DNA Tumor Viruses

Publication Title: 
Experimental Cell Research

Lymphocytes have a finite and predictable proliferative life span in culture similar to that observed in fibroblasts. In general, the senescence of human fibroblasts is inevitable and irreversible, but their proliferative life span can be extended by certain DNA tumor virus oncogenes, such as the large T antigen of the SV40 virus. Here, we show that human T lymphocytes (HTL) can be stably transfected with SV40 large T and that expression of T antigen extended the life span of T cell cultures.

Author(s): 
Ryan, Q. C.
Goonewardene, I. M.
Murasko, D. M.
Subscribe to RSS - DNA Tumor Viruses