Diabetes Mellitus

Publication Title: 
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie

Embelia ribes (ER) has been documented in Ayurveda for treating various diseases, including diabetes mellitus (DM). The present systematic review and meta-analysis evaluated the efficacy and safety of ER and its active bio-marker, embelin and its derivatives in the treatment of DM. Literature search was performed in PubMed/MEDLINE, EMBASE, Scopus, ScienceDirect, Scifinder, and Google Scholar.

Author(s): 
Durg, Sharanbasappa
Veerapur, Veeresh P.
Neelima, Satrasala
Dhadde, Shivsharan B.
Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: Patients with diabetes frequently use complimentary and alternative medications including Ayurvedic medications and hence it is important to determine their efficacy and safety. OBJECTIVES: To assess the effects of Ayurvedic treatments for diabetes mellitus.

Author(s): 
Sridharan, Kalpana
Mohan, Roshni
Ramaratnam, Sridharan
Panneerselvam, Deepak
Publication Title: 
The Journal of Family Practice

OBJECTIVE: To evaluate and synthesize the evidence on the effect of Ayurvedic therapies for diabetes mellitus. DESIGN: Systematic review of trials. MEASUREMENTS AND MAIN RESULTS: We found no study that assessed Ayurvedic as a system of care. Botanical therapy was by far the most commonly studied Ayurvedic treatment. Herbs were studied either singly or as formulas. In all, 993 titles in Western computerized databases and 318 titles identified by hand-searching journals in India were examined, yielding 54 articles reporting the results of 62 studies.

Author(s): 
Shekelle, Paul G.
Hardy, Mary
Morton, Sally C.
Coulter, Ian
Venuturupalli, Swamy
Favreau, Joya
Hilton, Lara K.
Publication Title: 
Indian journal of clinical biochemistry: IJCB

Water extract of dry fruits ofTerminalia chebula (Hindi-Harda, Telugu-Karakkaya) at a dose of 200 mg/kg body weight improved the glucose tolerance as indicated by 44% of reduction in the peak blood glucose at 2(nd) hour in glucose tolerance test in diabetic (streptozotocin induced) rats. Treatment of diabetic rats with an initial fasting blood glucose of 253±9.4 mg/dl daily once with the water extract (200 mg/kg) for two weeks brought down the fasting blood glucose to 123±8.4 mg/dl which is only slightly above the normal value.

Author(s): 
Murali, Y. K.
Chandra, Ramesh
Murthy, P. S.
Publication Title: 
African journal of traditional, complementary, and alternative medicines: AJTCAM

Diabetes mellitus is an endocrinological disorder arising from insulin deficiency or due to ineffectiveness of the insulin produced by the body. This results in high blood glucose and with time, to neurological, cardiovascular, retinal and renal complications. It is a debilitating disease and affects the population of every country of the world. Around 200 million people of the world suffer from this disease and this figure is projected to rise to 300 million in the coming years.

Author(s): 
Rahmatullah, Mohammed
Azam, Md Nur Kabidul
Khatun, Zubaida
Seraj, Syeda
Islam, Farhana
Rahman, Md Atiqur
Jahan, Sharmin
Aziz, Md Shah
Publication Title: 
Journal of Ethnobiology and Ethnomedicine

BACKGROUND: The usage of medicinal plants is traditionally rooted in Bangladesh and still an essential part of public healthcare. Recently, a dramatically increasing prevalence brought diabetes mellitus and its therapy to the focus of public health interests in Bangladesh. We conducted an ethnobotanical survey to identify the traditional medicinal plants being used to treat diabetes in Bangladesh and to critically assess their anti-diabetic potentials with focus on evidence-based criteria.

Author(s): 
Ocvirk, Soeren
Kistler, Martin
Khan, Shusmita
Talukder, Shamim Hayder
Hauner, Hans
Publication Title: 
Current Opinion in Drug Discovery & Development

TOR (target of rapamycin) is a serine-threonine protein kinase that is conserved across a diverse range of species from fungi to mammals. The signaling pathway that is anchored by TOR is also conserved across species. In mammals, mTOR integrates growth factor, amino acid, nutrient and energy sensing signals, and thus plays a major role in cell growth and proliferation, protein synthesis and autophagy.

Author(s): 
Sudarsanam, Sucha
Johnson, Dale E.
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

BACKGROUND: A significant component of the ability to survive to exceptional old age may be familial. This study assessed the prevalence of age-related diseases in the offspring of centenarians. METHODS: The health histories of centenarian offspring (n=177) and controls (n=166) were assessed from 1997-2000 using a cross-sectional study design. The offspring of 192 centenarian subjects enrolled in the nationwide New England Centenarian Study were recruited and enrolled.

Author(s): 
Terry, Dellara F.
Wilcox, Marsha
McCormick, Maegan A.
Lawler, Elizabeth
Perls, Thomas T.
Publication Title: 
Experimental Gerontology

Several studies have shown that centenarians have better cardiovascular risk profiles compared to younger old people. Some reports have revealed that cardiovascular diseases (i.e. hypertension, diabetes, angina and/or myocardial infarction) are less common in centenarians respect to 70 and 80 years old persons.

Author(s): 
Galioto, Antonio
Dominguez, Ligia J.
Pineo, Antonella
Ferlisi, Anna
Putignano, Ernesto
Belvedere, Mario
Costanza, Giuseppe
Barbagallo, Mario
Publication Title: 
Metabolism: Clinical and Experimental

OBJECTIVE: Glycated hemoglobin (HbA1c) is a stable index of chronic glycemic status and hyperglycemia associated with progressive development of insulin resistance and frank diabetes. It is also associated with premature aging and increased mortality. To uncover novel loci for HbA1c that are associated with healthy aging, we conducted a genome-wide association study (GWAS) using non-diabetic participants in the Long Life Family Study (LLFS), a study with familial clustering of exceptional longevity in the US and Denmark.

Author(s): 
An, Ping
Miljkovic, Iva
Thyagarajan, Bharat
Kraja, Aldi T.
Daw, E. Warwick
Pankow, James S.
Selvin, Elizabeth
Kao, W. H. Linda
Maruthur, Nisa M.
Nalls, Micahel A.
Liu, Yongmei
Harris, Tamara B.
Lee, Joseph H.
Borecki, Ingrid B.
Christensen, Kaare
Eckfeldt, John H.
Mayeux, Richard
Perls, Thomas T.
Newman, Anne B.
Province, Michael A.

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