Cyclosporine

Publication Title: 
Veterinary Dermatology

The efficacy of pharmacological interventions used to treat canine atopic dermatitis, excluding fatty acid supplementation and allergen-specific immunotherapy, was evaluated based on the systematic review of prospective clinical trials published between 1980 and 2002.

Author(s): 
Olivry, T.
Mueller, R. S.
International Task Force on Canine Atopic Dermatitis
Publication Title: 
Antiviral Research

Hot water extracts of four traditional herbs, Geum japonicum, Syzygium aromaticum, Terminalia chebula and Rhus javanica, which have been shown to have anti-herpes simplex virus (HSV) activity in vivo, were examined for anti-cytomegalovirus (CMV) activity in vitro and in vivo in this study. They inhibited replication of human CMV and murine CMV (MCMV) in vitro. These anti-CMV activities in vivo were examined in an MCMV infection model using immunosuppressed mice.

Author(s): 
Yukawa, T. A.
Kurokawa, M.
Sato, H.
Yoshida, Y.
Kageyama, S.
Hasegawa, T.
Namba, T.
Imakita, M.
Hozumi, T.
Shiraki, K.
Publication Title: 
Journal of Pharmaceutical and Biomedical Analysis

Spinosin, a major bioactive herbal ingredient isolated from Semen Ziziphi Spinosae, plays an important role in sedation and hypnosis. However, the pharmacokinetic behavior of spinosin in special sites has not been reported. Microdialysis (MD) technique, as a continuous, realtime monitoring sampling technique, is very suitable for the evaluation of the disposition of diverse drugs.

Author(s): 
Ma, Rong-Hua
Yang, Jie
Qi, Lian-Wen
Xin, Gui-Zhong
Wang, Chong-Zhi
Yuan, Chun-Su
Wen, Xiao-Dong
Li, Ping
Publication Title: 
The Journal of Antimicrobial Chemotherapy

BACKGROUND AND OBJECTIVES: The immunosuppressant cyclosporin A and a number of other cyclosporins have potent and selective antimalarial activity. Their exact mechanism of antimalarial action is unknown but the structure-activity relationships for malarial parasite inhibition and immunosuppression differ markedly. The 3'-keto derivative of cyclosporin D (valspodar) is particularly potent against the human malarial parasite Plasmodium falciparum in culture but causes negligible immunosuppression.

Author(s): 
Gavigan, C. S.
Shen, M.
Machado, S. G.
Bell, A.
Publication Title: 
Chemico-Biological Interactions

Many herbs and spices are known to modulate the immune system and have been shown to restore the immunity in immuno-compromised individuals. Spices generally used to increase the taste and flavor of food also has the history of usage as an ayurvedic medicine. Therefore to explore the health modulating effects of Cuminum cyminum and to identify the active compound, immunomodulatory properties were evaluated using flowcytometry and ELISA in normal and immune-suppressed animals. C. cyminum and compound 1 stimulated the T cells and Th1 cytokines expression in normal animals.

Author(s): 
Chauhan, Prashant Singh
Satti, Naresh Kumar
Suri, Krishan Avtar
Amina, Musarat
Bani, Sarang
Publication Title: 
European Journal of Clinical Pharmacology

PURPOSE: P-glycoprotein limits the tissue penetration of many antiretroviral drugs. The aim of our study was to characterize the effects of the P-glycoprotein substrate cyclosporin A on T cell P-glycoprotein activity in human immunodeficiency virus-infected participants in the AIDS Clinical Trials Group study A5138. METHODS: We studied P-glycoprotein activity on CD4 and CD8 T cells in 16 participants randomized to receive oral cyclosporin A (n=9) or not (n=7) during initiation antiretroviral therapy (ART) that did not include protease or non-nucleoside reverse transcriptase inhibitors.

Author(s): 
Hulgan, Todd
Donahue, John P.
Smeaton, Laura
Pu, Minya
Wang, Hongying
Lederman, Michael M.
Smith, Kimberly
Valdez, Hernan
Pilcher, Christopher
Haas, David W.
AIDS Clinical Trials Group Study A5138 Team
Publication Title: 
Der Ophthalmologe: Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft

Recent epidemiologic studies quote a prevalence of 5,2% to 63% for dry eye depending on definition. Many risk factors have been identified, among other things the female gender. Dry eye interferes significantly with quality of live. Measurement of the change in temperature and humidity during blinking turned out to be a reliable diagnostic tool. Videokeratoscopy explains well-known visual impairments related to dry eye and, along with lipid film interferometry, provides insight into tear film dynamics. The importance of tear film proteins is underestimated.

Author(s): 
Schirra, F.
Ruprecht, K. W.
Publication Title: 
World journal of gastroenterology: WJG

Ulcerative colitis (UC) is an inflammatory destructive disease of the large intestine occurred usually in the rectum and lower part of the colon as well as the entire colon. Drug therapy is not the only choice for UC treatment and medical management should be as a comprehensive whole. Azulfidine, Asacol, Pentasa, Dipentum, and Rowasa all contain 5-aminosalicylic acid (5-ASA), which is the topical anti-inflammatory ingredient. Pentasa is more commonly used in treating Crohn's ileitis because Pentasa capsules release more 5-ASA into the small intestine than Asacol tablets.

Author(s): 
Xu, Chang-Tai
Meng, Shu-Yong
Pan, Bo-Rong
Publication Title: 
Revista Iberoamericana De Micología

Cordyceps sinensis (Berk.) Sacc. is an ascomycete fungus known in China since antiquity, which is still being used today. A summary, showing relevant papers about this fungus, regarding habitat, history, marketing, consumption, nomenclature, pharmacological composition, culture and medical use, is presented.

Author(s): 
Illana Esteban, Carlos
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