Dose-Response Relationship, Drug

Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Helicobacter pylori infection is associated with gastritis, peptic ulcer, and gastric cancer. Due to its high global prevalence and uprising resistance to available antibiotics, efforts are now directed to identify alternative source to treat and prevent associated disorders.

Author(s): 
Zaidi, Syed Faisal
Muhammad, Jibran Sualeh
Shahryar, Saeeda
Usmanghani, Khan
Gilani, Anwarul-Hassan
Jafri, Wasim
Sugiyama, Toshiro
Publication Title: 
Journal of Enzyme Inhibition and Medicinal Chemistry

Terminalia chebula fruit extracts were prepared sequentially with hexane, ethyl acetate, methanol and methanol-water (70:30) and tested for their ?-glucosidase inhibitory and antioxidant potential. The study resulted in the formulation of an extract with high ?-glucosidase inhibitory potential (IC(50) 0.19 ± 0.03 µg mL(-1)) enriched with hydrolysable tannins.

Author(s): 
Sasidharan, Indu
Sundaresan, A.
Nisha, V. M.
Kirishna, Mahesh S.
Raghu, K. G.
Jayamurthy, P.
Publication Title: 
International Braz J Urol: Official Journal of the Brazilian Society of Urology

PURPOSE: Kidney stone is one of the most prevalent diseases worldwide. Calcium oxalate (CaOx) has been shown to be the main component of the majority of stones formed in the urinary system of the patients with urolithiasis. The present study evaluates the antilithiatic properties of Terminalia chebula commonly called as ?harad ? which is often used in ayurveda to treat various urinary diseases including kidney stones. MATERIALS AND METHODS: The antilithiatic activity of Terminalia chebula was investigated on nucleation and growth of the calcium oxalate crystals.

Author(s): 
Tayal, S.
Duggal, S.
Bandyopadhyay, P.
Aggarwal, A.
Tandon, S.
Tandon, C.
Publication Title: 
Pharmaceutical Biology

CONTEXT: Diabetic nephropathy is one of the important microvascular complications of diabetes; however, the main problem remains is the control of progression of nephropathy in diabetes. Chebulic acid was selected, as tannins from Terminalia chebula are used as antidiabetic, renoprotective, antioxidant, hypotensive and an ?-glucosidase inhibitor. OBJECTIVE: In this study, we evaluated the effect of chebulic acid on ischemia reperfusion induced biochemical alteration in diabetic rats. MATERIALS AND METHODS: Chebulic acid (CA) was isolated from T.

Author(s): 
Silawat, Narendra
Gupta, Vipin Bihari
Publication Title: 
Alternative Therapies in Health and Medicine

CONTEXT: In India, vaidyas (Ayurvedic physicians) traditionally administer triphala and its constituents as therapeutic agents for promoting digestion and satiety. OBJECTIVE: The research team performed the present study to investigate the effects of triphala and its constituents (T bellirica [bibhitaki], T chebula [haritaki], and E officinalis [amalaki]) on the dietary induction of obesity (diet-induced obesity [DIO]), and other symptoms of visceral obesity syndrome, in mice fed a high-fat diet (HFD).

Author(s): 
Gurjar, Shaifali
Pal, Anuradha
Kapur, Suman
Publication Title: 
Pharmaceutical Biology

CONTEXT: Arthritis is inflammation of one or more joints. Terminalia chebula Retz. (Combretaceae) fruit is mentioned in Ayurveda as useful in treating arthritic disorders. OBJECTIVE: This work was undertaken to evaluate the anti-inflammatory, antioxidant, anti-lipid peroxidative and membrane-stabilizing effects of hydroalcoholic extract of Terminalia chebula fruits and also to establish a possible association between them. MATERIALS AND METHODS: In vivo anti-inflammatory activity of T. chebula fruit extract at different doses ranged from 50 to 500?mg/kg, p.o.

Author(s): 
Bag, Anwesa
Kumar Bhattacharyya, Subir
Kumar Pal, Nishith
Ranjan Chattopadhyay, Rabi
Publication Title: 
Pharmaceutical Biology

Context Chebulae Fructus is used as an herbal remedy for diarrhoea in traditional Chinese medicine. However, there is no scientific evidence to support its antidiarrhoeal activity. Objective This study evaluates the antidiarrhoeal properties of Chebulae Fructus aqueous extract (CFAE) and determines the active fraction. Materials and methods The antidiarrhoeal effect of CFAE (200-800?mg/kg) was investigated by determining the wet dropping, intestinal transit in BALB/c mice and enteropooling in Wister rats.

Author(s): 
Sheng, Zunlai
Yan, Xin
Zhang, Ruili
Ni, Huilin
Cui, Yuanxu
Ge, Junwei
Shan, Anshan
Publication Title: 
Bioorganic & Medicinal Chemistry Letters

Three new polyhydroxytriterpenoid derivatives, 23-O-neochebuloylarjungenin 28-O-?-d-glycopyranosyl ester (1), 23-O-4'-epi-neochebuloylarjungenin (2), and 23-O-galloylpinfaenoic acid 28-O-?-d-glucopyranosyl ester (17) were isolated from the fruits of Terminalia chebula Retz. along with fourteen known ones. Their structures were elucidated by 1D and 2D NMR spectroscopic data and acid hydrolysis.

Author(s): 
Lee, Dong Young
Yang, Heejung
Kim, Hyun Woo
Sung, Sang Hyun
Publication Title: 
Ecotoxicology and Environmental Safety

Aedes aegypti Linn is one of the most important mosquito species. The vectors are responsible for causing deadly diseases like dengue and dengue hemorrhagic fever. Several chemical pesticides used to control these dengue vectors caused severe toxic significances on human health and other non-target beneficial insects. Therefore the current investigation has been made to access the bio-efficacy of the crude seed extracts of T. chebula against the dengue vector Ae. aegypti. The GC-MS analysis of crude seed extracts of T.

Author(s): 
Thanigaivel, Annamalai
Vasantha-Srinivasan, Prabhakaran
Senthil-Nathan, Sengottayan
Edwin, Edward-Sam
Ponsankar, Athirstam
Chellappandian, Muthiah
Selin-Rani, Selvaraj
Lija-Escaline, Jalasteen
Kalaivani, Kandaswamy
Publication Title: 
Journal of Neurochemistry

The search for effective treatments that prevent oxidative stress associated with premature ageing and neurodegenerative diseases is an important area of neurochemical research. As age- and disease-related oxidative stress is frequently associated with mitochondrial dysfunction, amphiphilic antioxidant agents of high stability and selectivity that target these organelles can provide on-site protection.

Author(s): 
Poeggeler, Burkhard
Durand, GrÈgory
Polidori, Ange
Pappolla, Miguel A.
Vega-Naredo, Ignacio
Coto-Montes, Ana
Bˆker, Jutta
Hardeland, R¸diger
Pucci, Bernard

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