Publication Title: 
PloS One

Bioactive bone substitute materials are a valuable alternative to autologous bone transplantations in the repair of skeletal defects. However, clinical studies have reported varying success rates for many commonly used biomaterials. While osteoblasts have traditionally been regarded as key players mediating osseointegration, increasing evidence suggests that bone-resorbing osteoclasts are of crucial importance for the longevity of applied biomaterials.

Keller, Johannes
Brink, Silja
Busse, Bjˆrn
Schilling, Arndt F.
Schinke, Thorsten
Amling, Michael
Lange, Tobias
Publication Title: 
Journal of Dental Research

Odontoblasts are dentin-secreting cells that survive for the whole life of a healthy tooth. Once teeth are completely erupted, odontoblasts transform into a mature stage that allows for their functional conservation for decades, while maintaining the capacity for secondary and reactionary dentin secretion. Odontoblasts are also critically involved in the transmission of sensory stimuli from the dentin-pulp complex and in the cellular defense against pathogens. Their longevity is sustained by an elaborate autophagic-lysosomal system that ensures organelle and protein renewal.

Couve, E.
Osorio, R.
Schmachtenberg, O.
Publication Title: 
Biological & Pharmaceutical Bulletin

Honokiol, a neolignan, is a physiologically active component of kouboku (Magnolia obovata), a herb used in traditional Chinese medicine. This study investigated the effects of honokiol on the differentiation and function of osteoclasts induced by receptor activator of nuclear factor-kappaB ligand (RANKL). Honokiol markedly inhibited RANKL-induced tartrate-resistant acid phosphatase (TRAP) activity and the formation of TRAP-positive multinucleated cells in both bone marrow-derived monocytes and RAW264 cells.

Hasegawa, Shin-Ichi
Yonezawa, Takayuki
Ahn, Jae-Yong
Cha, Byung-Yoon
Teruya, Toshiaki
Takami, Masamichi
Yagasaki, Kazumi
Nagai, Kazuo
Woo, Je-Tae
Publication Title: 
Journal of Dentistry

OBJECTIVES: A product comparison study to compare the short term clinical efficacy of a strontium acetate/silica toothpaste with an arginine/calcium carbonate paste for pain reduction in dentine hypersensitivity. METHODS: The study was examiner blind of two arm parallel design. Eighty healthy adult subjects from general dental practice with ≥2 sensitive teeth but otherwise good oral health, were enrolled and randomised to 1 of 2 toothpaste treatments, schedule provided by the sponsor. Almost equal numbers received each treatment.

West, N.
Newcombe, R. G.
Hughes, N.
Mason, S.
Maggio, B.
Sufi, F.
Claydon, N.
Publication Title: 
Journal of Dentistry

OBJECTIVE: Evaluate the efficacy of 0.8% arginine, potassium nitrate and sodium fluoride mouthwashes on dentine hypersensitivity reduction.

Elias Boneta, Augusto R.
Galán Salás, Rafael M.
Mateo, Luis R.
Stewart, Bernal
Mello, Sarita
Arvanitidou, Lia S.
Panagakos, Foti
DeVizio, William
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