Disease Susceptibility

Publication Title: 
Experimental Gerontology

The aim of the present study was to investigate the association between blood groups and life expectancy. We compared frequencies of ABO blood group in 269 centenarians (persons over 100 years) living in Tokyo and those in regionally matched controls (n=7153). Frequencies of blood types A, O, B, and AB in centenarians were 34.2, 28.3, 29.4, and 8.2%, respectively, while those in controls were 38.6, 30.1, 21.9, and 9.4%, respectively. Blood type B was observed more frequently in centenarians than in controls (chi(2)=8.41, P=0.04).

Author(s): 
Shimizu, Kenichiro
Hirose, Nobuyoshi
Ebihara, Yoshinori
Arai, Yasumichi
Hamamatsu, Michiyo
Nakazawa, Susumu
Masui, Yukie
Inagaki, Hiroki
Gondo, Yasuyuki
Fujimori, Junko
Kanno, Yoshiko
Konishi, Kanoko
Kitagawa, Koji
Publication Title: 
Mechanisms of Ageing and Development

Our previous work revealed that 88% of centenarians delay or escape the age-related lethal diseases cardiac disease, stroke and diabetes. In the cases of those having a history of cancer we have observed anecdotes of centenarians presenting with large primary tumors that would have otherwise been expected to have metastasized and to have been lethal. However, these tumors were removed without consequence.

Author(s): 
Andersen, Stacy L.
Terry, Dellara F.
Wilcox, Marsha A.
Babineau, Timothy
Malek, Karim
Perls, Thomas T.
Publication Title: 
MÈdecine Sciences: M/S

Aging is a complex process that is accompanied by the onset of a series of age-related diseases, including Alzheimer's disease. Aging is controlled by a combination of genetic and environmental factors. Among the genes that regulate aging, the insulin-FOXO signaling pathway plays a central role, as this pathway regulates lifespan in multiple species, such as worms, flies, and mice. In humans, exceptional longevity - being a centenarian - is also associated with genetic variation in this insulin-FOXO pathway.

Author(s): 
Brunet, Anne
Publication Title: 
MÈdecine Sciences: M/S

Aging is a complex process that is accompanied by the onset of a series of age-related diseases, including Alzheimer's disease. Aging is controlled by a combination of genetic and environmental factors. Among the genes that regulate aging, the insulin-FOXO signaling pathway plays a central role, as this pathway regulates lifespan in multiple species, such as worms, flies, and mice. In humans, exceptional longevity - being a centenarian - is also associated with genetic variation in this insulin-FOXO pathway.

Author(s): 
Brunet, Anne
Publication Title: 
British Medical Bulletin

Non-insulin-dependent diabetes mellitus (NIDDM) occurs predominantly after the age of 50 years but is not easy to distinguish from late onset insulin-dependent diabetes. It is likely that misclassification is rare in a Caucasian population. Whilst NIDDM is widely believed to be genetically determined, recent epidemiological observations have consistently revealed statistical associations between indices of poor fetal and infant growth with susceptibility to loss of glucose tolerance in adult life.

Author(s): 
Hales, C. N.
Publication Title: 
Journal of the American Dietetic Association
Author(s): 
McCaffree, Jim
Publication Title: 
NestlÈ Nutrition Workshop Series. Paediatric Programme

Effects of in utero and early life conditions on adult health and disease such as cardiovascular disease and type 2 diabetes are well documented by epidemiological and clinical observations. Animal models including intrauterine artery ligation, maternal restriction of iron, protein or general caloric intake, provide invaluable tools to understand mechanisms linking early growth and later diseases in adult life. In addition, the rodent model of maternal protein restriction has revealed that longevity can be influenced either positively or negatively by early growth patterns.

Author(s): 
Chen, J.-H.
Cottrell, E. C.
Ozanne, S. E.
Publication Title: 
MÈdecine Sciences: M/S

In half a century, the number of nonagenarians and/or centenarians has dramatically increased, particularly due to the increase in life expectancy at old age. However, successful aging is more important than longevity. All along their life, people can act to preserve their health, their physical and mental abilities as well as their autonomy. This requires a healthy diet, having physical and intellectual appropriate activities and a right use of medical care. Finally, maintaining a social role and a raison d'Ítre in old age are also major factors in successful aging.

Author(s): 
Berr, Claudine
Balard, FrÈdÈric
Blain, Hubert
Robine, Jean-Marie
Publication Title: 
MÈdecine Sciences: M/S

Aging is a complex process that is accompanied by the onset of a series of age-related diseases, including Alzheimer's disease. Aging is controlled by a combination of genetic and environmental factors. Among the genes that regulate aging, the insulin-FOXO signaling pathway plays a central role, as this pathway regulates lifespan in multiple species, such as worms, flies, and mice. In humans, exceptional longevity - being a centenarian - is also associated with genetic variation in this insulin-FOXO pathway.

Author(s): 
Brunet, Anne
Publication Title: 
Aging Cell

Rapamycin has been shown to extend lifespan in numerous model organisms including mice, with the most dramatic longevity effects reported in females. However, little is known about the functional ramifications of this longevity-enhancing paradigm in mammalian tissues. We treated 24-month-old female C57BL/6J mice with rapamycin for 3†months and determined health outcomes via a variety of noninvasive measures of cardiovascular, skeletal, and metabolic health for individual mice.

Author(s): 
Flynn, James M.
O'Leary, Monique N.
Zambataro, Christopher A.
Academia, Emmeline C.
Presley, Michael P.
Garrett, Brittany J.
Zykovich, Artem
Mooney, Sean D.
Strong, Randy
Rosen, Clifford J.
Kapahi, Pankaj
Nelson, Michael D.
Kennedy, Brian K.
Melov, Simon

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