Dementia, Vascular

Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: Dementia is a widespread condition characterized by acquired global impairment of intellect, memory and personality, but with no impairment of consciousness. There is no definitive medical or surgical treatment for vascular dementia. Acupuncture is an ancient Chinese method which has been used for both the prevention and treatment of diseases for over three thousand years. Preliminary searches revealed more than 105 studies of acupuncture for treating vascular dementia. Benefit was reported in up to 70-91% of the treatment group.

Peng, W. N.
Zhao, H.
Liu, Z. S.
Wang, S.
Publication Title: 

OBJECTIVE: To examine the relative risk and population attributable risk (PAR) of death with dementia of varying type and severity and other risk factors in a population of exceptional longevity. METHODS: Deaths were monitored over 5 years using vital statistics records and newspaper obituaries in 355 individuals with prevalent dementia and 4,328 without in Cache County, UT. Mean age was 83.3 (SD 7.0) years with dementia and 73.7 (SD 6.8) years without. History of coronary artery disease, hypertension, diabetes, and other life-shortening illness was ascertained from interviews.

Tschanz, J. T.
Corcoran, C.
Skoog, I.
Khachaturian, A. S.
Herrick, J.
Hayden, K. M.
Welsh-Bohmer, K. A.
Calvert, T.
Norton, M. C.
Zandi, P.
Breitner, J. C. S.
Cache County Study Group
Publication Title: 
Journal of the Neurological Sciences

The burden of cognitive disorders is likely to increase over the coming years due to both increased longevity and altered risk factor patterns, arising from changes in lifestyle, healthcare and society. Vascular dementia with its underlying heterogeneous pathology, is a challenge for clinicians, and is frequently further aggravated by overlap with other neurodegenerative processes. Current Alzheimer's disease drugs have had limited clinical efficacy in treating vascular dementia and none have been approved by major regulatory authorities specifically for this disease.

Skoog, Ingmar
Korczyn, Amos D.
Guekht, Alla
Publication Title: 
Journal of the Neurological Sciences

Alzheimer's disease (AD) is a debilitating illness with no known cure. Nowadays accumulating evidence suggested that the vascular endothelium and chronic hypoperfusion may play important role in pathobiology of AD. The vascular endothelium which regulates the passage of macromolecules and circulating cells from blood to tissue, is a major target of oxidative stress, playing a critical role in the pathophysiology of vascular diseases.

Leszek, Jerzy
Sochocka, Marta
G?siorowski, Kazimierz
Publication Title: 
Journal of Psychopharmacology (Oxford, England)

The British Association for Psychopharmacology (BAP) coordinated a meeting of experts to review the evidence on the drug treatment for dementia. The level of evidence (types) was rated using a standard system: Types 1a and 1b (evidence from meta-analysis of randomised controlled trials or at least one controlled trial respectively); types 2a and 2b (one well-designed study or one other type of quasi experimental study respectively); type 3 (non-experimental descriptive studies); and type 4 (expert opinion).

Burns, Alistair
O'Brien, John
BAP Dementia Consensus group
Auriacombe, Sophie
Ballard, Clive
Broich, Karl
Bullock, Roger
Feldman, Howard
Ford, Gary
Knapp, Martin
McCaddon, Andrew
Iliffe, Steve
Jacova, Claudia
Jones, Roy
Lennon, Sean
McKeith, Ian
Orgogozo, Jean-Marc
Purandare, Nitin
Richardson, Mervyn
Ritchie, Craig
Thomas, Alan
Warner, James
Wilcock, Gordon
Wilkinson, David
British Association for Psychopharmacology
Publication Title: 
Psychogeriatrics: The Official Journal of the Japanese Psychogeriatric Society

OBJECTIVE: Recently, the importance of non-pharmacological therapies for dementia has come to the fore. In the present study, we examined the curative effects of aromatherapy in dementia in 28 elderly people, 17 of whom had Alzheimer's disease (AD). METHODS: After a control period of 28 days, aromatherapy was performed over the following 28 days, with a wash out period of another 28 days. Aromatherapy consisted of the use of rosemary and lemon essential oils in the morning, and lavender and orange in the evening.

Jimbo, Daiki
Kimura, Yuki
Taniguchi, Miyako
Inoue, Masashi
Urakami, Katsuya
Publication Title: 
The American Journal of Psychiatry

OBJECTIVE: The authors examined predictors of mortality in individuals age 50 or older with or without cognitive impairment in a 12-year prospective naturalistic study of subcortical ischemic vascular disease focusing on symptoms of depressed mood, apathy, anhedonia, or anergia. METHOD: A total of 498 participants were recruited from the community and from memory clinics into a multicenter longitudinal study of subcortical ischemic vascular disease. For baseline cognitive status, 36% of participants were assessed as cognitively intact, 31% as cognitively impaired, and 33% as demented.

Lavretsky, Helen
Zheng, Ling
Weiner, Michael W.
Mungas, Dan
Reed, Bruce
Kramer, Joel H.
Jagust, William
Chui, Helena
Mack, Wendy J.
Publication Title: 
Biological & Pharmaceutical Bulletin

Breviscapine, a traditional Chinese medicine, is extensively used in clinic to treat cardiovascular diseases and cerebrovascular injury. In this study, we demonstrated the effects of breviscapine on vascular dementia (VD) rats, which were mimicked by permanent occlusion of bilateral common carotid arteries.

Xiong, Zhe
Liu, Chao
Wang, Fang
Li, Cailian
Wang, Wei
Wang, Jianzhi
Chen, Jianguo
Publication Title: 
Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences

OBJECTIVE: To explore the effect of Naoxintong capsules on learning and dysmnesia and calcitonin gene-related peptide (CGRP) about vascular dementia (VD) in rats. METHODS: The model of vascular dementia rats were built by middle cerebral artery occlusion (MCAO), and then the rats were randomly divided into a Naoxintong group (that was traditional Chinese medicine group,TCM group), a Western medicine group, a model group, a sham operation group, and a normal group.

Liu, Shi-mei
Su, Nan-xiang
He, Ming-da
Wang, Zhe
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

BACKGROUND: There are obvious changes in neuropeptides from plasma and cerebrospinal fluid in patients with vascular dementia (VaD), and regulating the levels of neuropeptides is a key for prevention and treatment of VaD. OBJECTIVE: To observe the clinical efficacy of moxibustion at head-points in treatment of vascular dementia (VaD), and assess its effects on memory-related neuropeptides.

Wang, Pin
Yang, Jun
Liu, Gang
Chen, Hao
Yang, Fan


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