Directly Observed Therapy

Publication Title: 
African Health Sciences

The current global tuberculosis (TB) epidemic has pressured health care managers, particularly in developing countries, to seek for alternative, innovative ways of delivering effective treatment to the large number of TB patients diagnosed annually. One strategy employed is direct observation of treatment (DOT) for all patients. In high-burden settings innovation with this strategy has resulted into the use of lay community members to supervise TB patients during the duration of anti-TB treatment. However, community involvement in health programmes is not a simple matter.

Kironde, Samson
Bajunirwe, Francis
Publication Title: 
Malaria Journal

BACKGROUND: A six-dose antimalarial regimen of artemether-lumefantrine (A/L) may soon become one of the most widely used drug combination in Africa, despite possible constraints with adherence and poor absorption due to inadequate nutrition, and a lack of pharmacokinetic and effectiveness data. METHODS: Within a trial of supervised versus unsupervised A/L treatment in a stable Ugandan Plasmodium falciparum transmission setting, plasma lumefantrine concentrations were measured in a subset of patients on day 3 (C [lum]day3) and day 7 (C [lum]day7) post-inclusion.

Checchi, Francesco
Piola, Patrice
Fogg, Carole
Bajunirwe, Francis
Biraro, Samuel
Grandesso, Francesco
Ruzagira, Eugene
Babigumira, Joseph
Kigozi, Isaac
Kiguli, James
Kyomuhendo, Juliet
Ferradini, Laurent
Taylor, Walter R. J.
Guthmann, Jean-Paul
Publication Title: 
Emerging Infectious Diseases

Resistance to many antimalaria drugs developed on the Cambodia-Thailand border long before developing elsewhere. Because antimalaria resistance is now a global problem, artemisinin-based combination therapies (ACTs) are the first-line therapies in most malaria-endemic countries. However, recent clinical and molecular studies suggest the emergence of ACT-resistant Plasmodium falciparum infections in the Cambodia-Thailand border area, where standard ACT is artesunate and mefloquine.

Wongsrichanalai, Chansuda
Meshnick, Steven R.
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