Dopamine and cAMP-Regulated Phosphoprotein 32

Publication Title: 
Physiological Genomics

Caloric restriction (CR) is an effective method for prevention of age-associated diseases as well as overweight and obesity; however, there is controversy regarding the effects of dieting regimens on behavior. In this study, we investigated two different dieting regimens: repeated fasting and refeeding (RFR) and daily feeding of half the amount of food consumed by RFR mice (CR). CR and RFR mice had an approximate 20% reduction in food intake compared with control mice.

Author(s): 
Yamamoto, Yuta
Tanahashi, Toshihito
Kawai, Tomoko
Chikahisa, Sachiko
Katsuura, Sakurako
Nishida, Kensei
Teshima-Kondo, Shigetada
Sei, Hiroyoshi
Rokutan, Kazuhito
Publication Title: 
The Journal of Biological Chemistry

The bis-indole indirubin is an active ingredient of Danggui Longhui Wan, a traditional Chinese medicine recipe used in the treatment of chronic diseases such as leukemias. The antitumoral properties of indirubin appear to correlate with their antimitotic effects. Indirubins were recently described as potent (IC(50): 50-100 nm) inhibitors of cyclin-dependent kinases (CDKs). We report here that indirubins are also powerful inhibitors (IC(50): 5-50 nm) of an evolutionarily related kinase, glycogen synthase kinase-3beta (GSK-3 beta).

Author(s): 
Leclerc, S.
Garnier, M.
Hoessel, R.
Marko, D.
Bibb, J. A.
Snyder, G. L.
Greengard, P.
Biernat, J.
Wu, Y. Z.
Mandelkow, E. M.
Eisenbrand, G.
Meijer, L.
Publication Title: 
PloS One

Parkinson's disease (PD) is caused by the selective loss of dopaminergic neurons in the substantia nigra (SN) and the depletion of striatal dopamine (DA). Acupuncture, as an alternative therapy for PD, has beneficial effects in both PD patients and PD animal models, although the underlying mechanisms therein remain uncertain. The present study investigated whether acupuncture treatment affected dopamine neurotransmission in a PD mouse model using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

Author(s): 
Kim, Seung-Nam
Doo, Ah-Reum
Park, Ji-Yeun
Bae, Hyungjin
Chae, Younbyoung
Shim, Insop
Lee, Hyangsook
Moon, Woongjoon
Lee, Hyejung
Park, Hi-Joon
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