Doxycycline

Publication Title: 
Arthritis and Rheumatism

OBJECTIVE: To evaluate the informed consent process for a clinical trial of intravenous doxycycline for rheumatoid arthritis. METHODS: Participants completed a self-administered questionnaire about the consent process at baseline and 16 weeks following enrollment in a clinical trial. RESULTS: Respondents (n = 30) affirmed voluntary participation in the parent trial. Participants acknowledged hope and altruism as reasons for entering the trial more than expectation of personal benefit or outside influences.

Author(s): 
Criscione, Lisa G.
Sugarman, Jeremy
Sanders, Linda
Pisetsky, David S.
St Clair, E. William
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

The in vitro activities of doxycycline, chloroquine, quinine, amodiaquine, artemether, pyrimethamine, and cycloguanil were evaluated against Plasmodium falciparum isolates from Senegal (Dielmo and Ndiop), using an isotopic, micro, drug susceptibility test. The 71-50% inhibitory concentration (IC50) values for doxycycline ranged from 0.7 to 108.0 microM and the geometric mean IC50 for the 71 isolates was 11.3 microM (95% confidence interval = 9.5-13.4 microM).

Author(s): 
Pradines, B.
Spiegel, A.
Rogier, C.
Tall, A.
Mosnier, J.
Fusai, T.
Trape, J. F.
Parzy, D.
Publication Title: 
British Journal of Clinical Pharmacology

AIMS: To describe the population pharmacokinetics of tafenoquine in healthy volunteers after receiving tafenoquine for malaria prophylaxis. METHODS: The population consisted of 135 male Thai soldiers (mean age 28.9 years; weight 60.3 kg). All soldiers were presumptively treated with artesunate for 3 days plus doxycycline for 7 days to remove any pre-existing malaria infections. After the treatment regime, 104 soldiers (drug group) received a loading dose of 400 mg tafenoquine base daily for 3 days followed by 400 mg tafenoquine monthly for 5 consecutive months.

Author(s): 
Edstein, M. D.
Kocisko, D. A.
Brewer, T. G.
Walsh, D. S.
Eamsila, C.
Charles, B. G.
Publication Title: 
Antimicrobial Agents and Chemotherapy

Parallel in vitro tests, assessing the inhibition of schizont maturation, were conducted with 31 fresh isolates of Plasmodium falciparum from Thailand, using artemisinin, doxycycline, and combinations of both. The activities of artemisinin and doxycycline are obviously not correlated. Both compounds showed consistent synergism at 50% effective concentration (EC(50)), EC(90), and EC(99) levels.

Author(s): 
Sponer, Ulrike
Prajakwong, Somsak
Wiedermann, Gerhard
Kollaritsch, Herwig
Wernsdorfer, Gunther
Wernsdorfer, Walther H.
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

Documentation on the efficacy of artesunate in Africa is limited, and no experience of artesunate use in Sudan is documented. Severe malaria in rural areas of Sudan, where facilities for the safe and effective use of parenteral quinine are lacking, is a frequent problem. Early treatment with artesunate suppositories would provide a simple method for use by unskilled staff and would be an alternative approach to treat malaria in settings with poor resources.

Author(s): 
Awad, M. I.
Alkadru, A. M. Y.
Behrens, R. H.
Baraka, O. Z.
Eltayeb, I. B.
Publication Title: 
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America

We measured plasma tafenoquine concentrations in Thai soldiers given a monthly regimen of tafenoquine to determine whether these concentrations adequately suppressed malarial infections on the Thai-Cambodian border. After receiving a treatment course of artesunate and doxycycline, 104 male soldiers were administered a loading dose of tafenoquine (400 mg daily for 3 days), followed by tafenoquine monthly (400 mg every 4 weeks) for 5 months.

Author(s): 
Edstein, Michael D.
Kocisko, David A.
Walsh, Douglas S.
Eamsila, Chirapa
Charles, Bruce G.
Rieckmann, Karl H.
Publication Title: 
Antimicrobial Agents and Chemotherapy

The pharmacokinetics of oral doxycycline administered at 200 mg every 24 h were investigated in 17 patients recovering from severe Plasmodium falciparum malaria. The data suggest that the doses of doxycycline currently recommended (circa 3.5 mg/kg of body weight daily) may not be optimal.

Author(s): 
Newton, Paul N.
Chaulet, Jean-François
Brockman, Alan
Chierakul, Wirongrong
Dondorp, Arjen
Ruangveerayuth, Ronatrai
Looareesuwan, Sornchai
Mounier, Cyril
White, Nicholas J.
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

This randomized, open-label study compared a three-day, six-dose regimen of artemether-lumefantrine with a five-day, 19-dose regimen of quinine-doxycycline for the treatment of Plasmodium falciparum malaria in the western Amazon region of Brazil. All patients remained hospitalized during their treatment and the study assessments were scheduled daily from the start of treatment (day 0) through day 6. By day 3, the percentage of infected patients was 0% in the artemether-lumefantrine group and 48.8% in the quinine-doxycycline group.

Author(s): 
Alecrim, Maria G.
Lacerda, Marcus V.
Mourão, Maria P.
Alecrim, Wilson D.
Padilha, Alexandre
Cardoso, Bernardo S.
Boulos, Marcos
Publication Title: 
Antimicrobial Agents and Chemotherapy

Doxycycline is reported to impair second-generation parasite schizogony. The effects of doxycycline alone and combined with dihydroartemisinin were investigated in a murine malaria model. Doxycycline lowered the rate of parasite growth within 2 days, with maximum effect in 6 days. Addition of dihydroartemisinin led to an additive antimalarial effect.

Author(s): 
Batty, Kevin T.
Law, Angela S. F.
Stirling, Verity
Moore, Brioni R.
Publication Title: 
Malaria Journal

Plasmodium falciparum infection is known to be associated with a spectrum of systemic complications ranging from mild and self-limiting to life-threatening. This case report illustrates a patient who had a protracted course in hospital due to several rare complications of falciparum malaria. A 21-year old man presented with a five-day history of high-grade fever, jaundice and abdominal pain and a two-day history of altered conscious state. A diagnosis of severe falciparum malaria was made based on the clinical presentation and a positive blood smear with parasitaemia of 45%.

Author(s): 
Seshadri, Pratibha
Dev, Anand Vimal
Viggeswarpu, Surekha
Sathyendra, Sowmya
Peter, John Victor

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