Dermatologic Agents

Publication Title: 
Journal of the European Academy of Dermatology and Venereology: JEADV

Seborrheic dermatitis (SD) is normally treated with topical corticosteroids and antifungals. Oral therapies can be prescribed in severe or unresponsive cases. This review aims to assess the quantity and quality of published reports on oral therapies for SD. MEDLINE and Embase databases and the reference listings of publications were searched for any publication using oral treatment for SD. The quality of the included publications was assessed using a modified 27 item checklist by Downs and Black.

Author(s): 
Gupta, A. K.
Richardson, M.
Paquet, M.
Publication Title: 
BMJ clinical evidence

INTRODUCTION: Psoriasis affects 1-3% of the population, in some people causing changes to the nails and joints in addition to skin lesions. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of systemic drug treatments, topical drug treatments, and non-drug treatments (other than ultraviolet light) for chronic plaque psoriasis? What are the effects of ultraviolet light treatments for chronic plaque psoriasis?

Author(s): 
Naldi, Luigi
Rzany, Berthold
Publication Title: 
BMJ clinical evidence

INTRODUCTION: Psoriasis affects 1-3% of the population, in some people causing changes to the nails and joints in addition to skin lesions. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of systemic drug treatments, topical drug treatments, and non-drug treatments (other than ultraviolet light) for chronic plaque psoriasis? What are the effects of ultraviolet light treatments for chronic plaque psoriasis?

Author(s): 
Naldi, Luigi
Rzany, Berthold
Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: Chinese herbal medicine (CHM) has been increasingly used for atopic eczema. A previous version of this Cochrane review published in 2004 found some evidence of a possible benefit for oral ingestion of CHM for eczema, but the results were inconclusive and the evidence needs to be updated. We have expanded the scope of this review to include an assessment of the topical and oral effects of CHM for eczema. OBJECTIVES: To assess the effects of oral ingestion and topical applications of CHM for the management of eczema in children and adults.

Author(s): 
Gu, Sherman
Yang, Angela W. H.
Xue, Charlie C. L.
Li, Chun G.
Pang, Carmen
Zhang, Weiya
Williams, Hywel C.
Publication Title: 
Pharmaceutical Biology

CONTEXT: The galls of Terminalia chebula Retz. (Combretaceae) frequently appear in many Thai Lanna medicinal plant recipes for promotion of longevity. OBJECTIVE: The objective of this study was to evaluate the skin anti-aging of gel containing niosomes loaded with a semi-purified fraction containing gallic acid from T. chebula galls. METHOD: The semi-purified fraction containing phenolic compounds including gallic acid isolated from T.

Author(s): 
Manosroi, Aranya
Jantrawut, Pensak
Akihisa, Toshihiro
Manosroi, Worapaka
Manosroi, Jiradej
Publication Title: 
Forschende Komplementarmedizin (2006)

BACKGROUND: This study aimed to formulate a water-in-oil emulsion (formulation) of Terminalia chebula versus its vehicle (base) as control, and investigate its effects on skin melanin, skin erythema, skin moisture content, and transepidermal water loss (TEWL). MATERIAL AND METHODS: Base containing no active material, and formulation containing 5% concentrated extract of T. chebula, were developed. Different stability parameters were monitored at 8, 25, and 40 °C, as well as 40 °C + 75% relative humidity, for a period of 4 weeks.

Author(s): 
Akhtar, Naveed
Khan, Ali B.
Muhammad, Said
Ahmed, Mahmood
Khan, Haji M. Shoaib
Rasool, Fatima
Saeed, Tariq
Publication Title: 
American Family Physician

Atopic dermatitis, also known as atopic eczema, is a chronic pruritic skin condition affecting approximately 17.8 million persons in the United States. It can lead to significant morbidity. A simplified version of the U.K. Working Party's Diagnostic Criteria can help make the diagnosis. Asking about the presence and frequency of symptoms can allow physicians to grade the severity of the disease and response to treatment. Management consists of relieving symptoms and lengthening time between flare-ups. Regular, liberal use of emollients is recommended.

Author(s): 
Berke, Rebecca
Singh, Arshdeep
Guralnick, Mark
Publication Title: 
Journal of Ethnopharmacology

Oral and externally used dermatological preparation for acne vulgaris employing herbal extracts have been developed and standardized, the herbal extracts used here were of the plants described in ayurvedic treatise like Bhavprakasha Nighantu and Charak Samhita. The efficacy of the treatment using the oral formulation with or without external preparation has been assessed through conduct of Phase II clinical trials in 53 patients for 4 weeks in a randomized, double-blind, placebo-controlled fashion and following Good Clinical Practices guidelines.

Author(s): 
Lalla, J. K.
Nandedkar, S. Y.
Paranjape, M. H.
Talreja, N. B.
Publication Title: 
Pharmaceutical Biology

CONTEXT: Centella asiatica (L.) Urban (Apiaceae), a valuable herb described in Ayurveda, is used in the indigenous system of medicine as a tonic to treat skin diseases. OBJECTIVE: Centella asiatica methanol extract and its ethyl acetate, n-butanol and aqueous fraction, were subjected for the evaluation of skin care potential through the in vitro hyaluronidase, elastase and matrix metalloproteinase-1 (MMP-1) inhibitory assay. MATERIALS AND METHODS: The C. asiatica plant was extracted with methanol and fractionated with ethyl acetate, n-butanol and water.

Author(s): 
Nema, Neelesh Kumar
Maity, Niladri
Sarkar, Birendra Kumar
Mukherjee, Pulok Kumar
Publication Title: 
Journal of drugs in dermatology: JDD

Cellulite, a skin surface change that is nearly ubiquitous in women, is a condition that remains elusive to treatment. In fact, no treatment is completely successful as none are more than mildly and temporarily effective. Despite the lack of evidence to support efficacy, treatment options continue to proliferate.

Author(s): 
Wanner, Molly
Avram, Mathew

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