Dengue

Publication Title: 
Ecotoxicology and Environmental Safety

Aedes aegypti Linn is one of the most important mosquito species. The vectors are responsible for causing deadly diseases like dengue and dengue hemorrhagic fever. Several chemical pesticides used to control these dengue vectors caused severe toxic significances on human health and other non-target beneficial insects. Therefore the current investigation has been made to access the bio-efficacy of the crude seed extracts of T. chebula against the dengue vector Ae. aegypti. The GC-MS analysis of crude seed extracts of T.

Author(s): 
Thanigaivel, Annamalai
Vasantha-Srinivasan, Prabhakaran
Senthil-Nathan, Sengottayan
Edwin, Edward-Sam
Ponsankar, Athirstam
Chellappandian, Muthiah
Selin-Rani, Selvaraj
Lija-Escaline, Jalasteen
Kalaivani, Kandaswamy
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

Dengue virus (DENV) is considered to be the most important arthropod-borne viral disease and causes more than 100 million human infections annually. To further characterize primary DENV infection in vivo, rhesus macaques were infected with DENV-1, DENV-2, DENV-3, or DENV-4 and clinical parameters, as well as specificity and longevity of serologic responses, were assessed. Overt clinical symptoms were not present after infection.

Author(s): 
Hickey, Andrew C.
Koster, Jacob A.
Thalmann, Claudia M.
Hardcastle, Kathy
Tio, Phaik-Hooi
Cardosa, Mary J.
Bossart, Katharine N.
Publication Title: 
Journal of Medical Entomology

Male reproductive success is dependent on insemination success and reproductive output. During mating, male mosquitoes transfer not just sperm, but also seminal fluid proteins that may have profound effects on mated female biology and behavior. In this study, we investigated the role of male body size and mating history on semen depletion, female longevity, and reproductive success in Aedes aegypti L. Small and large males were mated in rapid succession with up to five females. Our results indicate that large males had greater mating capacity than small males.

Author(s): 
Helinski, Michelle E. H.
Harrington, Laura C.
Publication Title: 
Human Vaccines & Immunotherapeutics

Dengue, endemic in Puerto Rico, is a major public health problem. Vaccines are thought the best means to prevent dengue because vector control alone has been largely ineffective. We implemented qualitative studies in 2006 and 2010 to determine the acceptability of conducting placebo-controlled dengue vaccine efficacy trials in Puerto Rican children. Key informant interviews and focus groups with parents and children were conducted in municipalities with high dengue incidence.

Author(s): 
PÈrez-Guerra, Carmen L.
RodrÌguez-Acosta, Rosa L.
Soto-GÛmez, Eunice
Zielinski-Gutierrez, Emily
PeÒa-Orellana, Marisol
Santiago, Luis M.
Rivera, Reinaldo
Cruz, R. Rhode
RamÌrez, Viani
Tomashek, Kay M.
Dayan, Gustavo
Publication Title: 
Epidemiology and Infection

A suspected dengue fever outbreak occurred in 2010 at a solitary construction site in Shenzhen city, China. To investigate this epidemic, we used serological, molecular biological, and bioinformatics techniques. Of nine serum samples from suspected patients, we detected seven positive for dengue virus (DENV) antibodies, eight for DENV-1 RNA, and three containing live viruses. The isolated virus, SZ1029 strain, was sequenced and confirmed as DENV-1, showing the highest E-gene homology to D1/Malaysia/36000/05 and SG(EHI)DED142808 strains recently reported in Southeast Asia.

Author(s): 
Yang, F.
Guo, G. Z.
Chen, J. Q.
Ma, H. W.
Liu, T.
Huang, D. N.
Yao, C. H.
Zhang, R. L.
Xue, C. F.
Zhang, L.
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