Cyclin E

Publication Title: 
Journal of Cellular Biochemistry

Curcumin, a polyphenolic compound isolated from Curcuma longa (Turmeric) is widely used in traditional Ayurvedic medicine. Its potential therapeutic effects on a variety of diseases have long been known. Though anti-tumour effects of curcumin have been reported earlier, its mode of action and telomerase inhibitory effects are not clearly determined in brain tumour cells. In the present study, we demonstrate that curcumin binds to cell surface membrane and infiltrates into cytoplasm to initiate apoptotic events.

Khaw, Aik Kia
Hande, M. Pradeepa
Kalthur, Guruprasad
Hande, M. Prakash
Publication Title: 
Molecular cancer research: MCR

Mesothelin (MSLN) is a cell surface glycoprotein that is overexpressed in human pancreatic cancer. Although its value as a tumor marker for diagnosis and prognosis and as a preferred target of immunointervention has been evaluated, there is little information on the growth advantage of MSLN on tumor cells.

Bharadwaj, Uddalak
Li, Min
Chen, Changyi
Yao, Qizhi
Publication Title: 
International Journal of Nanomedicine

Traditional Chinese medicine is gradually becoming a new source of anticancer drugs. One such example is wogonin, which is cytotoxic to various cancer cell lines in vitro. However, due to its low water solubility, wogonin is restricted to clinical administration. Recently, the application of drug-coated magnetic nanoparticles (MNPs) to increase water solubility of the drug and to enhance its chemotherapeutic efficiency has attracted much attention.

Wang, Lei
Zhang, Haijun
Chen, Baoan
Xia, Guohua
Wang, Shuai
Cheng, Jian
Shao, Zeye
Gao, Chong
Bao, Wen
Tian, Liang
Ren, Yanyan
Xu, Peipei
Cai, Xiaohui
Liu, Ran
Wang, Xuemei
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