Cyclooxygenase 2

Publication Title: 
Journal of Pain and Symptom Management

The American College of Rheumatology (ACR) recently provided an update to the guidelines published in 1995 on the management of osteoarthritis (OA) of the knee and hip. Members of the Ad Hoc Committee on OA Guidelines followed an evidence-based medicine approach to revise the guidelines by reviewing an extensive literature search of the Cochrane and Medline databases and published abstracts, and discussing evidence with expert rheumatologists.

Author(s): 
Schnitzer, Thomas J.
American College of Rheumatology
Publication Title: 
Protein and Peptide Letters

Triphala is an Ayurvedic herbal formulation consisting of equal parts of three myrobalans: Terminalia chebula, Terminalia bellerica and Emblica officinalis. We recently reported that chebulagic acid (CA) isolated from Terminalia chebula is a potent COX-2/5-LOX dual inhibitor. In this study, compounds isolated from Terminalia bellerica were tested for inhibition against COX and 5-LOX. One of the fractionated compounds showed potent inhibition against COX enzymes with no inhibition against 5-LOX. It was identified as gallic acid (GA) by LC-MS, NMR and IR analyses.

Author(s): 
Reddy, Tamatam Chandramohan
Aparoy, Polamarasetty
Babu, Neela Kishore
Kumar, Kotha Anil
Kalangi, Suresh Kumar
Reddanna, Pallu
Publication Title: 
Medicinal Chemistry (Shariqah (United Arab Emirates))

Non-steroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase-2 (COX-2) specific inhibitors are anti-inflammatory agents that have also shown to be useful in anticancer therapy. The effects of chebulagic acid (CA), a benzopyran tannin from Terminalia chebula having COX-2/5-LOX dual inhibitory properties, on the sensitivity of doxorubicin (Dox) in human hepatocellular carcinoma cell line HepG2 were studied in the present investigation. CA increased the accumulation of Dox in a concentration dependant manner and also enhanced the cytotoxicity of Dox in HepG2 cells by 20 folds.

Author(s): 
Achari, Chandrani
Reddy, Gorla V.
Reddy, T. C. M.
Reddanna, Pallu
Publication Title: 
PloS One

Rheumatoid arthritis is a chronic degenerative autoimmune disease characterized by persistent inflammation of synovial membranes, which leads to cartilage destruction and bone erosion. To date, there are no effective therapies to slow the progress of this degenerative condition. Here, we evaluate the anti-arthritic effect of chebulanin, an abundant anti-inflammatory agent isolated from Terminalia chebula, in collagen induced arthritis in DBA/1 mice by intragastric administration.

Author(s): 
Zhao, Yinglan
Liu, Fang
Liu, Yao
Zhou, Dan
Dai, Qing
Liu, Songqing
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The fruit of the Terminalia chebula tree has been widely used for the treatment of various disorders. Its anti-diabetic, anti-mutagenic, anti-oxidant, anti-bacterial, anti-fungal, and anti-viral effects have been studied. Dental plaque bacteria (DPB) are intimately associated with gingivitis and periodontitis. In the quest for materials that will prove useful in the treatment and prevention of periodontal disease, we investigated the preventive effects of an ethanol extract of Terminalia chebula (EETC) on DPB-induced inflammation and bone resorption.

Author(s): 
Lee, Jongsung
Nho, Youn Hwa
Yun, Seok Kyun
Hwang, Young Sun
Publication Title: 
Molecular and Cellular Biology

The AU-rich elements (AREs) encoded within many mRNA 3' untranslated regions (3'UTRs) are targets for factors that control transcript longevity and translational efficiency. Hsp70, best known as a protein chaperone with well-defined peptide-refolding properties, is known to interact with ARE-like RNA substrates in vitro. Here, we show that cofactor-free preparations of Hsp70 form direct, high-affinity complexes with ARE substrates based on specific recognition of U-rich sequences by both the ATP- and peptide-binding domains.

Author(s): 
Kishor, Aparna
Tandukar, Bishal
Ly, Yann V.
Toth, Eric A.
Suarez, Yvelisse
Brewer, Gary
Wilson, Gerald M.
Publication Title: 
Psychotherapy and Psychosomatics
Author(s): 
Kovács, Z. A.
Puskás, L. G.
Juhász, A.
Rimanóczy, A.
Hackler, L.
Kátay, L.
Gali, Z.
Vetró, A.
Janka, Z.
Kálmán, J.
Publication Title: 
Acta Pharmacologica Sinica

AIM: To elucidate the anti-inflammatory potentials and underlying mechanisms of SM905, a novel artemisinin derivative, in lipopolysaccharide (LPS)-stimulated murine macrophage RAW 264.7 cells. METHODS: Nitric oxide (NO) generation, cytokine production, and the protein expression levels of inducible nitric-oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were examined using a Griess assay, an enzyme-linked immunosorbent assay (ELISA) and a Western blotting assay, respectively. The mRNA expression was measured using real-time PCR.

Author(s): 
Wang, Jun-Xia
Hou, Li-Fei
Yang, Yang
Tang, Wei
Li, Ying
Zuo, Jian-ping
Publication Title: 
International Journal of Molecular Sciences

Bladder cancer is the most common malignant tumor of the urinary tract and remains one of the major causes of cancer death worldwide. In this study, we investigated the effect and mechanism of Artesunate (ART), a traditional Chinese medicine, on inducing apoptosis of human bladder cancer cells. In vivo antitumor activity was investigated in bladder cancer in rat by subcutaneous injection of different concentration of ART.

Author(s): 
Zuo, Wei
Wang, Zhen-Zhong
Xue, Jun
Publication Title: 
Cancer Letters

Swertia chirata, is a bitter plant, used in the Indian system of medicine (Ayurveda) for various human ailments. Our laboratory was the first to report the chemopreventive effect of this plant. The antiproliferative and pro-apoptotic action of amarogentin rich fraction of S. chirata is now demonstrated on a mouse skin carcinogenesis model. Immunohistochemical localization revealed a reduction in proliferating and increase in apoptotic cells in skin lesion following treatment, also reflected in the expression of molecular markers--Cox-II and caspase-3 proteins.

Author(s): 
Saha, Prosenjit
Mandal, Suvra
Das, Ashes
Das, Sukta

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