Publication Title: 
Journal of Invertebrate Pathology

A consistent supply of healthy tarnished plant bug, Lygus lineolaris (Palisot de Beauvois) (Hemiptera: Miridae), is necessary for the development of novel management strategies targeting this pest. After being in culture for several years, a substantial portion of a tarnished plant bug colony was found to be infected with a Nosema (Microsporidia) species. Studies were subsequently undertaken to evaluate the impact of Nosema infection on tarnished plant bug productivity and to test the efficacy of fumagillin to treat this infection.

Musser, Fred R.
Knighten, Kathy S.
Self, Sarah R.
Publication Title: 
The Journal of Biological Chemistry
Davidson, B. E.
Blackburn, E. H.
Dopheide, T. A.
Publication Title: 
European Cells & Materials

Long bone and in particular tibia fractures frequently fail to heal. A disturbed revascularisation is supposed to be a major cause for impaired bone healing or the development of non-unions. We aim to establish an animal model, which reliably mimics the clinical situation. Human microvascular endothelial cells (HMEC-1) and primary human osteoblast like cells (POBs) were cultured with different angiogenesis-inhibitors (Fumagillin, SU5416, Artesunate and 3,5,4'-Trimethoxystilbene) released out of poly(D,L-Lactide) (PDLLA) coated k-wires and cell activity was determined.

Fassbender, M.
Strobel, C.
Rauhe, J. S.
Bergmann, C.
Schmidmaier, G.
Wildemann, B.
Publication Title: 
AIDS research and human retroviruses

HIV-1 drug resistance monitoring in resource-poor settings is crucial due to limited drug alternatives. Recent reports of the increased prevalence of CXCR4 usage in subtype C infections may have implications for CCR5 antagonists in therapy. We investigated the prevalence of drug resistance mutations and CXCR4 coreceptor utilization of viruses from HIV-1 subtype C-infected children. Fifty-one children with virological failure during highly active antiretroviral therapy (HAART) and 43 HAART-naive children were recruited.

Green, Taryn N.
Archary, Mohendran
Gordon, Michelle L.
Padayachi, Nagavelli
Lie, Yolanda
Anton, Elizabeth D.
Reeves, Jacqueline D.
Grobler, Anneke
Bobat, Raziya
Coovadia, Hoosen
Ndung'u, Thumbi
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