Diabetes Mellitus, Experimental

Publication Title: 
Journal of Ethnopharmacology

Methanolic extract (75%) of Terminalia chebula, Terminalia belerica, Emblica officinalis and their combination named 'Triphala' (equal proportion of above three plant extracts) are being used extensively in Indian system of medicine. They were found to inhibit lipid peroxide formation and to scavenge hydroxyl and superoxide radicals in vitro. The concentration of plant extracts that inhibited 50% of lipid peroxidation induced with Fe(2+)/ascorbate were food to be 85.5, 27, 74 and 69 micro g/ml, respectively.

Author(s): 
Sabu, M. C.
Kuttan, Ramadasan
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Terminalia chebula (Combretaceae) has been widely used in Ayurveda for the treatment of diabetes. In the present investigation, the chloroform extract of T. chebula seed powder was investigated for its antidiabetic activity in streptozotocin-induced diabetic rats using short term and long term study protocols. The efficacy of the extract was also evaluated for protection of renal functions in diabetic rats.

Author(s): 
Rao, Nalamolu Koteswara
Nammi, Srinivas
Publication Title: 
Experimental and Clinical Endocrinology & Diabetes: Official Journal, German Society of Endocrinology [and] German Diabetes Association

The aqueous extract of the fruits of Terminalia chebula Retz. has been evaluated for its antidiabetic activity in streptozotocin (STZ) induced mild diabetic rats and compared with a known drug, tolbutamide. The oral effective dose (ED) of the extract was observed to be 200 mg/kg body weight, which produced a fall of 55.6% (p<0.01) in the oral glucose tolerance test.

Author(s): 
Murali, Y. K.
Anand, P.
Tandon, V.
Singh, R.
Chandra, R.
Murthy, P. S.
Publication Title: 
Biological & Pharmaceutical Bulletin

Terminalia chebula has been widely used in India as a folk medicine. This study investigated the in vivo anti-hyperglycemia and anti-diabetic complication effects of the EtOAc-soluble portion of ethanolic extract of T. chebula fruit (EETC) containing 29.4% chebulic acid. Rats were divided into non-diabetic, untreated diabetic and diabetic groups. Streptozotocin (40 mg/kg body weight (BW))-induced diabetic rats were orally administered the aminoguanidine (100 mg/kg BW), high dose (500 mg/kg BW; HEETC) and low dose (100 mg/kg BW; LEETC) for 13 weeks.

Author(s): 
Kim, Ji-hoon
Hong, Chung-Oui
Koo, Yun-chang
Kim, Su-Jung
Lee, Kwang-Won
Publication Title: 
Pharmaceutical Biology

CONTEXT: Diabetic nephropathy is one of the important microvascular complications of diabetes; however, the main problem remains is the control of progression of nephropathy in diabetes. Chebulic acid was selected, as tannins from Terminalia chebula are used as antidiabetic, renoprotective, antioxidant, hypotensive and an ?-glucosidase inhibitor. OBJECTIVE: In this study, we evaluated the effect of chebulic acid on ischemia reperfusion induced biochemical alteration in diabetic rats. MATERIALS AND METHODS: Chebulic acid (CA) was isolated from T.

Author(s): 
Silawat, Narendra
Gupta, Vipin Bihari
Publication Title: 
Diabetologia

AIMS/HYPOTHESIS: Sirtuin 1 (SIRT1) is a longevity-associated protein, which regulates energy metabolism and lifespan in response to nutrient deprivation. It has been proposed to be a therapeutic target for obesity and metabolic syndrome. We investigated whether ?-lipoic acid (ALA) exerts a lipid-lowering effect through regulation of SIRT1 activation and production in C(2)C(12) myotubes.

Author(s): 
Chen, W.-L.
Kang, C.-H.
Wang, S.-G.
Lee, H.-M.
Publication Title: 
Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica

The present study deals with the hypnotic effect of pentobarbital (Pento) in relation to its metabolism in hepatic microsomes in streptozotocin (STZ, 170 mg/kg, i.p.) injected mice. Liver weight (mg/10 g body wt.) of STZ-treated mice was larger than that of the controls throughout the experimental period. Although the shortening of sleeping time induced by Pento (60 mg/kg, i.p.) was always observed, Pento-metabolizing enzyme activity (by the method of Kato et al., 1964) increased in mice with diabetes for 2 and 4 weeks but decreased in mice with diabetes for 8 weeks.

Author(s): 
Fujii, E.
Tsukahara, F.
Nomoto, T.
Publication Title: 
Asia Pacific Journal of Clinical Nutrition

The antioxidant effect of an aqueous extract of Phaseolus vulgaris pods, an indigenous plant used in Ayurvedic medicine in India, was studied in rats with streptozotocin-induced diabetes. Oral administration of Phaseolus vulgaris pod extract (PPEt; 200 mg/kg body weight) for 45 days resulted in a significant reduction in thiobarbituric acid reactive substances and hydroperoxides.

Author(s): 
Venkateswaran, Subramanian
Pari, Leelavinothan
Publication Title: 
International Journal of Experimental Diabetes Research

Diabetes mellitus has been treated orally with herbal remedies based on folk medicine since ancient times. Embelia ribes burm (Myrsinaceae), known commonly as vidanga, was used in Ayurveda for its anthelmintic activity. Ayurveda describes vidanga as pungent, causes increase in digestive fire, and cures flatulence and colic. A single study reported the antihyperglycemic activity of decoction of E. ribes in glucose-induced hyperglycemic albino rabbits. In the present study, the lipid-lowering and antioxidant potential of ethanolic extract of E.

Author(s): 
Bhandari, Uma
Kanojia, Raman
Pillai, K. K.
Publication Title: 
Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]

Changes in the structural and functional properties of collagen caused by advanced glycation might be of importance for the etiology of late complications in diabetes. The present study was undertaken to investigate the influence of oral administration of aqueous pod extract (200 mg/kg body weight) of Phaseolus vulgaris, an indigenous plant used in Ayurvedic Medicine in India, on collagen content and characteristics in the tail tendon of streptozotocin-diabetic rats.

Author(s): 
Pari, L.
Venkateswaran, S.

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