Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

Previous studies indicated that renal tubular epithelial cells from some long-lived avian species exhibit robust and/or unique protective mechanisms against oxidative stress relative to murine cells.

Ogburn, C. E.
Carlberg, K.
Ottinger, M. A.
Holmes, D. J.
Martin, G. M.
Austad, S. N.
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics
Indacochea-Redmond, N.
Witschi, H.
Plaa, G. L.
Publication Title: 
Molecular Pharmacology

S-Adenosylmethionine (SAMe) and its metabolite 5'-methylthioadenosine (MTA) inhibit mitogen-induced proliferative response in liver and colon cancer cells. SAMe and MTA are also proapoptotic in liver cancer cells by selectively inducing Bcl-x(S) expression. The aims of this work were to assess whether these agents are proapoptotic in colon cancer cells, and if so, to elucidate the molecular mechanisms. We found that both SAMe and MTA are proapoptotic in HT-29 and RKO cells in a dose- and time-dependent manner.

Li, Tony W. H.
Zhang, Qingsong
Oh, Pilsoo
Xia, Meng
Chen, Hui
Bemanian, Sean
Lastra, Natalie
Circ, Magda
Moyer, Mary Pat
Mato, José M.
Aw, Tak Yee
Lu, Shelly C.
Publication Title: 
Biological & Pharmaceutical Bulletin

Phosphatidylinositol 3-kinase (PI3K)/Akt inhibitors were isolated from the rhizome of Polygala tenuifolia WILLD (PT, Polygalaceae), which has been used in traditional Chinese medicine for inflammation, dementia, amnesia, neurasthenia and cancer, by activity-guided fractionation. For the assay of PI3K/Akt pathway, cytoprotective Tat-transduced CHME5 cells, which are the cytoprotective phenotype against lypopolysaccharide (LPS)/cycloheximide (CHX), were used.

Le, Thi Kim Van
Jeong, Jin Ju
Kim, Dong-Hyun
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