Deoxycytidine

Publication Title: 
Neurobiology of Aging

Epigenetic dysregulation of gene expression is thought to be critically involved in the pathophysiology of Alzheimer's disease (AD). Recent studies indicate that DNA methylation and DNA hydroxymethylation are 2 important epigenetic mechanisms that regulate gene expression in the aging brain. However, very little is known about the levels of markers of DNA methylation and hydroxymethylation in the brains of patients with AD, the cell-type specificity of putative AD-related alterations in these markers, as well as the link between epigenetic alterations and the gross pathology of AD.

Author(s): 
Chouliaras, Leonidas
Mastroeni, Diego
Delvaux, Elaine
Grover, Andrew
Kenis, Gunter
Hof, Patrick R.
Steinbusch, Harry W. M.
Coleman, Paul D.
Rutten, Bart P. F.
van den Hove, Daniel L. A.
Publication Title: 
Experimental Neurology

A hexanucleotide repeat expansion residing within the C9ORF72 gene represents the most common known cause of amyotrophic lateral sclerosis (ALS) and places the disease among a growing family of repeat expansion disorders. The presence of RNA foci, repeat-associated translation products, and sequestration of RNA binding proteins suggests that toxic RNA gain-of-function contributes to pathology while C9ORF72 haploinsufficiency may be an additional pathological factor.

Author(s): 
Zeier, Zane
Esanov, Rustam
Belle, Kinsley C.
Volmar, Claude-Henry
Johnstone, Andrea L.
Halley, Paul
DeRosa, Brooke A.
Khoury, Nathalie
van Blitterswijk, Marka
Rademakers, Rosa
Albert, Jeffrey
Brothers, Shaun P.
Wuu, Joanne
Dykxhoorn, Derek M.
Benatar, Michael
Wahlestedt, Claes
Publication Title: 
AIDS patient care and STDs

In 2010, the iPrEx study demonstrated efficacy of daily emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) pre-exposure prophylaxis (PrEP) in reducing HIV acquisition among men who have sex with men. Adherence to study product was critical for PrEP efficacy, and varied considerably, with FTC/TDF detection rates highest in the United States.

Author(s): 
Gilmore, Hailey J.
Liu, Albert
Koester, Kimberly Ann
Amico, K. Rivet
McMahan, Vanessa
Goicochea, Pedro
Vargas, Lorena
Lubensky, David
Buchbinder, Susan
Grant, Robert
Publication Title: 
PloS One

Pancreatic cancer (PaCa) is one of the most lethal cancers, with an estimated 5-year survival of <5% even when patients are given the best treatment available. In addition, these treatments are often toxic and expensive, thus new agents which are safe, affordable and effective are urgently needed. We describe here the results of our study with acetyl-11-keto-β-boswellic acid (AKBA), an agent obtained from an Ayurvedic medicine, gum resin of Boswellia serrata. Whether AKBA has an activity against human PaCa, was examined in in vitro models and in an orthotopic nude mouse model of PaCa.

Author(s): 
Park, Byoungduck
Prasad, Sahdeo
Yadav, Vivek
Sung, Bokyung
Aggarwal, Bharat B.
Publication Title: 
PloS One

Pancreatic cancer (PaCa) is one of the most lethal cancers, with an estimated 5-year survival of <5% even when patients are given the best treatment available. In addition, these treatments are often toxic and expensive, thus new agents which are safe, affordable and effective are urgently needed. We describe here the results of our study with acetyl-11-keto-β-boswellic acid (AKBA), an agent obtained from an Ayurvedic medicine, gum resin of Boswellia serrata. Whether AKBA has an activity against human PaCa, was examined in in vitro models and in an orthotopic nude mouse model of PaCa.

Author(s): 
Park, Byoungduck
Prasad, Sahdeo
Yadav, Vivek
Sung, Bokyung
Aggarwal, Bharat B.
Publication Title: 
Anticancer Research

PHY906 is a Chinese medicine formula with claims for the treatment of severe gastrointestinal distress. PHY906 enhanced the therapeutic index of various chemotherapeutic agents in human hepatocellular carcinoma xenografts. Accordingly, here a phase I/II clinical study was conducted with the combination of capecitabine in patients with advanced, unresectable hepatocellular carcinoma. More than 60% of patients had either stable disease or better after two treatment cycles. Median overall survival was 9.2 months.

Author(s): 
Yen, Yun
So, Samuel
Rose, Michal
Saif, M. Wasif
Chu, Edward
Liu, Shwu-Huey
Foo, Angeline
Jiang, Zaoli
Su, Tahmun
Cheng, Yung-Chi
Publication Title: 
Pancreas

OBJECTIVES: The flavonoid quercetin holds promise as an antitumor agent in several preclinical animal models. However, the efficacy of oral administration of quercetin in a pancreatic cancer mouse model is unknown. METHODS: The antiproliferative effects of quercetin alone or in combination with gemcitabine were tested in 2 human pancreatic cancer cell lines using cell count and MTT assays. Apoptosis was evaluated by flow cytometry. Tumor growth in vivo was investigated in an orthotopic pancreatic cancer animal model using bioluminescence. Quercetin was administered orally in the diet.

Author(s): 
Angst, Eliane
Park, Jenny L.
Moro, Aune
Lu, Qing-Yi
Lu, Xuyang
Li, Gang
King, Jonathan
Chen, Monica
Reber, Howard A.
Go, Vay Liang W.
Eibl, Guido
Hines, Oscar J.
Publication Title: 
Cancer Research

Chemoresistance due to heterogeneity of the tumor microenvironment (TME) hampers the long-term efficacy of first-line therapies for lung cancer. Current combination therapies for lung cancer provide only modest improvement in survival, implicating necessity for novel approaches that suppress malignant growth and stimulate long-term antitumor immunity. Oxidative stress in the TME promotes immunosuppression by tumor-infiltrating myeloid-derived suppressor cells (MDSC), which inhibit host protective antitumor immunity.

Author(s): 
Sawant, Anandi
Schafer, Cara C.
Jin, Tong Huan
Zmijewski, Jaroslaw
Tse, Hubert M.
Roth, Justin
Sun, Zhihuan
Siegal, Gene P.
Thannickal, Victor J.
Grant, Stefan C.
Ponnazhagan, Selvarangan
Deshane, Jessy S.
Publication Title: 
International Journal of Cancer. Journal International Du Cancer

Agents that can potentiate the efficacy of standard chemotherapy against pancreatic cancer are of great interest. Because of their low cost and safety, patients commonly use a variety of dietary supplements, although evidence of their efficacy is often lacking. One such commonly used food supplement is Zyflamend, a polyherbal preparation with potent anti-inflammatory activities and preclinical efficacy against prostate and oral cancer.

Author(s): 
Kunnumakkara, Ajaikumar B.
Sung, Bokyung
Ravindran, Jayaraj
Diagaradjane, Parmeswaran
Deorukhkar, Amit
Dey, Sanjit
Koca, Cemile
Tong, Zhimin
Gelovani, Juri G.
Guha, Sushovan
Krishnan, Sunil
Aggarwal, Bharat B.
Publication Title: 
JOP: Journal of the pancreas

One of the greatest challenges in the treatment of pancreatic cancer remains its inherent lack of beneficial response to cytotoxic chemotherapy. According to the encyclopedic knowledge on herbal medicine regimen and clinical experience accumulated for centuries, traditional Chinese medicine can provide new avenues for alternative treatments of pancreatic diseases. Chinese herbal extracts have been widely used for the treatment of various cancers, but objective information on their efficacy in pancreatic cancer is lacking.

Author(s): 
Saif, Muhammad Wasif

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