Diabetic Nephropathies

Publication Title: 
PM & R: the journal of injury, function, and rehabilitation

OBJECTIVE: To develop a scientifically sound and clinically relevant evidence-based guideline for the treatment of painful diabetic neuropathy (PDN). METHODS: We performed a systematic review of the literature from 1960 to August 2008 and classified the studies according to the American Academy of Neurology classification of evidence scheme for a therapeutic article, and recommendations were linked to the strength of the evidence.

Author(s): 
Bril, Vera
England, John
Franklin, Gary M.
Backonja, Miroslav
Cohen, Jeffrey
Del Toro, David
Feldman, Eva
Iverson, Donald J.
Perkins, Bruce
Russell, James W.
Zochodne, Douglas
American Academy of Neurology
American Association of Neuromuscular and Electrodiagnostic Medicine
American Academy of Physical Medicine and Rehabilitation
Publication Title: 
Pharmaceutical Biology

CONTEXT: Diabetic nephropathy is one of the important microvascular complications of diabetes; however, the main problem remains is the control of progression of nephropathy in diabetes. Chebulic acid was selected, as tannins from Terminalia chebula are used as antidiabetic, renoprotective, antioxidant, hypotensive and an ?-glucosidase inhibitor. OBJECTIVE: In this study, we evaluated the effect of chebulic acid on ischemia reperfusion induced biochemical alteration in diabetic rats. MATERIALS AND METHODS: Chebulic acid (CA) was isolated from T.

Author(s): 
Silawat, Narendra
Gupta, Vipin Bihari
Publication Title: 
Archives of Pharmacal Research

Caloric restriction prolongs the lifespan of many species. Therefore, investigators have researched the usefulness of caloric restriction for healthy lifespan extension. Sirt1, an NAD(+)-dependent deacetylase, was identified as a molecule necessary for caloric restriction-related anti-aging strategies. Sirt1 functions as an intracellular energy sensor to detect the concentration of NAD(+), and controls in vivo metabolic changes under caloric restriction and starvation through its deacetylase activity to many targets including histones, nuclear transcriptional factors, and enzymes.

Author(s): 
Kume, Shinji
Kitada, Munehiro
Kanasaki, Keizo
Maegawa, Hiroshi
Koya, Daisuke
Publication Title: 
Clinical Science (London, England: 1979)

Sirtuins are members of the Sir2 (silent information regulator 2) family, a group of class III deacetylases. Mammals have seven different sirtuins, SIRT1-SIRT7. Among them, SIRT1, SIRT3 and SIRT6 are induced by calorie restriction conditions and are considered anti-aging molecules. SIRT1 has been the most extensively studied. SIRT1 deacetylates target proteins using the coenzyme NAD+ and is therefore linked to cellular energy metabolism and the redox state through multiple signalling and survival pathways.

Author(s): 
Kitada, Munehiro
Kume, Shinji
Takeda-Watanabe, Ai
Kanasaki, Keizo
Koya, Daisuke
Publication Title: 
Comprehensive Therapy

It appears inevitable that with increased longevity, the management of the elderly diabetic will place even greater demands on hospital services. It seems reasonable to adopt a more liberal attitude to the regulation of control of diabetes in the elderly than in younger patients. However, the view that diabetes in the elderly is always mild can be dangerously misleading. A significant number of elderly diabetics develop ketoacidosis or other serious forms of metabolic disturbance, and in these patients the mortality is high.

Author(s): 
Walsh, C. H.
Publication Title: 
Clinical Science (London, England: 1979)

Sirtuins are members of the Sir2 (silent information regulator 2) family, a group of class III deacetylases. Mammals have seven different sirtuins, SIRT1-SIRT7. Among them, SIRT1, SIRT3 and SIRT6 are induced by calorie restriction conditions and are considered anti-aging molecules. SIRT1 has been the most extensively studied. SIRT1 deacetylates target proteins using the coenzyme NAD+ and is therefore linked to cellular energy metabolism and the redox state through multiple signalling and survival pathways.

Author(s): 
Kitada, Munehiro
Kume, Shinji
Takeda-Watanabe, Ai
Kanasaki, Keizo
Koya, Daisuke
Publication Title: 
Nephrology, Dialysis, Transplantation: Official Publication of the European Dialysis and Transplant Association - European Renal Association

BACKGROUND: Inflammation is commonly associated with malnutrition and cardiovascular disease in end-stage renal failure patients. Anti-inflammatory properties of the isoflavones, a micronutrient component of soy, have been reported in several experimental models and disease conditions, but never in renal failure. We hypothesized that dietary soy isoflavones correct laboratory evidence of systemic inflammation in haemodialysis (HD) patients with underlying high blood levels of C-reactive protein (CRP).

Author(s): 
Fanti, Paolo
Asmis, Reto
Stephenson, Tammy J.
Sawaya, B. Peter
Franke, Adrian A.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Curcumin has anti-inflammatory, anti-oxidant, and anti-proliferative properties, and depending upon the experimental circumstances, may be pro- or anti-apoptotic. Many of these biological actions could ameliorate diabetic nephropathy. METHODS/DESIGN: Mouse podocytes, cultured in basal or high glucose conditions, underwent acute exposure to curcumin. Western blots for p38-MAPK, COX-2 and cleaved caspase-3; isoelectric focusing for HSP25 phosphorylation; and DNase I assays for F- to G- actin cleavage were performed for in vitro analyses.

Author(s): 
Ma, Jun
Phillips, Lynetta
Wang, Ying
Dai, Tiane
LaPage, Janine
Natarajan, Rama
Adler, Sharon G.
Publication Title: 
International Journal of Molecular Medicine

We previously reported that PMI-5011, an ethanolic extract of Artemisia dracunculus L., alleviates peripheral neuropathy in high fat diet-fed mice, a model of prediabetes and obesity developing oxidative stress and pro-inflammatory changes in the peripheral nervous system. This study evaluated PMI-5011 on established functional, structural, and biochemical changes associated with Type I diabetic peripheral neuropathy.

Author(s): 
Watcho, Pierre
Stavniichuk, Roman
Tane, Pierre
Shevalye, Hanna
Maksimchyk, Yury
Pacher, Pal
Obrosova, Irina G.
Publication Title: 
Arteriosclerosis, Thrombosis, and Vascular Biology

OBJECTIVE: Type 1 diabetes (T1DM) is a proinflammatory state and confers an increased risk for vascular complications. Toll-like receptors (TLR) could participate in diabetic vasculopathies. Whether TLR activation contributes to the proinflammatory state of T1DM and the pathogenesis of diabetic nephropathy remains unknown. METHODS AND RESULTS: We induced T1DM in TLR2 knockout mice (TLR2-/-) and wild-type littermates (C57BL/6J-WT) using streptozotocin (STZ).

Author(s): 
Devaraj, Sridevi
Tobias, Peter
Kasinath, Balakuntalam S.
Ramsamooj, Rajendra
Afify, Alaa
Jialal, Ishwarlal

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