Cytomegalovirus Infections

Publication Title: 
Antiviral Research

Hot water extracts of four traditional herbs, Geum japonicum, Syzygium aromaticum, Terminalia chebula and Rhus javanica, which have been shown to have anti-herpes simplex virus (HSV) activity in vivo, were examined for anti-cytomegalovirus (CMV) activity in vitro and in vivo in this study. They inhibited replication of human CMV and murine CMV (MCMV) in vitro. These anti-CMV activities in vivo were examined in an MCMV infection model using immunosuppressed mice.

Author(s): 
Yukawa, T. A.
Kurokawa, M.
Sato, H.
Yoshida, Y.
Kageyama, S.
Hasegawa, T.
Namba, T.
Imakita, M.
Hozumi, T.
Shiraki, K.
Publication Title: 
Nihon Rinsho. Japanese Journal of Clinical Medicine

Medicinal herbs, Geum japonicum, Syzygium aromaticum, Terminalia chebula, and Rhus javanica, with anti-herpes simplex virus therapeutic activity, inhibited replication of human cytomegalovirus(CMV) and murine CMV(MCMV) in vitro. These anti-CMV activities were examined in an MCMV infection model using immunosuppressed mice. Geum japonicum, Syzygium aromaticum, and Terminalia chebula significantly suppressed MCMV yields in lungs of treated mice compared with water treatment.

Author(s): 
Shiraki, K.
Yukawa, T.
Kurokawa, M.
Kageyama, S.
Publication Title: 
Journal of Immunology (Baltimore, Md.: 1950)

Effector memory T cells are effective in controlling acute infections, but central memory T cells play a key role in long-lasting protection against viruses and tumors. In vivo/in vitro challenge by Ag commonly supports the generation of effector memory T cells with limited longevity. To our knowledge, this study demonstrates for the first time in the human system and under rechallenge conditions that targeting IL-2R by partial mammalian target of rapamycin inhibition or blocking IL-2R?

Author(s): 
Schmueck, Michael
Fischer, Annika M.
Hammoud, Ben
Brestrich, Gordon
Fuehrer, Henrike
Luu, Si-Hong
Mueller, Karin
Babel, Nina
Volk, Hans-Dieter
Reinke, Petra
Publication Title: 
Experimental Gerontology

Telomere length and telomerase activity have received increased attention as markers of cellular aging, but the determinants of inter-individual variation in these markers are incompletely understood. Cytomegalovirus (CMV) infection may be particularly important for telomere and telomerase dynamics due to its dramatic impact on peripheral blood lymphocyte composition, i.e., increasing the number and proportions of highly differentiated T cells that are characterized by shorter telomere length (TL) and lowered telomerase activity (TA).

Author(s): 
Dowd, Jennifer B.
Bosch, Jos A.
Steptoe, Andrew
Blackburn, Elizabeth H.
Lin, Jue
Rees-Clayton, Erin
Aiello, Allison E.
Publication Title: 
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America

This is the first report of treatment of cytomegalovirus infection with artesunate, for a stem cell transplant recipient with a newly identified foscarnet-resistant and ganciclovir-resistant DNA polymerase L776M mutation. Artesunate treatment resulted in a 1.7-2.1-log reduction in viral load by treatment day 7, with a viral half-life of 0.9-1.9 days, indicating a highly effective block in viral replication.

Author(s): 
Shapira, Michael Y.
Resnick, Igor B.
Chou, Sunwen
Neumann, Avidan U.
Lurain, Nell S.
Stamminger, Thomas
Caplan, Orit
Saleh, Niveen
Efferth, Thomas
Marschall, Manfred
Wolf, Dana G.
Publication Title: 
PloS One

BACKGROUND: Artesunate, an artemisinin-derived monomer, was reported to inhibit Cytomegalovirus (CMV) replication. We aimed to compare the in-vitro anti-CMV activity of several artemisinin-derived monomers and newly synthesized artemisinin dimers. METHODS: Four artemisinin monomers and two novel artemisinin-derived dimers were tested for anti-CMV activity in human fibroblasts infected with luciferase-tagged highly-passaged laboratory adapted strain (Towne), and a clinical CMV isolate. Compounds were evaluated for CMV inhibition and cytotoxicity.

Author(s): 
Arav-Boger, Ravit
He, Ran
Chiou, Chuang-Jiun
Liu, Jianyong
Woodard, Lauren
Rosenthal, Andrew
Jones-Brando, Lorraine
Forman, Michael
Posner, Gary
Publication Title: 
Antiviral Research

The anti-malaria drug artesunate has been shown to be an effective inhibitor of cytomegalovirus (CMV) in vitro, in an experimental animal model, and in a recent single-case clinical use. In this first case-series of 6 stem cell transplant recipients who received preemptive artesunate treatment for CMV infection, we have examined the viral kinetics following institution of artesunate, and employed first-phase viral kinetics studies to calculate its antiviral effectiveness.

Author(s): 
Wolf, Dana G.
Shimoni, Avichai
Resnick, Igor B.
Stamminger, Thomas
Neumann, Avidan U.
Chou, Sunwen
Efferth, Thomas
Caplan, Orit
Rose, Jessica
Nagler, Arnon
Marschall, Manfred
Publication Title: 
Bioorganic & Medicinal Chemistry

We recently reported the anti-cancer and anti-cytomegalovirus (CMV) activity of artemisinin-derived trioxane diphenylphosphate dimer 838. To probe the relationship between chemical structure and anti-CMV and anti-cancer activities, we now report synthesis and evaluation of a series of eight new dimer phosphate ester analogs of 838. This series of novel molecules was screened against human foreskin fibroblasts (HFFs) infected with CMV and against the human Jurkat T cell acute lymphoblastic leukemia cell line.

Author(s): 
Mott, Bryan T.
He, Ran
Chen, Xiaochun
Fox, Jennifer M.
Civin, Curt I.
Arav-Boger, Ravit
Posner, Gary H.
Publication Title: 
Journal of Clinical Virology: The Official Publication of the Pan American Society for Clinical Virology

BACKGROUND: Additional drugs are needed for the treatment of cytomegalovirus (CMV) infection. Artesunate is an antimalarial drug that has activity against CMV in vitro and in a rodent model. Only a small number of case reports are available describing the clinical effects of artesunate on CMV infection, and these yielded inconsistent results. OBJECTIVE: To evaluate the effect of artesunate on CMV infection, using blood samples collected from children who participated in malaria treatment trials.

Author(s): 
Gantt, Soren
Huang, Meei-Li
Magaret, Amalia
Bunts, Lisa
Selke, Stacy
Wald, Anna
Rosenthal, Philip J.
Dorsey, Grant
Casper, Corey
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