Diabetic Neuropathies

Publication Title: 
The Journal of Clinical Endocrinology and Metabolism

CONTEXT: Up to 25% of individuals with diabetes develop painful diabetic neuropathy, suffering spontaneous pain, allodynia, hyperalgesia, and other unpleasant symptoms. Decreased physical activity, increased fatigue, and mood and sleep problems may result. EVIDENCE ACQUISITION: A MEDLINE search was conducted, limiting searching to double-blind, randomized, controlled trials (1978 to present) of antiepileptic drugs (carbamazepine, gabapentin, pregabalin, topiramate, and lamotrigine) used in the treatment of chronic neuropathic pain.

Author(s): 
Vinik, Aaron
Publication Title: 
The Journal of Clinical Endocrinology and Metabolism

CONTEXT: Up to 25% of individuals with diabetes develop painful diabetic neuropathy, suffering spontaneous pain, allodynia, hyperalgesia, and other unpleasant symptoms. Decreased physical activity, increased fatigue, and mood and sleep problems may result. EVIDENCE ACQUISITION: A MEDLINE search was conducted, limiting searching to double-blind, randomized, controlled trials (1978 to present) of antiepileptic drugs (carbamazepine, gabapentin, pregabalin, topiramate, and lamotrigine) used in the treatment of chronic neuropathic pain.

Author(s): 
Vinik, Aaron
Publication Title: 
PloS One

OBJECTIVE: Manual acupuncture has commonly been used in China, either alone or in combination with conventional medicine, to treat diabetic peripheral neuropathy (DPN). The objective of this study was to perform a systematic review to evaluate the potential benefits and harms of manual acupuncture for DPN to justify its clinical use. METHODS: We searched for published and unpublished randomized controlled trials of manual acupuncture for DPN till 31 March 2013.

Author(s): 
Chen, Wei
Yang, Guo-Yan
Liu, Bo
Manheimer, Eric
Liu, Jian-Ping
Publication Title: 
PloS One

[This corrects the article DOI: 10.1371/journal.pone.0073764.].

Author(s): 
PLOS ONE Staff
Publication Title: 
Muscle & Nerve

The objective of this report was to develop a scientifically sound and clinically relevant evidence-based guideline for the treatment of painful diabetic neuropathy (PDN).

Author(s): 
Bril, Vera
England, John D.
Franklin, Gary M.
Backonja, Miroslav
Cohen, Jeffrey A.
Del Toro, David R.
Feldman, Eva L.
Iverson, Donald J.
Perkins, Bruce
Russell, James W.
Zochodne, Douglas W.
American Academy of Neurology
American Asociation of Neuromuscular and Electrodiagnostic Medicine
American Academy of Physical Medicine and Rehabilitation
Publication Title: 
Neurology

OBJECTIVE: To develop a scientifically sound and clinically relevant evidence-based guideline for the treatment of painful diabetic neuropathy (PDN). METHODS: We performed a systematic review of the literature from 1960 to August 2008 and classified the studies according to the American Academy of Neurology classification of evidence scheme for a therapeutic article, and recommendations were linked to the strength of the evidence.

Author(s): 
Bril, V.
England, J.
Franklin, G. M.
Backonja, M.
Cohen, J.
Del Toro, D.
Feldman, E.
Iverson, D. J.
Perkins, B.
Russell, J. W.
Zochodne, D.
American Academy of Neurology
American Association of Neuromuscular and Electrodiagnostic Medicine
American Academy of Physical Medicine and Rehabilitation
Publication Title: 
Comprehensive Therapy

It appears inevitable that with increased longevity, the management of the elderly diabetic will place even greater demands on hospital services. It seems reasonable to adopt a more liberal attitude to the regulation of control of diabetes in the elderly than in younger patients. However, the view that diabetes in the elderly is always mild can be dangerously misleading. A significant number of elderly diabetics develop ketoacidosis or other serious forms of metabolic disturbance, and in these patients the mortality is high.

Author(s): 
Walsh, C. H.
Publication Title: 
Zeitschrift F¸r Die Gesamte Innere Medizin Und Ihre Grenzgebiete

In the diabetes population of the GDR by means of the dispensary network of the consulting points 159 diabetics with a duration of the disease of at least 40 years were recognized and investigated on the basis of a standardized documentation material. 23 diabetics had survived their disease for longer than 50 years. The number of benign long-term courses in males was absolutely and relatively higher.

Author(s): 
Panzram, G.
Pissarek, D.
Michaelis, D.
Schliack, V.
Publication Title: 
Journal of Pain & Palliative Care Pharmacotherapy

This feature presents information for patients in a question and answer format. It is written to simulate actual questions that many pain patients ask and to provide answers in a context and language that most pain patients will comprehend. Issues addressed in this issue are carpel tunnel syndrome, fibromyalgia, glucosamine and chondroitin, hypnosis, marijuana.

Author(s): 
Fishman, Scott M.
Publication Title: 
Phytotherapy research: PTR

The efficacy of Momordica charantia (MC), Eugenia jambolana (EJ), Tinospora cordifolia (TC) and Mucuna pruriens (MP) was assessed in the prevention of murine alloxan dibetic cataract. Alloxan (120 mg/kg) was used as the diabetogenic agent. While controls and diabetic controls did not receive any plant extract, treated rats received lyophilized aqueous extract of MC and EJ (200 mg/kg p.o.), alcohol extract of TC (400 mg/kg) and MP (200 mg/kg p.o.) every day until 4 months. Serum glucose concentration was assessed and cataracts examined with both the naked eye and through a slit lamp.

Author(s): 
Rathi, S. S.
Grover, J. K.
Vikrant, Vats
Biswas, N. R.

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