros) and to determine whether PPAR γ activation by ABA is initiated via cAMP/protein kinase A (PKA) signaling. METHODS: Obese db/db mice were fed high-fat diets containing 0, 10, or 70 mg/kg Ros with and without racemic ABA (100 mg/kg) for 60 days.

Author(s): 
Guri, Amir J.
Hontecillas, Raquel
Bassaganya-Riera, Josep
Publication Title: 
Endocrinology

Genistein, a flavonoid in legumes and some herbal medicines, has various biological actions. However, studies on whether genistein has an effect on pancreatic beta-cell function are very limited. In the present study, we investigated the effect of genistein on beta-cell proliferation and cellular signaling related to this effect and further determined its antidiabetic potential in insulin-deficient diabetic mice. Genistein induced both INS1 and human islet beta-cell proliferation after 24 h of incubation, with 5 mum genistein inducing a maximal 27% increase.

Author(s): 
Fu, Zhuo
Zhang, Wen
Zhen, Wei
Lum, Hazel
Nadler, Jerry
Bassaganya-Riera, Josep
Jia, Zhenquan
Wang, Yanwen
Misra, Hara
Liu, Dongmin
Publication Title: 
PloS One

BACKGROUND: Abnormal regulation of the inflammatory response is an important component of diseases such as diabetes, Alzheimer's disease and multiple sclerosis (MS). Lipoic acid (LA) has been shown to have antioxidant and anti-inflammatory properties and is being pursued as a therapy for these diseases. We first reported that LA stimulates cAMP production via activation of G-protein coupled receptors and adenylyl cyclases. LA also suppressed NK cell activation and cytotoxicity.

Author(s): 
Salinthone, Sonemany
Yadav, Vijayshree
Schillace, Robynn V.
Bourdette, Dennis N.
Carr, Daniel W.
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

The breakdown of triglycerides, or lipolysis, is a tightly controlled process that regulates fat mobilization in accord with an animal's energy needs. It is well established that lipolysis is stimulated by hormones that signal energy demand and is suppressed by the antilipolytic hormone insulin. However, much still remains to be learned about regulation of lipolysis by intracellular signaling pathways in adipocytes.

Author(s): 
Yang, Ri-Yao
Yu, Lan
Graham, James L.
Hsu, Daniel K.
Lloyd, K. C. Kent
Havel, Peter J.
Liu, Fu-Tong
Publication Title: 
PloS One

Beneficial microbes and probiotic species, such as Lactobacillus reuteri, produce biologically active compounds that can modulate host mucosal immunity. Previously, immunomodulatory factors secreted by L. reuteri ATCC PTA 6475 were unknown. A combined metabolomics and bacterial genetics strategy was utilized to identify small compound(s) produced by L. reuteri that were TNF-inhibitory.

Author(s): 
Thomas, Carissa M.
Hong, Teresa
van Pijkeren, Jan Peter
Hemarajata, Peera
Trinh, Dan V.
Hu, Weidong
Britton, Robert A.
Kalkum, Markus
Versalovic, James

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