Dextran Sulfate

Publication Title: 
American Journal of Physiology. Gastrointestinal and Liver Physiology

Extracts from Boswellia serrata have been reported to have anti-inflammatory activity, primarily via boswellic acid-mediated inhibition of leukotriene synthesis. In three small clinical trials, boswellia was shown to improve symptoms of ulcerative colitis and Crohn's disease, and because of its alleged safety, boswellia was considered superior over mesalazine in terms of a benefit-risk evaluation. The goal of this study was to evaluate the effectiveness of boswellia extracts in controlled settings of dextran sulfate- or trinitrobenzene sulfonic acid-induced colitis in mice.

Author(s): 
Kiela, Pawel R.
Midura, Anna J.
Kuscuoglu, Nesrin
Jolad, Shivanand D.
Sólyom, Aniko M.
Besselsen, David G.
Timmermann, Barbara N.
Ghishan, Fayez K.
Publication Title: 
Translational Research: The Journal of Laboratory and Clinical Medicine

Oxidant-mediated injury plays an important role in the pathophysiology of inflammatory bowel disease (IBD). Recently, antioxidants were shown to modulate colitis in mice. In this study, the protective effects of L-cysteine and glutathione (GSH) prodrugs are further evaluated against progression of colitis in a murine model. ICR mice were fed compounds incorporated into chow as follows: Group (A) received chow supplemented with vehicle. Group (B) was provided 2-(RS)-n-propylthiazolidine-4(R)-carboxylic-acid (PTCA), a cysteine prodrug.

Author(s): 
Oz, Helieh S.
Chen, Theresa S.
Nagasawa, Herbert
Publication Title: 
Carcinogenesis

Ulcerative colitis (UC) is a dynamic, idiopathic, chronic inflammatory condition associated with a high colon cancer risk. American ginseng has antioxidant properties and targets many of the players in inflammation. The aim of this study was to test whether American ginseng extract prevents and treats colitis. Colitis in mice was induced by the presence of 1% dextran sulfate sodium (DSS) in the drinking water or by 1% oxazolone rectally.

Author(s): 
Jin, Yu
Kotakadi, Venkata S.
Ying, Lei
Hofseth, Anne B.
Cui, Xiangli
Wood, Patricia A.
Windust, Anthony
Matesic, Lydia E.
Pena, Edsel A.
Chiuzan, Codruta
Singh, Narendra P.
Nagarkatti, Mitzi
Nagarkatti, Prakash S.
Wargovich, Michael J.
Hofseth, Lorne J.
Publication Title: 
Digestive Diseases and Sciences

The multifunctional pattern recognition scavenger receptors, SR-A and CD36, are predominantly expressed by lamina propria macrophages and considered important in innate immunity. We examined the role of these receptors in the pathophysiology of inflammatory bowel disease. Colitis was induced in wild type (WT), SRA(-/-), CD36(-/-), and SR-A/CD36 double deficient mice by administering DSS. DSS-induced moderately severe colitis in WT mice was manifested by weight loss, reduced hematocrit, and pathology.

Author(s): 
Oz, Helieh S.
Zhong, Jian
de Villiers, Willem J. S.
Publication Title: 
BMC immunology

BACKGROUND: Consumption of edible mushrooms has been suggested to improve health. A number of isolated mushroom constituents have been shown to modulate immunity. Five commonly consumed edible mushrooms were tested to determine whether whole mushrooms stimulate the immune system in vitro and in vivo. RESULTS: The white button (WB) extracts readily stimulated macrophage production of TNF-alpha. The crimini, maitake, oyster and shiitake extracts also stimulated TNF-alpha production in macrophage but the levels were lower than from WB stimulation.

Author(s): 
Yu, Sanhong
Weaver, Veronika
Martin, Keith
Cantorna, Margherita T.
Publication Title: 
Experimental Biology and Medicine (Maywood, N.J.)

Susceptibility to inflammatory bowel diseases depends upon interactions between the genetics of the individual and induction of chronic mucosal inflammation. We hypothesized that administration of dietary phenolics, caffeic acid and rutin, would suppress upregulation of inflammatory markers and intestinal damage in a mouse model of colitis. Colitis was induced in C3H/ HeOuJ mice (8 weeks old, 6 male/6 female per treatment) with 1.25% dextran sulfate sodium (DSS) for 6 d in their drinking water.

Author(s): 
Ye, Zhong
Liu, Zhiping
Henderson, Abigail
Lee, Kwangwon
Hostetter, Jesse
Wannemuehler, Michael
Hendrich, Suzanne
Publication Title: 
Journal of Periodontal Research

BACKGROUND AND OBJECTIVE: Chronic inflammatory bowel disease (IBD) demonstrates some similarities to the dysregulated chronic immunoinflammatory lesion of periodontitis. Trinitrobenzene sulphonic acid (TNBS) and dextran sodium sulphate (DSS) administered to rodents have been shown to elicit inflammatory responses that undermine the integrity of the gut epithelium in a similar manner to IBD in humans. The objective of this study was to evaluate the ability of these chemicals to elicit periodontal inflammation as a novel model for alveolar bone loss.

Author(s): 
Oz, H. S.
Ebersole, J. L.
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

Inflammatory bowel disease is a chronic, relapsing, and tissue-destructive disease. Resveratrol (3,4,5-trihydroxy-trans-stilbene), a naturally occurring polyphenol that exhibits beneficial pleiotropic health effects, is recognized as one of the most promising natural molecules in the prevention and treatment of chronic inflammatory disease and autoimmune disorders.

Author(s): 
Singh, Udai P.
Singh, Narendra P.
Singh, Balwan
Hofseth, Lorne J.
Price, Robert L.
Nagarkatti, Mitzi
Nagarkatti, Prakash S.
Publication Title: 
Cancer Prevention Research (Philadelphia, Pa.)

Ulcerative colitis is a dynamic, chronic inflammatory condition associated with an increased colon cancer risk. Inflammatory cell apoptosis is a key mechanism regulating ulcerative colitis. American ginseng (AG) is a putative antioxidant that can suppress hyperactive immune cells. We have recently shown that AG can prevent and treat mouse colitis. Because p53 levels are elevated in inflammatory cells in both mouse and human colitis, we tested the hypothesis that AG protects from colitis by driving inflammatory cell apoptosis through a p53 mechanism.

Author(s): 
Jin, Yu
Hofseth, Anne B.
Cui, Xiangli
Windust, Anthony J.
Poudyal, Deepak
Chumanevich, Alex A.
Matesic, Lydia E.
Singh, Narendra P.
Nagarkatti, Mitzi
Nagarkatti, Prakash S.
Hofseth, Lorne J.
Publication Title: 
BMC gastroenterology

BACKGROUND: Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor whose activation has been shown to modulate macrophage and T cell-mediated inflammation. The objective of this study was to investigate the mechanisms by which the deletion of PPAR gamma in T cells modulates immune cell distribution and colonic gene expression and the severity of experimental IBD. METHODS: PPAR gamma flfl; CD4 Cre+ (CD4cre) or Cre- (WT) mice were challenged with 2.5% dextran sodium sulfate in their drinking water for 0, 2, or 7 days.

Author(s): 
Guri, Amir J.
Mohapatra, Saroj K.
Horne, William T.
Hontecillas, Raquel
Bassaganya-Riera, Josep

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