Droperidol

Publication Title: 
Acta Anaesthesiologica Belgica

A simplified, safe and flexible technique of anesthesia, based on a limited number of relatively cheap drugs, and allowing ventilation with air, was applied to 60 patients undergoing operations of at least 60 minutes' duration. The required depth of hypnosis was produced by intravenous diazepam or gamma-OH, whilst droperidol and fentanyl provided a satisfactory degree of sedation and analgesia. Pancuronium bromide was used for muscle relaxation. Spontaneous respiration was resumed immediately after postoperative use of nalorphine and neostigmine.

Author(s): 
Lelkens, J. P.
Publication Title: 
Anesthesia and Analgesia

An etomidate infusion regimen for hypnosis as part of balanced, totally intravenous anesthesia was designed to maintain plasma etomidate concentrations above the awakening concentration of 300 ng/ml while avoiding dose-related side effects. The etomidate infusion regimen of 0.1 mg/kg/min for 3 min, 0.02 mg/kg/min for 27 min, and 0.01 mg/kg/min for the remainder of the anesthesia was used together with intravenous bolus doses of fentanyl, droperidol, and pancuronium. This was evaluated in 11 patients and the kinetics of etomidate were reexamined.

Author(s): 
Fragen, R. J.
Avram, M. J.
Henthorn, T. K.
Caldwell, N. J.
Publication Title: 
Cahiers D'anesthésiologie

We studied the effect of DBP on thiopentone hypnosis in 580 patients aged 20 to 30 and 560 patients aged 40 to 50. The hypnotic effect of thiopentone was evaluated after 5, 15, 30, 45 and 60 minutes from intravenous administration of 0.05 mg.kg-1 of DBP by using dose-effect curves to identify the ED50 dose. The ED50 value of thiopentone decreased up to 15 minutes after DBP (about 1.1 mg.kg-1 in both age groups) and increased after 30, 45 and 60 minutes, the increase being higher in the patients aged 40 to 50.

Author(s): 
Manani, G.
Costa, G.
Civran, E.
Zanette, G.
Bortoluzzi, A.
Milan Manani, S.
Publication Title: 
European Journal of Anaesthesiology

We investigated the effect of a small dose of midazolam, ketamine, droperidol or lidocaine on the propofol dose required for hypnosis during induction of general anaesthesia. These drugs were randomly administered to 100 patients about to undergo scheduled surgery. Propofol was then infused at a rate of 250 microg kg-1 min-1 and the hypnotic dose to produce hypnosis was evaluated.

Author(s): 
Adachi, Y. U.
Uchihashi, Y.
Watanabe, K.
Satoh, T.
Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

AIM: To study the expression of preproenkephalin (PPE) mRNA following electroacupuncture (EA) combined with droperidol (Dro), an antagonist of dopamine receptors. METHOD: The brains of Sprague-Dawley rats were sectioned after combination of EA with Dro and nonradioactive in situ hybridization histochemistry (ISHH) technic was used.

Author(s): 
Zhu, C. B.
Li, X. Y.
Zhu, Y. H.
Xu, S. F.
Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

AIM: To study if mu receptor participates in the process of potentiation of droperidol (Dro) on acupuncture analgesia (AA). METHODS: Autoradiographic technic was used. Ohmefentanyl, a highly selective ligand of mu receptors, was used in radio-receptor binding assay in Sprague-Dawley rat brain sections. RESULTS: The binding sites of [beta-3H, p-benzoyl-3H]ohmefentanyl were increased greatly in many nuclei of rat brain after AA, and were further increased when AA was enhanced by Dro.

Author(s): 
Zhu, C. B.
Li, X. Y.
Zhu, Y. H.
Xu, S. F.
Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

AIM: To study the expression of preproopiomelanocortin (POMC) and preprodynorphin (PPD) mRNA following the combination of electroacupuncture (EA) with droperidol (Dro), a dopamine receptor antagonist. METHODS: The brains and spinal cords of Sprague-Dawley rats were sectioned after combination of EA with Dro, and the gene expression was investigated using nonradioactive in situ hybridization histochemistry (ISHH). RESULTS: Ten hours after EA, the POMC mRNA expression was enhanced; the expression was further enhanced when EA was combined with Dro.

Author(s): 
Zhu, C. B.
Li, X. Y.
Zhu, Y. H.
Xu, S. F.
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