Dinoprost

Publication Title: 
The Journal of Nutrition, Health & Aging

Decreasing oxidative stress and increasing antioxidant defense has been hypothesized as one mechanism by which caloric restriction (CR) increases longevity in animals. A total of 46 moderately overweight volunteers (BMI: 25-30 kg/m2), ages 20-42 yr were randomized to either high glycemic (HG) or low glycemic (LG) dietary load CR regimen at either 10% (n=12) or 30% (n=34) of basal caloric intake. All food was provided to participants for 6 mo.

Author(s): 
Meydani, M.
Das, S.
Band, M.
Epstein, S.
Roberts, S.
Publication Title: 
Psychoneuroendocrinology

Chronic psychological stress appears to accelerate biological aging, and oxidative damage is an important potential mediator of this process. However, the mechanisms by which psychological stress promotes oxidative damage are poorly understood. This study investigates the theory that cortisol increases in response to an acutely stressful event have the potential to either enhance or undermine psychobiological resilience to oxidative damage, depending on the body's prior exposure to chronic psychological stress.

Author(s): 
Aschbacher, Kirstin
O'Donovan, Aoife
Wolkowitz, Owen M.
Dhabhar, Firdaus S.
Su, Yali
Epel, Elissa
Publication Title: 
Pediatric endocrinology reviews: PER

Painful menstruation is a cyclic painful condition that adversely affects the woman's wellbeing for a large part of her life. Its pathogenesis is not always understood. Prostaglandins seem to be intimately involved in primary dysmenorrhoea although it is difficult to understand the underlying cause for their excessive secretion. Abnormalities in plasma steroid levels could account for the disturbance, especially significantly elevated plasma levels of estradiol in the luteal phase.

Author(s): 
Tzafettas, John
Publication Title: 
BMC pulmonary medicine

BACKGROUND: There is a substantial body of evidence on the efficacy of yoga in the management of bronchial asthma. Many studies have reported, as the effects of yoga on bronchial asthma, significant improvements in pulmonary functions, quality of life and reduction in airway hyper-reactivity, frequency of attacks and medication use. In addition, a few studies have attempted to understand the effects of yoga on exercise-induced bronchoconstriction (EIB) or exercise tolerance capacity.

Author(s): 
Vempati, Ramaprabhu
Bijlani, Ramesh Lal
Deepak, Kishore Kumar
Publication Title: 
Cancer Research

Apurinic/apyrimidinic endonuclease is a key enzyme in the process of base excision repair, required for the repair of spontaneous base damage that arises as a result of oxidative damage to DNA. In mice, this endonuclease is coded by the Apex gene, disruption of which is incompatible with embryonic life. Here we confirm the embryonic lethality of Apex-null mice and report the phenotypic characterization of mice that are heterozygous mutants for the Apex gene (Apex+/-). We show that Apex heterozygous mutant cells and animals are abnormally sensitive to increased oxidative stress.

Author(s): 
Meira, L. B.
Devaraj, S.
Kisby, G. E.
Burns, D. K.
Daniel, R. L.
Hammer, R. E.
Grundy, S.
Jialal, I.
Friedberg, E. C.
Publication Title: 
Clinical Chemistry

BACKGROUND: Oxidative stress is pivotal in atherogenesis. Although the most widely used indirect assay to quantify oxidative stress is LDL oxidative susceptibility, direct assays such as urinary F(2)-isoprostanes have shown great promise. METHODS: We evaluated the utility of both a direct measure of oxidative stress (urinary F(2)-isoprostanes) and an indirect measure of copper-catalyzed, LDL oxidation in a model of increased oxidative stress (diabetes). We also evaluated an enzyme immunoassay (EIA) method for urinary F(2)-isoprostanes with a gas chromatography-mass spectrometry method.

Author(s): 
Devaraj, S.
Hirany, S. V.
Burk, R. F.
Jialal, I.
Publication Title: 
The Journal of Nutritional Biochemistry

Nonsteroidal anti-inflammatory drugs such as aspirin are used for pain relief and chemoprevention against cancer, but frequently cause gastric mucosal injury. We examined whether combinations of aspirin and alpha-tocopherol (alphaT) or aspirin and gamma-tocopherol (gammaT), with alphaT and gammaT being the two major forms of vitamin E, are better anti-inflammatory agents than aspirin alone, and whether these combinations alleviate aspirin-associated side effects.

Author(s): 
Jiang, Qing
Moreland, Michelle
Ames, Bruce N.
Yin, Xinmin
Publication Title: 
Journal of Lipid Research

Western diets are enriched in omega-6 vs. omega-3 fatty acids, and a shift in this balance toward omega-3 fatty acids may have health benefits. There is limited information about the catabolism of 3-series prostaglandins (PG) formed from eicosapentaenoic acid (EPA), a fish oil omega-3 fatty acid that becomes elevated in tissues following fish oil consumption. Quantification of appropriate urinary 3-series PG metabolites could be used for noninvasive measurement of omega-3 fatty acid tone.

Author(s): 
Kuklev, Dmitry V.
Hankin, Joseph A.
Uhlson, Charis L.
Hong, Yu H.
Murphy, Robert C.
Smith, William L.
Publication Title: 
Drug Metabolism and Disposition: The Biological Fate of Chemicals

Milk thistle (Silybum marianum) extracts, one of the most widely used dietary supplements, contain a mixture of six major flavonolignans (silybin A, silybin B, isosilybin A, isosilybin B, silychristin, and silydianin) and other components. However, the pharmacokinetics of the free individual flavonolignans have been only partially investigated in humans. Furthermore, antioxidant effects of the extract, which may underlie the basis of many therapeutic effects, have not been thoroughly assessed.

Author(s): 
Zhu, Hao-Jie
Brinda, Bryan J.
Chavin, Kenneth D.
Bernstein, Hilary J.
Patrick, Kennerly S.
Markowitz, John S.
Publication Title: 
BMC pulmonary medicine

BACKGROUND: There is a substantial body of evidence on the efficacy of yoga in the management of bronchial asthma. Many studies have reported, as the effects of yoga on bronchial asthma, significant improvements in pulmonary functions, quality of life and reduction in airway hyper-reactivity, frequency of attacks and medication use. In addition, a few studies have attempted to understand the effects of yoga on exercise-induced bronchoconstriction (EIB) or exercise tolerance capacity.

Author(s): 
Vempati, Ramaprabhu
Bijlani, Ramesh Lal
Deepak, Kishore Kumar

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