DNMT1

Publication Title: 
Journal of Genetics and Genomics = Yi Chuan Xue Bao

The most remarkable feature of the nervous system is that the development and functions of the brain are largely reshaped by postnatal experiences, in joint with genetic landscapes. The nature vs. nurture argument reminds us that both genetic and epigenetic information is indispensable for the normal function of the brain. The epigenetic regulatory mechanisms in the central nervous system have been revealed over last a decade. Moreover, the mutations of epigenetic modulator genes have been shown to be implicated in neuropsychiatric disorders, such as autism spectrum disorders.

Author(s): 
Lv, Jingwen
Xin, Yongjuan
Zhou, Wenhao
Qiu, Zilong
Publication Title: 
Progress in Neuro-Psychopharmacology & Biological Psychiatry

Glutamate decarboxylases (GAD67/65; GAD1/GAD2) are crucially involved in gamma-aminobutyric acid (GABA) synthesis and thus were repeatedly suggested to play an important role in the pathogenesis of anxiety disorders. In the present study, DNA methylation patterns in the GAD1 and GAD2 promoter and GAD1 intron 2 regions were investigated for association with panic disorder, with particular attention to possible effects of environmental factors.

Author(s): 
Domschke, Katharina
Tidow, Nicola
Schrempf, Marie
Schwarte, Kathrin
Klauke, Benedikt
Reif, Andreas
Kersting, Anette
Arolt, Volker
Zwanzger, Peter
Deckert, J¸rgen
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