Desensitization, Immunologic

Publication Title: 
Health Technology Assessment (Winchester, England)

BACKGROUND: Atopic eczema is the commonest inflammatory skin disease of childhood, affecting 15-20% of children in the UK at any one time. Adults make up about one-third of all community cases. Moderate-to-severe atopic eczema can have a profound effect on the quality of life for both sufferers and their families.

Author(s): 
Hoare, C.
Li Wan Po, A.
Williams, H.
Publication Title: 
Clinical and Experimental Dermatology

This review provides a summary of key findings from 22 systematic reviews on atopic eczema (AE) published over the 2-year period from January 2012 to 31 December 2013, focusing on prevention and treatment of AE. For an update of systematic reviews on the epidemiology, mechanisms of disease and methodological issues, see Part 1 of this update. Based on current systematic review evidence, the most promising intervention for the prevention of AE is the use of probiotics (and possibly prebiotics) during the late stages of pregnancy and early life.

Author(s): 
Madhok, V.
Futamura, M.
Thomas, K. S.
Barbarot, S.
Publication Title: 
Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology

Allergy is an exaggerated response of the immune system to external substances. It plays a role in a wide range of diseases. In some, such as summer hayfever, the symptoms are due entirely to allergy. In other conditions, particularly asthma, eczema and urticaria, allergy plays a part in some patients but not all. In these situations, allergy may have either a major role or provide just one of many triggers. In an individual patient's illness, the importance of allergy may change with time.

Author(s): 
Kay, A. B.
Lessof, M. H.
Publication Title: 
Health Technology Assessment (Winchester, England)

BACKGROUND: Atopic eczema is the commonest inflammatory skin disease of childhood, affecting 15-20% of children in the UK at any one time. Adults make up about one-third of all community cases. Moderate-to-severe atopic eczema can have a profound effect on the quality of life for both sufferers and their families.

Author(s): 
Hoare, C.
Li Wan Po, A.
Williams, H.
Publication Title: 
Revue Médicale Suisse
Author(s): 
Schlegel-Christen, Simone
Publication Title: 
The Journal of Allergy and Clinical Immunology

BACKGROUND: There are no treatments currently available for peanut allergy. Sublingual immunotherapy (SLIT) is a novel approach to the treatment of peanut allergy. OBJECTIVE: We sought to investigate the safety, clinical effectiveness, and immunologic changes with SLIT in children with peanut allergy. METHODS: In this double-blind, placebo-controlled study subjects underwent 6 months of dose escalation and 6 months of maintenance dosing followed by a double-blind, placebo-controlled food challenge.

Author(s): 
Kim, Edwin H.
Bird, J. Andrew
Kulis, Michael
Laubach, Susan
Pons, Laurent
Shreffler, Wayne
Steele, Pamela
Kamilaris, Janet
Vickery, Brian
Burks, A. Wesley
Publication Title: 
Health Technology Assessment (Winchester, England)

BACKGROUND: Atopic eczema is the commonest inflammatory skin disease of childhood, affecting 15-20% of children in the UK at any one time. Adults make up about one-third of all community cases. Moderate-to-severe atopic eczema can have a profound effect on the quality of life for both sufferers and their families.

Author(s): 
Hoare, C.
Li Wan Po, A.
Williams, H.
Publication Title: 
Health Technology Assessment (Winchester, England)

BACKGROUND: Atopic eczema is the commonest inflammatory skin disease of childhood, affecting 15-20% of children in the UK at any one time. Adults make up about one-third of all community cases. Moderate-to-severe atopic eczema can have a profound effect on the quality of life for both sufferers and their families.

Author(s): 
Hoare, C.
Li Wan Po, A.
Williams, H.
Publication Title: 
The Annals of Pharmacotherapy

BACKGROUND: Studies using homeopathy have reported beneficial effects from treating allergy-related conditions. OBJECTIVE: To investigate the effects of a homeopathic drug prepared from common allergens (tree, grass, weed species) specific to the Southwest region of the US. METHODS: A 4-week, double-blind clinical trial comparing homeopathic preparations with placebo was conducted in the Phoenix metropolitan area during the regional allergy season from February to May.

Author(s): 
Kim, Linda S.
Riedlinger, June E.
Baldwin, Carol M.
Hilli, Lisa
Khalsa, Sarv Varta
Messer, Stephen A.
Waters, Robert F.
Publication Title: 
Current Opinion in Allergy and Clinical Immunology

PURPOSE OF REVIEW: The focus of this review will be on recent animal models of food allergy. Animal models are being used to investigate underlying mechanisms of IgE-mediated disease and for prophylactic/intervention therapies to treat allergic disease. RECENT FINDINGS: Considerable advances have been made in the dosage and use of sensitization routes with and without adjuvant and determinations of the pathophysiology of food allergy in murine, dog and swine food allergy models.

Author(s): 
Helm, Ricki M.
Burks, A. Wesley

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